Publications by authors named "Qingsheng Liang"
Background: It is unclear whether patients with metabolic dysfunction-associated steatotic liver disease (MASLD) are allowed variable low levels of alcohol. This study aimed to evaluate the effect of mild-moderate alcohol consumption on the biochemical and histological characteristics of patients with MASLD.
Methods: Alcohol consumption was assessed in 713 patients with steatotic liver disease (SLD) who underwent liver biopsy.
Background And Aims: The use of corticosteroids in chronic drug-induced liver injury (DILI) is an important issue. Our previous randomized controlled trial showed that patients with chronic DILI benefited from a 48-week steroid stepwise reduction (SSR) regimen. However, it remains unclear whether a shorter course of therapy can achieve similar efficacy.
View Article and Find Full Text PDFBackground: The influence of chronic hepatitis B infection (CBI) on hepatic steatosis, necroinflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD) population was unclear. We aimed to investigate the effect of CBI on hepatic steatosis and assess the association between NAFLD co-existed CBI and hepatic injury in NAFLD pediatric population.
Methods: Consecutive hospitalized children with biopsy-proven NAFLD with or without CBI were included.
Article Synopsis
- The study focuses on understanding non-acetaminophen (APAP) drug-induced acute liver failure (ALF) by identifying risk factors and creating a predictive model for transplant-free survival (TFS).
- An analysis of 482 patients revealed that the most common cause of liver failure was herbal and dietary supplements, with a predominant hepatocellular injury pattern.
- The DIALF-5 model, developed from clinical factors, showed superior prediction for 21-day TFS compared to established models (MELD, KCC) and is validated for use in different patient cohorts, making it a practical tool for clinicians.
Article Synopsis
- The study aimed to create and validate a predictive model using alanine aminotransferase (ALT) and total bilirubin (TB) patterns to forecast acute liver failure (ALF) in patients with drug-induced liver injury (DILI).
- Patients were categorized based on their ALT and TB levels into different patterns, with findings indicating that those with a double-separate-peak (DSP) pattern had a significantly higher risk of developing ALF compared to other patterns.
- The predictive accuracy of the model improved when including additional liver function markers (INR and ALP), allowing for better identification of high-risk DILI patients and potentially leading to timely intervention for improved patient outcomes.
Background: Treatment of chronic drug-induced liver injury (DILI) or herb-induced liver injury(HILI) is an important and unresolved challenge. There is no consensus regarding the indications for corticosteroids for chronic DILI/HILI.
Aims: To investigate the efficacy and safety of corticosteroid plus glycyrrhizin for patients with chronic DILI/HILI.
Alcoholic liver disease (ALD) is a complication that is a burden on global health and economy. Interleukin-33 (IL-33) is a newly identified member of the IL-1 cytokine family and is released as an "alarmin" during inflammation. Soluble suppression of tumourigenicity 2 (sST2), an IL-33 decoy receptor, has been reported as a new biomarker for the severity of systemic and highly inflammatory diseases.
View Article and Find Full Text PDFHerbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened.
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