Mechanistic Understanding of Differences in Cytotoxicity Induced by Food Additives Methyleugenol and Methylisoeugenol.

Methyleugenol (ME) has been classified as a "group 2B carcinogen" by IARC. Its positional isomer methylisoeugenol (MIE) has been considered to be of "generally recognized as safe'' status by FDA. ME was more cytotoxic than MIE in cultured mouse primary hepatocytes.

NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma.

Background: Nucleolar protein 7 (NOL7), a specific protein found in the nucleolus, is crucial for maintaining cell division and proliferation. While the involvement of NOL7 in influencing the unfavorable prognosis of metastatic melanoma has been reported, its significance in predicting the prognosis of patients with Hepatocellular Carcinoma (HCC) remains unclear.

Methods: Aberrant expression of NOL7 in HCC and its prognostic value were evaluated using multiple databases, including TCGA, GTEx, Xiantao Academic, HCCDB, UALCAN, TISCH, and STRING.

An effective cell-penetrating peptide-based loading method to extracellular vesicles and enhancement in cellular delivery of drugs.

Extracellular vesicles (EVs) have been demonstrated to own the advantages in evading phagocytosis, crossing biological barriers, and possessing excellent biocompatibility and intrinsic stability. Based on these characteristics, EVs have been used as effective therapeutic carriers for drug delivery, but the low drug loading capacity greatly limits further applications. Herein, we developed a drug loading method based on cell-penetrating peptide (CPP) to enhance the encapsulation of therapeutic reagents in EVs, and EVs-based drug delivery system achieved higher killing efficacy to tumor cells.

In Situ Conversion of Atherosclerotic Plaques' Iron into Nanotheranostics.

The presence of a substantial necrotic core in atherosclerotic plaques markedly heightens the risk of rupture, a consequence of elevated iron levels that exacerbate oxidative stress and lipid peroxidation, thereby sustaining a detrimental cycle of ferroptosis and inflammation. Concurrently targeting both ferroptosis and inflammation is crucial for the effective treatment of vulnerable plaques. In this study, we introduce gallium hexacyanoferrate nanoabsorption catalysts (GaHCF NACs) designed to disrupt this pathological cycle.

A Single Early Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.

Whether early life acetaminophen (APAP) exposures injure the developing lung is controversial. We sought to correlate murine pulmonary developmental expression profiles of to susceptibility to APAP exposure. P14 C57BL/6 mice were exposed to APAP (140 mg/kg x 1, IP) and assessed for evidence of a histologic, metabolic, functional, and/or transcriptional pulmonary response.

Molecular Characterization of Whole Genome Sequencing of spp. in Shapingba District, Chongqing, China, 2016-2023.

In recent years, infection is a major global public health concern, particularly in food safety. This study analyzed the genomes of 102 strains isolated between 2016 and 2023 from food, foodborne disease patients, and food poisoning incidents, focusing on their molecular characteristics, antibiotic resistance genes (ARGs), and virulence genes. serovar Enteritidis (37.

Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study.

Background: The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real-world settings.

Methods: Patients with moderate-to-severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow-up period of at least 16 weeks at 10 hospitals in China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, and dermatology life quality index for adults or children (DLQI/CDLQI) to assess disease control status and quality of life impairment, and monitored adverse events to assess the safety.

Relationship Between Intense Personal Celebrity Worship and Cosmetic Surgery Consideration Among Chinese Young Women: The Serial Mediating Effects of Body Dissatisfaction and Body Shame.

This study examined whether intense personal feelings toward celebrities are positively correlated with women's consideration of cosmetic surgery, and whether body dissatisfaction and body shame serve as possible mediators of this relationship. A sample of 605 Chinese female undergraduates completed questionnaires on celebrity worship, consideration of cosmetic surgery, body dissatisfaction, and body shame. The results revealed a significant positive correlation between intense personal feelings toward celebrities and the consideration of cosmetic surgery.

Comparative Analysis of CXCR5 Circulating DNA Methylation Levels in Autoimmune Rheumatic Diseases.

Objective: To assess CXC chemokine receptor 5 (CXCR5) circulating DNA methylation differences in autoimmune rheumatic diseases and their relation with clinical features.

