[Evidence mapping analysis of clinical studies in treatment of chronic kidney disease with traditional Chinese medicine in recent ten years].

Traditional Chinese medicine(TCM) has significant advantages in treatment of chronic kidney disease, but its clinical research evidence needs to be further summarized and improved. By means of evidence mapping, this paper systematically categorized the clinical research on TCM in treating chronic kidney disease in recent ten years, so as to understand the existing evidence level in this field and offer a reference for addressing current issues. The relevant literature published between January 1, 2013 and December 31, 2023 was systematically searched in both Chinese and English databases.

Epidemiological Characteristics of Varicella in Anhui Province, China, 2012-2021: Surveillance Study.

Background: Varicella is a mild, self-limited disease caused by varicella-zoster virus (VZV) infection. Recently, the disease burden of varicella has been gradually increasing in China; however, the epidemiological characteristics of varicella have not been reported for Anhui Province.

Objective: The aim of this study was to analyze the epidemiology of varicella in Anhui from 2012 to 2021, which can provide a basis for the future study and formulation of varicella prevention and control policies in the province.

Immunogenicity of Tetravalent Protein Vaccine SCTV01E-2 against SARS-CoV-2 EG.5 Subvaraint: A Phase 2 Trial.

The Omicron EG.5 lineage of SARS-CoV-2 is currently on a trajectory to become the dominant strain. This phase 2 study aims to evaluate the immunogenicity of SCTV01E-2, a tetravalent protein vaccine, with a specific emphasis on its immunogenicity against Omicron EG.

[Network Meta-analysis of efficacy of Chinese patent medicine in treatment of inflammatory response in diabetic nephropathy].

This study aimed to evaluate the efficacy and safety of various Chinese patent medicines in the treatment of inflammatory response in diabetic nephropathy(DN) based on network Meta-analysis. Randomized controlled trial(RCT) of oral Chinese patent medicines for improving inflammatory response in patients with DN was retrieved from CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane Library, EMbase, Web of Science, and other databases from database inception to October 2022. All investigators independently screened the literature, extracted data, and evaluated the quality.

Metabolite analysis of soybean oil on promoting astaxanthin production of Phaffia rhodozyma.

Background: Astaxanthin is a carotenoid with strong antioxidant property. In addition, it has anti-cancer, anti-tumor, anti-inflammatory and many other functions. The micro-organisms that mainly produce astaxanthin are Haematococcus pluvialis and Phaffia rhodozyma.

Research of Frequency Splitting Caused by Uneven Mass of Micro-Hemispherical Resonator Gyro.

In practical engineering, the frequency splitting of Hemispherical Resonator Gyro (HRG) caused by uneven mass distribution seriously affects the precision of HRG. So, the inherent frequency is an important parameter of micro-Hemispherical Resonator Gyro (m-HRG). In the processing of hemispherical resonator, there are some morphological errors and internal defects in the hemispherical resonator, which affect the inherent frequency and the working mode of m-HRG, and reduce the precision and performance of m-HRG.

ALKBH5 Expression could Affect the Function of T Cells in Systemic Lupus Erythematosus Patients: A Case-control Study.

Background: N6-methyladenosine (m6A) modification is widespread in eukaryotic mRNA, regulated by m6A demethylase, AlkB homolog 5 (ALKBH5). However, the role of m6A in systemic lupus erythematosus (SLE) is still obscure. We explored ALKBH5 expression in SLE patients and its effects on T cells.

Connexin43 inhibition attenuated dopaminergic neuronal loss in the lipopolysaccharide-induced mice model of Parkinson's disease.

Studies using in vitro Parkinson's disease (PD) models have found that lipopolysaccharide (LPS) induced reduction of connexin 43 (Cx43) gap junction communication and elevation of hemichannel function, which could cause neurotoxicity directly and indirectly via excessive ATP and glutamate release. However, in vivo study about Cx43 expression and function, as well as the efficacy of Cx43 inhibition for neuronal survival in PD is lacking. This study aimed to unravel the role of Cx43 in PD and understand the underlying mechanisms using an in vivo PD model.

Titanium dioxide-mediated fatty acids promoted carotenoid synthesis in Phaffia rhodozyma PR106 analyzed whole genome.

Carotenoid, as good colorant and antioxidant, is widely used in the fields of food, medicine and feed. The whole genome of P. rhodozyma PR106 strain with 228.

Waveguide-based total internal reflection fluorescence microscope enabling cellular imaging under cryogenic conditions.

Total internal reflection fluorescence (TIRF) microscopy is an important imaging tool for the investigation of biological structures, especially the study on cellular events near the plasma membrane. Imaging at cryogenic temperatures not only enables observing structures in a near-native and fixed state but also suppresses irreversible photo-bleaching rates, resulting in increased photo-stability of fluorophores. Traditional TIRF microscopes produce an evanescent field based on high numerical aperture immersion objective lenses with high magnification, which results in a limited field of view and is incompatible with cryogenic conditions.

Astaxanthin overproduction of Phaffia rhodozyma PR106 under titanium dioxide stress by transcriptomics and metabolic regulation analysis.

