Assessing foodborne health risks from dietary exposure to antibiotic resistance genes and opportunistic pathogens in three types of vegetables: An in vitro simulation of gastrointestinal digestion.

Foodborne health risks posed by antibiotic resistant genes (ARGs) and pathogenic bacteria have garnered increasing global attention. However, the patterns of their propagation and reduction, as well as the resulting health risks in the human gastrointestinal tract, remain unknown. We employed leafy vegetables (water spinach), solanaceous vegetables (pepper), and root vegetables (radish) to investigate the propagation and reduction patterns of ARGs and pathogenic bacteria within an in vitro simulated digestion system.

Acid-modified corn straw biochar immobilized Pseudomonas hibiscus CN-1 facilitated the bioremediation of carbendazim-contaminated soil.

Carbendazim application in agroecosystems has posed potential threats to ecosystems and human health. The utilization of biochar-based materials for immobilizing microorganisms offers a sustainable strategy for effective bioremediation. In this study, a novel highly efficient carbendazim-degrading bacterium Pseudomonas hibiscus CN-1 was isolated and immobilized using corn straw-based biochar as a carrier.

Dinitrogen silylation catalyzed by silylene cobalt(I) and silylene iron(I) chlorides.

In this contribution, Co(PMe)Cl (1), bis(silylene) cobalt chlorides Co(LSi:)(PMe)Cl (LSi: = {PhC(NBu)}SiCl (2); {-CHCHC(NBu)}SiCl (3); and {-BuCHC(NBu)}SiCl (4)) and bis(silylene) iron chlorides Fe(LSi:)(PMe)Cl (LSi: = {PhC(NBu)}SiCl (5); {-CHCHC(NBu)}SiCl (6); {-BuCHC(NBu)}SiCl (7) and Fe(PMe)Cl (8)) were synthesized to study the effects of different metals and silylene ligands on the catalytic activity of complexes 1-8 in dinitrogen silylation reaction. The experimental results indicate that there is no substantial difference in catalytic activity between the phosphine cobalt complex 1 and the silylene cobalt chlorides 2-4 although the cobalt silylene complex 2 has slightly better catalytic activity than complexes 1, 3 and 4 in the dinitrogen silylation. Silylene iron complexes 5-7 are more active than the phosphine iron complex 8.

In-situ enrichment of ARGs and their carriers in soil by hydroxamate siderophore: A promising biocontrol approach for source reduction.

Pathogenic microorganisms with antibiotic resistance genes (ARGs) pose a serious threat to public health and soil ecology. Although new drugs and available antibacterial materials can kill ARG carriers but accidentally kill beneficial microorganisms. Therefore, the rapid enrichment and separation of ARGs and their carriers from soil is becoming an important strategy for controlling the diffusion of ARGs.

Effect of magnesium level before allogeneic hematopoietic cell transplantation on outcome in acute leukemia.

This study assessed the effect of serum magnesium levels and their role in the outcome of allogeneic hematopoietic cell transplantation (allo-HSCT) in acute leukemia. Fifty-four patients with acute leukemia who underwent allo-HSCT were divided into two groups according to their serum magnesium levels before transplantation. The results showed that serum magnesium level is an independent factor influencing the prognosis of patients undergoing allo-HSCT.

Research Progress of Pyroptosis in Diabetic Kidney Disease.

Pyroptosis, known as one typical mode of programmed cell death, is generally characterized by the cleaved gasdermin family (GSDMs) forming pores in the cell membrane and inducing cell rupture, and the activation of aspartate-specific proteases (caspases) has also been found during this process. Diabetic Kidney Disease (DKD) is caused by the complication of diabetes in the kidney, and the most important kidney's function, Glomerular Filtration Rate (GFR), happens to drop to less than 90% of its usual and even lead to kidney failure in severe cases. The persistent inflammatory state induced by high blood glucose implies the key pathology of DKD, and growing evidence shows that pyroptosis serves as a significant contributor to this chronic immune-mediated inflammatory disorder.

A Review of Remediation Strategies for Diphenyl Ether Herbicide Contamination.

In agriculture, diphenyl ether herbicides are a broad-spectrum family of pesticides mainly used to control annual weeds in agriculture. Although diphenyl ether herbicides have a long-lasting effect in weed control, they can also be harmful to succeeding crops, as well as to the water and soil environment. Residual herbicides can also harm a large number of non-target organisms, leading to the death of pest predators and other beneficial organisms.

Ethnic disparities and temporal trends in health resource allocation: a retrospective decadal analysis in Sichuan, a multi-ethnic Province of Southwest China (2009-2019).

Background: Research on health resource allocation trends in ethnic minority and impoverished areas in China is limited since the 2009 Medical Reform. This study aimed to investigate the variations and inequalities in health resource distribution among ethnic minority, poverty-stricken, and non-minority regions in Sichuan Province, a multi-ethnic province in Southwest China, from 2009 to 2019.