Methods: Targeted methylation sequencing was performed using peripheral blood from 164 rheumatoid arthritis (RA), 30 systemic lupus erythematosus (SLE), 30 ankylosing spondylitis (AS), 30 psoriatic arthritis (PsA), 24 Sjögren's syndrome (SS) patients, and 30 healthy controls (HC).

Results: Significant differences in CXCR5 cg19599951 methylation were found between RA and HC, as well as AS and SLE.

The affective iconicity of lexical tone: Evidence from standard Chinesea).

Previous studies suggested that pitch characteristics of lexical tones in Standard Chinese influence various sensory perceptions, but whether they iconically bias emotional experience remained unclear. We analyzed the arousal and valence ratings of bi-syllabic words in two corpora (Study 1) and conducted an affect rating experiment using a carefully designed corpus of bi-syllabic words (Study 2). Two-alternative forced-choice tasks further tested the robustness of lexical tones' affective iconicity in an auditory nonce word context (Study 3).

RNASEK interacting with PEDV structural proteins facilitates virus entry via clathrin-mediated endocytosis.

Porcine epidemic diarrhea virus (PEDV), as a type of Alphacoronavirus causing acute diarrhea and high death rate among sucking piglets, poses great financial damage to the swine industry. Nevertheless, the molecular mechanism whereby PEDV enters host cells is unclear, limiting the development of PED vaccines and anti-PEDV agents. The present study found that the host protein ribonuclease kappa (RNASEK) was regulated by USF2, a transcription factor, and facilitated the PEDV replication.

The Association of Persistent Hyperuricemia With Liver Function and the Management of Uric Acid Levels: Insights From a Three-Year Prospective Cohort Study.

Objective: The association of long-term hyperuricemia with liver function remains less well understood. This prospective cohort study aimed to investigate the relationship between hyperuricemia and liver function as well as other metabolic and cardiovascular parameters.

Methods: We enrolled 375 participants with hyperuricemia and 599 normouricemic controls.

Single-cell RNA Sequencing Revealed the Immunophenotypic Features of Macrophages in Cardiac Transplants and Uncovered Lgals9 Promoted Their Polarization towards The M2b Subtype.

Macrophages play a crucial role in the immune response during allograft rejection in organ transplantation. Therefore, our study aimed to explore the genomic features of macrophages in mouse heart transplants and use single-cell RNA sequencing to investigate Galectin-9 (Gal-9, Lgals9), a lectin that can mediate the activation and differentiation of immune cells through ligand-receptor interactions, and the effects of its regulation in transplantation. We discovered a new subset of macrophages called "Myoz2+ macrophages", which specifically expressed genes related to myocardial contraction.

Extracellular Mitochondrial-Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction.

Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cytometry to detect EVs in DFU skin tissues is used and found a significant increase in the Translocase of Outer Mitochondrial Membrane 20 (TOM20) mitochondrial-derived vesicles (MDVs). The role of MDVs in DFU is yet to be reported.

Exceptional CO2 Hydrogenation to Ethanol via Precise Single-Atom Ir Deposition on Functional P Islands.

The thermocatalytic hydrogenation of CO2 to ethanol has attracted significant interest because ethanol offers ease of transport and substantial value in chemical synthesis. Here, we present a state-of-the-art catalyst for the CO2 hydrogenation to ethanol achieved by precisely depositing single-atom Ir species on P cluster islands situated on the In2O3 nanosheets. The Ir1-Px/In2O3 catalyst achieves an impressive ethanol yield of 3.

Cell proliferation suppressor RBR1 interacts with ARID1 to promote pollen mitosis via stabilizing DUO1 in Arabidopsis.

In plants, sperm cell formation involves two rounds of pollen mitoses, in which the microspore initiates the first pollen mitosis (PMI) to produce a vegetative cell and a generative cell, then the generative cell continues the second mitosis (PMII) to produce two sperm cells. DUO1, a R2R3 Myb transcription factor, is activated in the generative cell to promote S-G2/M transition during PMII. Loss-of-function of DUO1 caused a complete arrest of PMII.

Selective synthesis of triacylglycerols by the ADS-17-supported Candida antarctica lipase B through esterification of oleic acid and glycerol.

