Parental/guardians' satisfaction with vaccination service and its associated factors: a cross-sectional study from Eastern China.

Background: Vaccination is a simple and effective preventative measure against infections and diseases among populations, especially children. This study aimed to evaluate parental/guardians' satisfaction with vaccination services and examine its associated factors in China.

Methods: This study used mixed methods of quantitative and qualitative research methods.

Cord-Blood Engraftment Using an Enhanced Dual-Conditioning Regimen for Malignant Hematologic Diseases.

To explore a more effective conditioning regimen for umbilical cord blood transplantation (UCBT) to treat hematologic malignancies, we conducted a cohort study of a fludarabine/busulfan/cytarabine plus cyclophosphamide 200 mg/kg regimen. Forty-two consecutive patients with leukemia, myelodysplastic syndrome, or lymphoma received the regimen. The median number of infused total nucleated cells per kilogram was 5.

Identifying patients with major depressive disorder based on tryptophan hydroxylase-2 methylation using machine learning algorithms.

Objectives: This study aimed to identify patients with major depressive disorder (MDD) by developing different machine learning (ML) models based on tryptophan hydroxylase-2 (TPH2) methylation and environmental stress.

Methods: The data were collected from 291 patients with MDD and 100 healthy control participants: individual basic information, the Negative Life Events Scale (NLES) scores, the Childhood Trauma Questionnaire (CTQ) scores and the methylation level at 38 CpG sites in TPH2. Information gain was used to select critical input variables.

circAMOTL1L Suppresses Renal Cell Carcinoma Growth by Modulating the miR-92a-2-5p/KLLN Pathway.

Accumulating evidence indicates that the dysregulation of circular RNAs (circRNAs) contributes to tumor progression; however, the regulatory functions of circRNAs in renal cell carcinoma (RCC) remain largely unknown. In this study, the function and underlying mechanism of circAMOTL1L in RCC progression were explored. qRT-PCR showed the downregulation of circAMOTL1L in RCC tissues and cell lines.

Effect of Qizhitongluo capsule on lower limb rehabilitation after stroke: A randomized clinical trial.

Background: An individual's level of lower limb motor function is associated with his or her disability level after stroke, and motor improvement may lead to a better prognosis and quality of life. Data from animal models show that Qizhitongluo (QZTL) capsule facilitates recovery after focal brain injury. We aimed to validate the efficacy and safety of the QZTL capsule for promoting lower limb motor recovery in poststroke patients.

Viscoelastic Mechanical Responses of HMAP under Moving Load.

In order to represent the mechanical response laws of high-modulus asphalt pavement (HMAP) faithfully and objectively, the viscoelasticity of high-modulus asphalt mixture (HMAM) was considered, and the viscoelastic mechanical responses were calculated systematically based on moving load by numerical simulations. The performances of the HMAP in resistance to the deformation and the cracking at the bottom layer were compared with the ordinary asphalt pavement. Firstly, Lubao and Honeywell 7686 (H7686) were selected as the high modulus modifiers.