Methods: The numbers of beds, doctors and nurses were retrospectively sourced from the Sichuan Health Statistics Yearbook between 2009 and 2019.

UiO-66-NH Metal-Organic Framework for the Detection of Alzheimer's Biomarker Aβ (1-42).

Neurodegenerative disorders pose a significant challenge to global healthcare, with Alzheimer's disease (AD) being one of the most prevalent forms. Early and accurate detection of amyloid-β (Aβ) (1-42) monomers, a key biomarker of AD pathology, is crucial for effective diagnosis and intervention of the disease. Current gold standard detection techniques for Aβ include enzyme-linked immunosorbent assay and surface plasmon resonance.

Research Progress of Pyroptosis in Fatty Liver Disease.

Fatty liver disease (FLD) is a clinical and pathological syndrome characterized by excessive fat deposition and even steatosis in hepatocytes. It has been proven that liver inflammation induced by fat and its derivatives are involved in the pathogenesis of FLD, while the precise mechanism still remains poorly understood. Pyroptosis is programmed inflammatory cell death driving cell swelling and membrane rupture.

Directivity Modeling and Simulation Analysis of a Novel Structure MEMS Piezoelectric Vector Hydrophone.

In this paper, a novel dual-mass MEMS piezoelectric vector hydrophone is proposed to eliminate the transverse effect and solve the problem of directivity offset in traditional single-mass MEMS piezoelectric vector hydrophones. The reason for the directional offset of the traditional single-mass cantilever MEMS piezoelectric vector hydrophone is explained theoretically for the first time, and the angle of the directional offset is predicted successfully. Both analytical and finite element methods are employed to analyze the single-mass and dual-mass cantilever MEMS piezoelectric vector hydrophone.

Effects of silylene ligands on the performance of carbonyl hydrosilylation catalyzed by cobalt phosphine complexes.

In order to study the effects of silylene ligands on the catalytic activity of carbonyl hydrosilylation catalyzed by cobalt phosphine complexes, readily available model catalysts are required. In this contribution, a comparative study of the hydrosilylation of aldehydes and ketones catalyzed by tris(trimethylphosphine) cobalt chloride, CoCl(PMe) (1), and bis(silylene) cobalt chloride, Co(LSi:)(PMe)Cl (2, LSi: = {PhC(NBu)}SiCl), is presented. It was found that both complexes 1 and 2 are good catalysts for the hydrosilylation of aldehydes and ketones under mild conditions.

Control over Selectivity in Alkene Hydrosilylation Catalyzed by Cobalt(III) Hydride Complexes.

Two new bisphosphine [PCP] pincer cobalt(III) hydrides, [(L)Co(PMe)(H)(Cl)] (, = 2,6-((PhP)(Et)N)CH) and [(L)Co(PMe)(H)(Cl)] (, = 2,6-((PrP)(Et)N)CH), as well as one new bissilylene [SiCSi] pincer cobalt(III) hydride, [(L)Co(PMe)(H)(Cl)] (, = 1,3-((PhC(BuN)Si)(Et)N)CH), were synthesized by reaction of the corresponding protic [PCP] or [SiCSi] pincer ligands , and with CoCl(PMe). Despite the similarities in the ligand scaffolds, the three cobalt(III) hydrides show remarkably different performance as catalysts in alkene hydrosilylation. Among the PCP pincer complexes, has higher catalytic activity than complex , and both catalysts afford -Markovnikov selectivity for both aliphatic and aromatic alkenes.

PZT-Film-Based Piezoelectric Micromachined Ultrasonic Transducer with I-Shaped Composite Diaphragm.

We proposed a PZT-film-based piezoelectric micromachined ultrasonic transducer (pMUT) with an I-shaped composite diaphragm to improve the sensitivity and resonant frequency of pMUTs with the same diaphragm area. The finite element method (FEM) simulation results indicated that the pMUT with an I-shaped composite diaphragm had relatively high sensitivity and resonant frequency. The pMUT with an I-shaped diaphragm had a 36.

Effect of different carbon sources on sulfate reduction and microbial community structure in bioelectrochemical systems.

Microbial electrolysis cells (MECs) have rapidly developed into a promising technology to treat sulfate-rich wastewater that lacks electron donors. Hence, a better understanding of the effect on the microbial community structure caused by different sources in bioelectrochemical systems is required. This study sought to investigate the effect of different carbon sources (NaHCO, ethanol, and acetate were employed as sole carbon source respectively) on the performance of sulfate-reducing biocathodes.

Nanoparticle-based colorimetric sensors to detect neurodegenerative disease biomarkers.

Neurodegenerative disorders (NDDs) are progressive, incurable health conditions that primarily affect brain cells, and result in loss of brain mass and impaired function. Current sensing technologies for NDD detection are limited by high cost, long sample preparation, and/or require skilled personnel. To overcome these limitations, optical sensors, specifically colorimetric sensors, have garnered increasing attention towards the development of a cost-effective, simple, and rapid alternative approach.

