Lamotrigine decreases MRP8 and IL-7 in rat models of intractable epilepsy secondary to focal cortical dysplasia.

The aim of the present study was to examine the effect of lamotrigine and the expression of myeloid-related protein 8 (MRP8) and interleukin-7 (IL-7) in the treatment of focal cortical dysplasia with secondary intractable epilepsy. In this study, rats with focal cortical dysplasia with secondary intractable epilepsy (constructed by our laboratory) were selected and used for experimentation, 21-day Sprague-Dawley rats were randomly divided into the control group (38 rats), the observation group I (39 rats), and the observation group II (38 rats). Rats in the observation group I received daily intraperitoneal injection of 0.

Neurological teratogenic effects of antiepileptic drugs during pregnancy.

Epilepsy is one of the few neurologic disorders that requires a constant treatment during pregnancy. Epilepsy affects 0.3-0.

Curcumin improves neurofunctions of 6-OHDA-induced parkinsonian rats.

Our previous study has demonstrated that curcumin (CM), a natural ingredient isolated from Zingiberaceae, exerts the effect of inhibiting hippocampal injury in 6-hydroxydopamine (6-OHDA)-induced parkinsonian rat. However, the potential effect of CM on 6-OHDA-injured substantia nigra (SN) needs to be investigated. This study aimed to further evaluate the therapeutic effectiveness of CM against damaged SN in rats.