Low-dose Cisplatin Induces Tumor Growth Mobilization of Proangiogenic Bone Marrow-derived Cells in Mouse Models.

Background/aim: It is generally accepted that low-dose metronomic (LDM) chemotherapy mostly exerts its antitumor effects by inhibiting tumor angiogenesis. However, there is some evidence that LDM chemotherapy subsequently promotes tumor angiogenesis under certain regimens in animal models. The mechanisms responsible for these contradictory results are unclear.