Influence of SLCO1B1 521T>C, UGT2B7 802C>T and IMPDH1 -106G>A Genetic Polymorphisms on Mycophenolic Acid Levels and Adverse Reactions in Chinese Autoimmune Disease Patients.

Introduction: Mycophenolate mofetil (MMF), a new type of immunosuppressant, has emerged as a frontline agent for treating autoimmune diseases. Mycophenolic acid (MPA) is an active metabolite of MMF. MPA exposure varies greatly among individuals, which may lead to adverse drug reactions such as gastrointestinal side effects, infection, and leukopenia.

Selectivity Reverse of Hydrosilylation of Aryl Alkenes Realized by Pyridine N-Oxide with [PSiP] Pincer Cobalt(III) Hydride as Catalyst.

Six silyl cobalt(III) hydrides - with [PSiP] pincer ligands having different substituents at the P and Si atoms ([(2-PhPCH)MeSiCo(H)(Cl)(PMe)] (), [(2-PhPCH)HSiCo(H)(Cl)(PMe)] (), [(2-PhPCH)PhSiCo(H)(Cl)(PMe)] (), [(2-PrPCH)HSiCo(H)(Cl)(PMe)] (), [(2-PrPCH)MeSiCo(H)(Cl)(PMe)] (), and [(2-PrPCH)PhSiCo(H)(Cl)(PMe)] ()) were synthesized through the reactions of the ligands (-) with CoCl(PMe) via Si-H bond cleavage. Compounds - have catalytic activity for alkene hydrosilylation, and among them, complex is the best catalyst with excellent -Markovnikov regioselectivity. A silyl dihydrido cobalt(III) complex from the reaction of with PhSiH was isolated, and its catalytic activity is equivalent to that of complex .

Resistin Gene Polymorphism Is an Influencing Factor of Postoperative Pain for Chinese Patients.

Background: Gene polymorphism is an important factor affecting the efficacy and dosage of opioids. A recent study showed RETN rs3745367 was associated with postoperative pain intensity. OPRM1 gene was confirmed to affect the postoperative analgesic consumption of morphine and other opioids.

The Effect of Substituents on the Formation of Silyl [PSiP] Pincer Cobalt(I) Complexes and Catalytic Application in Both Nitrogen Silylation and Alkene Hydrosilylation.

Four different [PSiP]-pincer ligands - ((2-PhPCH)SiHR (R = H () and Ph ()) and (2-PrPCH)SiHR' (R' = Ph () and H ()) were used to investigate the effect of substituents at P and/or Si atom of the [PSiP] pincer ligands on the formation of silyl cobalt(I) complexes by the reactions with CoMe(PMe) via Si-H cleavage. Two penta-coordinated silyl cobalt(I) complexes, (2-PhPCH)HSiCo(PMe) () and (2-PhPCH)PhSiCo(PMe) (), were obtained from the reactions of and with CoMe(PMe), respectively. Under similar reaction conditions, a tetra-coordinated cobalt(I) complex (2-PrPCH)PhSiCo(PMe) () was isolated from the interaction of with CoMe(PMe).

Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide.

The amyloid aggregation of peptides and proteins is a hallmark of neurological disorders and type 2 diabetes. Human islet amyloid polypeptide (IAPP), co-secreted with insulin by pancreatic β-cells, plays dual roles in both glycemic control and the pathology of type 2 diabetes. While IAPP can activate the NLRP3 inflammasome and modulate cellular autophagy, apoptosis and extracellular matrix metabolism, no data is available concerning intracellular protein expression upon exposure to the polypeptide.

Perioperative predictors of moderate and severe postoperative pain in idiopathic scoliosis patients following spinal correction and fusion operations.

To investigate the predictive factors of pain intensity during the first 48 hours after spinal correction and fusion operations for idiopathic scoliosis patients.A total of 290 scoliosis patients who underwent posterior spinal instrumentation and fusion operations were enrolled in this study. A standard surgical and analgesic method was implemented for all participants and pain intensity was evaluated at fixed times within 48 hours after the operation.

Functions of Wnt signaling pathway in hair cell differentiation and regeneration.

Wnt signaling pathway plays important roles in the development and homeostasis of multicellular organisms. Through their bindings with the Frizzled receptors, the Wnt ligands regulate a wide range of developmental processes, such as axis patterning, cell division, and cell fate specification. Wnt signaling plays vital roles in the development of inner ear of the mouse.

Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation.

Nuclear modifier gene(s) was proposed to modulate the phenotypic expression of mitochondrial DNA mutation(s). Our previous investigations revealed that a nuclear modifier allele (A10S) in TRMU (methylaminomethyl-2-thiouridylate-methyltransferase) related to tRNA modification interacts with 12S rRNA 1555A→G mutation to cause deafness. The A10S mutation resided at a highly conserved residue of the N-terminal sequence.