Classification of molecular subtypes for colorectal cancer and development of a prognostic model based on necroptosis-related genes.

Background: Necroptosis could regulate immunity in cancers, and stratification of colorectal cancer (CRC) subtypes based on key genes related to necroptosis might be a novel strategy for CRC treatment.

Method: The RNA-sequencing data of CRC and other 31 types of cancers were obtained from The Cancer Genome Atlas (TCGA) database. Consensus clustering was performed based on protein-coding genes (PCGs) related to necroptosis score calculated by single sample gene set enrichment analysis (ssGSEA).

Single-cell data revealed CD14-type and FCGR3A-type macrophages and relevant prognostic factors for predicting immunotherapy and prognosis in stomach adenocarcinoma.

Background: Stomach adenocarcinoma (STAD) exhibits profound tumor heterogeneity and represents a great therapeutic challenge. Single-cell sequencing technology is a powerful tool to identify characteristic cell types.

Methods: Single-cell sequencing data (scRNA-seq) GSE167297 and bulk RNA-seq data from TCGA, GTEx, GSE26901 and GSE15459 database were included in this study.

Temporal and spatial changes and influencing factors of low-carbon economy efficiency in China.

Low-carbon development has always been an important focus of China's economic transformation. In order to promote the development of low-carbon economy, this study used SBM-DEA model to evaluate China's provincial LCEE from 2005 to 2019, studied its temporal and spatial evolution law, used spatial autocorrelation to explore the correlation of China's provincial LCEE, and explored the key influencing factors of LCEE with Tobit model. The empirical results show that the LCEE of most provinces in China is declining, and there are significant differences among different regions in China.

Spatiotemporal Characteristics and Influencing Factors of Tourism-Urbanization-Technology-Ecological Environment on the Yunnan-Guizhou-Sichuan Region: An Uncoordinated Coupling Perspective.

The tourism, urbanization, technology, and the ecological environment both promote and restrict each other. Coordinating the relationship between the four is of great significance to the realization of high-quality sustainable regional development. Taking the Yunnan-Guizhou-Sichuan region as an example, this paper constructs an uncoordinated coupling model for the tourism-urbanization-technology-ecological environment system.

Comparison of safety, effectiveness and serum inflammatory factor indexes of versus triple viable in treating children with chronic diarrhea: a randomized trial.

Background: Diarrhea is common in children under 5 years of age and is an important public health problem in China. CD is the main obstacle to the growth and development of children, which brings a great burden to individuals, families and society. The objective of this work is to study the efficacy and safety of versus triple viable in the treatment of CD in children.