Privacy preserving IoT-based crowd-sensing network with comparable homomorphic encryption and its application in combating COVID19.

IoT-based crowd-sensing network, which aims to achieve data collection and task allocation to mobile users, become more and more popular in recent years. This data collected by IoT devices may be private and directly transmission of these data maybe incur privacy leakage. With the help of homomorphic encryption (HE), which supports the additive and/or multiplicative operations over the encrypted data, privacy preserving crowd-sensing network is now possible.

ERRγ-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element.

The estrogen-related receptor (ERR) family members are reported to bind DNA elements as either monomer or dimer. However, to date, only one solution NMR structure of ERRβ in complex with a half-site DNA element has been reported. To better understand the DNA regulation mechanism, we determined the crystal structure of ERRγ-DBD bound to a natural DR1 element in Pla2g12b promoter to 2.

Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation.

Elaiophylin (Ela), a unique 16-membered symmetric macrodiolide antibiotic, displays broad biological activity. Two rare 2-deoxy-L-fucose moieties at the ends of Ela are critical for its activity. Previously, elaiophylin glycosyltransferase (ElaGT) was identified as the enzyme that is responsible for the symmetric glycosylation of Ela, acting as a potential enzymatic tool for enhancing the diversity and activity of Ela.

Molecular Basis for PI(3,5)P Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation.

Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P) is an essential phosphoinositide required for endosome homeostasis and sorting for lysosomal degradation; however, the underlying mechanisms, especially in mammals, remain elusive or unexplored. Here we determined a structure of PI(3,5)P bound to Sorting Nexin 11 (SNX11) with an opened PPII-C loop. We also obtained an SNX11 structure with its PPII-C in "closed" form that serves as a potential PI3P-binding model.