The effect of repetitive magnetic stimulation on neuronal apoptosis and PI3K/Akt protein expression in rats with incomplete spinal cord injury.

The pathological and physiological process of spinal cord injury is complex, and there is currently no effective treatment method. Magnetic stimulation is an emerging electromagnetic therapy method in recent years, and studies have shown its potential to reduce cell apoptosis. This study used an improved Allen's method to replicate an incomplete spinal cord injury rat model, and repetitive magnetic stimulation (rMS) intervention was performed on the rats for 21 days.

Effects of transcranial magnetic stimulation on axonal regeneration in the corticospinal tract of female rats with spinal cord injury.

Background: This study investigates the potential of transcranial magnetic stimulation (TMS) to enhance spinal cord axon regeneration by modulating corticospinal pathways and improving motor nerve function recovery in rats with spinal cord injury (SCI).

New Method: TMS is a non-invasive neuromodulation technique that generates a magnetic field to activate neurons in the brain, leading to depolarization and modulation of cortical activity. Initially utilized for brain physiology research, TMS has evolved into a diagnostic and prognostic tool in clinical settings, with increasing interest in its therapeutic applications.

Associations of cognitive impairment and functional limitation with all-cause mortality risk in older adults: A population-based study from the National Health and Nutrition Examination Survey.

Cognitive impairment and functional limitation are commonly observed in older adults. They have a complex correlation, and both are risk factors for mortality. This prospective cohort study aimed to explore the independent and joint impact of cognitive impairment and functional limitations on all-cause mortality in older adults.

Body Weight Support Treadmill Training Combined With Sciatic Nerve Electrical Stimulation Ameliorating Motor Function by Enhancing PI3K/Akt Proteins Expression via BDNF/TrkB Signaling Pathway in Rats with Spinal Cord Injury.

Objective: To investigate the effects of body weight support treadmill training (BWSTT) and sciatic nerve electrical stimulation (SNES) on motor function recovery in spinal cord injury (SCI) rats and its possible mechanism.

Methods: Modified Allen's method was utilized for T10 incomplete SCI. The Basso-Beattie-Bresnahan (BBB) score and modified Tarlov score were applied to assess motor function.

Safety and effectiveness for oral intake of carbohydrate-rich drink at preoperative 2 hours before painless colonoscopy.

The aim of this study was to evaluate the feasibility, safety, and optimal dose of oral intake of carbohydrate-rich drinks 2 hours before painless colonoscopy. All patients receiving painless colonoscopy were randomly divided into 3 groups: control group (no carbohydrate-rich drink, n = 33), low-dose group (5 mL/kg carbohydrate-rich drink, n = 30), and high-dose group (8 mL/kg carbohydrate-rich drink, n = 30). Use of vasoactive drugs, the visual analog scale including thirst and hunger, degree of satisfaction, the time required for Modified Post Anesthetic Discharge Scoring System scale, first urination time, electrolyte level (sodium, potassium, and calcium), and blood glucose level were also determined.

The effect of intravenous infusion on the rapid recovery of elderly patients treated with painless colonoscopy and the value of ultrasonic measurement of the inferior vena cava diameter in guiding intravenous infusion.

Background: Elderly patients with painless colonoscopy often complain listlessness, fatigue when they left postanesthesia care unit (PACU). These patients also commonly occur hypotension during anesthesia. However, intravenous infusion and blood volume assessment are seldom performed in elderly patients.

Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.

Aims: Cardiac dysfunction is the main cause of multi-organ failure following sepsis within critical care units. The present study aimed to investigate the effects of the small molecule inhibition of cyclic GMP-AMP synthase (cGAS), RU.521, on cardiac function in mice with sepsis.

Over-Expression of PTEN Suppresses the Proliferation and Migration of Fibroblast-Like Synoviocytes in Adjuvant-Induced Arthritis.

Background/aims: Rheumatoid arthritis (RA) is characterized by a tumor-like expansion of the synovium and the subsequent destruction of adjacent articular cartilage and bone. Recent studies have shown that phosphatase and tension homolog deleted on chromosome 10 (PTEN) might contribute to the surviva of fibroblast-like synoviocytes (FLSs) and the production of pro-inflammatory cytokines in RA. The purpose of this study was to explore the functions and underlying mechanisms of PTEN in the proliferation and migration of FLSs.

[Direct determination of four components in compound paracetamol and diphenhydramine tablets by wide bore capillary gas chromatography].

A gas chromatographic method for the simultaneous determination of paracetamol (PAR), caffeine (CAF), diphenhydramine hydrochloride (DPH) and ephedrine hydrochloride (EPD) in Compound Paracetamol and Diphenhydramine Tablets has been developed. The separation of several components was achieved on a wide bore capillary column HP-1 (10 m x 0. 53 mm, 2.

Fluorescence spectroscopy determination of fluoroquinolones by charge-transfer reaction.

The charge-transfer (CT) reaction between chloranilic acid (CL) as a pi-electron acceptor and lomefloxacin (LOM), fleroxacin (FLX), ciprofloxacin (CPFX), norfloxacin (NOR) as electron donor have been studied by fluorimetry. The CT complexes have stable purple color in acetone solution and the fluorescence intensity of the CT complexes was enhanced in 4-14 fold higher than that of the four fluoroquinolones (FQS) itself, therefore a new spectrofluorimetric method with simple, rapid, accurate, high sensitivity and good selectivity for determination of the four FQS has been developed. The method was applied for determination of drugs (LOM, FLX, CPFX and NOR) in tablets with mean percentage accuracies 99.

[Preparation of chloro-sparfloxacin and its fluorescence behavior].

Sparfloxacin (SPFX) can be oxidized by nitrous acid then react with chlorohydric acid further to form a strong fluorescence substance in acid media. The molecular structure is identified by elemental analysis, IR, MS and fluorescence spectra. The emission properties of sparfloxacin and chloro-sparfloxacin are greatly distinct, the fluorescence of sparfloxacin is so weak that it can not be determined by means of fluorescence spectra, but the fluorescence intensity of the new substance is 110 fold more than that of sparfloxacin itself.

[Study on the direct determination of lomefloxacin in urine by derivative-synchronous fluorescence].

The LMX fluorescence properties at various pH of media were studied. The experiments indicated that LMX fluorescence emission wavelength is red shifted 40 nm at pH value of 3.3.