Background: Immobilized enzyme possessing both high activity and good selectivity is important in practice. In this study, Candida antarctica lipase B (CALB) was immobilized onto the macroporous resin ADS-17 for triacylglycerol (TAG) synthesis through esterification of oleic acid and glycerol. The reaction conditions were optimized by single-factor study and orthogonal test, and the reusability of the immobilized CALB (CALB@ADS-17) was evaluated.

Robust Diagnosis of Acute Bacterial and Viral Infections via Host Gene Expression Rank-Based Ensemble Machine Learning Algorithm: A Multi-Cohort Model Development and Validation Study.

Background: The accurate and prompt diagnosis of infections is essential for improving patient outcomes and preventing bacterial drug resistance. Host gene expression profiling as an approach to infection diagnosis holds great potential in assisting early and accurate diagnosis of infection.

Methods: To improve the precision of infection diagnosis, we developed InfectDiagno, a rank-based ensemble machine learning algorithm for infection diagnosis via host gene expression patterns.

Influence of hypertension diagnosis and subjective life expectancy on health behaviors among middle-aged and older Chinese adults.

Objectives: Hypertension can lead to significant health complications if left unmanaged due to unhealthy behaviors. This study investigates hypertension related health behaviors of middle-aged and older Chinese adults, investigating whether a hypertension diagnosis and individuals' subjective life expectancy (SLE) might prompt positive changes in their health behaviors.

Methods: The participants in this study were Chinese adults aged 45 years and older, selected from the 2013-2020 China Health and Retirement Longitudinal Study.

Trends in tuberculosis mortality among older adults in China, 2004-2021: a Joinpoint regression and age-period-cohort analysis.

Background: Tuberculosis (TB) remains a major public health problem in China and globally, particularly among older adults. This study aimed to examine secular trends in TB mortality among older adults in China and the net effects of age, period, and cohort.

Methods: Data from the National Disease Surveillance Points (DSPs) system were analyzed using Joinpoint regression to determine annual changes in TB mortality among individuals aged 60 years and older from 2004 to 2021.

Effects of upper extremity blood flow restriction training on muscle strength and hypertrophy: a systematic review and meta-analysis.

Background: Low load resistance training with blood flow restriction (LL-BFRT) has been shown to improve muscle strength and hypertrophic function. The effect of LL-BFRT on lower extremity muscle improvement has been widely discussed. However, no studies have discussed the effect of this training method on the upper extremity muscles until now.

What do we know: positive impact of hip-hop pedagogy on student's learning effects.

Over the last decade, hip-hop pedagogy has received a lot of attention in the field of education because of its significance in improving students' learning effects. This review articulates the current understanding of the positive impact of hip-hop pedagogy on students' learning effects within publications, an under-researched area. Based on a review of previous studies, this review innovatively examines six major elements of hip-hop pedagogy (DJ, MC, cypher, breakdance, knowledge, and graffiti) and concludes that the six major elements of hip-hop pedagogy can, in terms of the four dimensions of learning motivation, engagement, learning and memorization, and critical thinking, improve students' learning effects.

Corrigendum: The causal relationship between serum metabolites and the risk of psoriasis: a Mendelian randomization and meta-analysis study.

[This corrects the article DOI: 10.3389/fimmu.2024.

Relationship between maternal pre-pregnancy BMI and neonatal birth weight in pregnancies with gestational diabetes mellitus: a retrospective cohort study.

Aim: The aim of this study was to explore the association between maternal pre-pregnancy body mass index (BMI) and neonatal birth weight in pregnancies with gestational diabetes mellitus (GDM).

Methods: This was a retrospective cohort study conducted between January 2019 and June 2020 at a university hospital in Fuzhou, China.

Results: Pre-pregnancy BMI was used to categorize 791 pregnant women as underweight (3.

Exploration of ANKRD27 as an immune-related prognostic factor in pan-cancer and hepatocellular carcinoma.

Introduction: Ankyrin repeat domain 27 (ANKRD27) has been found to be associated with certain cancers. However, its clinical potential in pan-cancer remains unclear.

Methods: Public datasets (TCGA and GTEx) were applied to analyze ANKRD27 expression in multiple cancer types and its correlations with immune scores, immune checkpoint genes, and immune modulatory genes.