In this study, astaxanthin yield of Phaffia rhodozyma PR106 increased significantly under titanium dioxide (TiO) stress, and the yield of lycopene and β-carotene also increased significantly, as well as the yield of violaxanthin and lutein significantly decreased; in addition, TiO stress promoted cell division and changed cell morphology of PR106. Then, the mechanism of increasing astaxanthin yield was studied by transcriptomics and related metabolic regulation. The results showed that astaxanthin accumulation in PR106 was not directly related to mRNA transcription and post-translational modifications regulation under TiO stress; TiO stress accelerated glucose uptake of yeast, promoted reuse of ethanol, and increased the formation of acetyl-CoA and ATP.

Benzo(a)pyrene exposure in utero exacerbates Parkinson's Disease (PD)-like α-synucleinopathy in A53T human alpha-synuclein transgenic mice.

Background: Previous work indicated that benzo[a]pyrene (B(a)P) exposure in utero might adversely affect neurodevelopment and cause Parkinson's Disease (PD)-like symptoms. However, the effect of utero exposure to B(a)P on PD-like α-synucleinopathy and the mechanism under are unclear.

Objective: The A53T human alpha-synuclein (α-syn) transgenic mice (M83) were used in this study to gain insights into the role of B(a)P exposure in utero in the onset of α-syn pathology and neuronal damage.

Effects of different heat exposure patterns (accumulated and transient) and schizophrenia hospitalizations: a time-series analysis on hourly temperature basis.

Growing studies have shown that high temperature is a potential risk factor of schizophrenia occurrence. Therefore, elaborate analysis of different temperature exposure patterns, such as cumulative heat exposure within a time period and transient exposure at a particular time point, is of important public health significance. This study aims to utilize hourly temperature data to better capture the effects of cumulative and transient heat exposures on schizophrenia during the warm season in Hefei, China.

Diagnostic Value and Clinical Significance of Combined Detection of Serum Markers CYFRA21-1, SCC Ag, NSE, CEA and ProGRP in Non-Small Cell Lung Carcinoma.

Background: The aim of the study is to explore the diagnostic value and clinical significance of combined detection of serum markers CYFRA21-1, SCC Ag, NSE, CEA and ProGRP in non-small cell lung cancer.

Methods: CYFRA21-1, SCC Ag, NSE, CEA, and ProGRP levels of 113 patients with lung cancer, 110 patients with benign lung diseases, and 90 healthy volunteers were detected by electrochemiluminescence assay. The correlations between positive expressions and clinical and pathological parameters were analyzed.

Double-stranded RNA-induced dopaminergic neuronal loss in the substantia nigra in the presence of Mac1 receptor.

Background: The underlying mechanism of viral infection as a risk factor for Parkinson's disease (PD), the second most common neurodegenerative disease, remains unclear.

Objective: We used Mac-1 and gp91 transgene animal models to investigate the mechanisms by which poly I:C, a mimic of virus double-stranded RNA, induces PD neurodegeneration.

Method: Poly I:C was stereotaxically injected into the substantia nigra (SN) of wild-type (WT), Mac-1-knockout (Mac-1) and gp91 -knockout (gp91 ) mice (10 μg/μl), and nigral dopaminergic neurodegeneration, α-synuclein accumulation and neuroinflammation were evaluated.

The value of F-FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation.

The present study aimed to determine whether F-FDG PET/CT performed before and/or after allogeneic hematopoietic stem cell transplantation (allo-HSCT) can predict clinical outcomes in acute leukemia (AL). A total of 79 examinations comprising 72 patients with AL who underwent F-FDG PET/CT before and/or after allo-HSCT were retrospectively enrolled between January 2011 and January 2019. Outcomes were assessed using overall survival (OS) and disease-free survival (DFS).

Astaxanthin overproduction and proteomic analysis of Phaffia rhodozyma under the oxidative stress induced by TiO.

This study analyzed the effect of TiO on the growth and astaxanthin yield of P. rhodozyma PR106. Subsequently, proteomics method was used to analyze the proteins changes of the strain under TiO treatment, to investigate the metabolic mechanism of the active oxygen generator TiO promoting the astaxanthin synthesis in P.

Prognostic value of baseline F-FDG PET/CT metabolic parameters in paediatric lymphoma.

Introduction: In the present study, we aimed to investigate the prognostic value of metabolic parameters, including maximum standardized uptake value (SUV ), total metabolic tumour volume (tMTV) and total lesion glycolysis (TLG), measured at baseline F-FDG PET/CT in paediatric lymphoma.

Methods: From March 2013 to April 2019, 47 patients with paediatric lymphoma, including 38 males and nine females with an average age of 14.87 years, who underwent F-FDG PET/CT scan prior to treatment were retrospectively included in this study.

Au nanocages saturable absorber for 3-µm mid-infrared pulsed fiber laser with a wide wavelength tuning range.

Au nanocages (Au-NCs) have attracted wide attention as low-dimensional materials with broadband absorption, ultrafast optical response, large third-order optical nonlinearity coefficient, and high photothermal stability and thermal tolerance. By employing Au-NCs as saturable absorbers, we demonstrate a widely tunable passively Q-switched erbium-doped fluoride fiber laser at the wavelength of 2.8 µm.

Enhancement of carotenoid biosynthesis in PR106 under stress conditions.

Carotenoids have good biological activity in antioxidant, anti-aging and scavenging harmful free radicals. In this study, we screened a strain that produced carotenoids, and selected a stress condition which significantly improved carotenoids content. The strain was identified as PR106.