METTL3-mediated m A methylation of TRAF5 inhibits lung adenocarcinoma cell metastasis via activation of the PI3K/AKT/NF-κB signaling pathway.

Tumor necrosis factor receptor-associated factor 5 (TRAF5) has been implicated in the pathogenesis of human malignancies. This work aimed to clarify the role of TRAF5 in lung adenocarcinoma (LUAD) progression. Herein, we uncovered that TRAF5 level was reduced in LUAD tissues.

CdSe/ZnS QDs embedded polyethersulfone fluorescence composite membrane for sensitive detection of copper ions in various drinks.

The copper ion was detected rapidly by a novel sensing membrane in this paper for its damage to health and the environment. CdSe/ZnS QDs modified polyethersulfone membrane (QDs@PESM) was made by phase-inversion method using a membrane separation technique and quantum dots (QDs). When the sample passed through the membrane, the copper ions in the sample caused the membrane's fluorescence to be quenched.

Synthesis and Characteristics of a pH-Sensitive Sol-Gel Transition Colloid for Coal Fire Extinguishing.

Coal fires, most of which are triggered by the spontaneous combustion of coal, cause a huge waste of resources and release poisonous and harmful substances into the environment, seriously threatening the safety of industrial production. Gel flame retardant plays a core role in coal fire prevention and extinguishing. Most gel flame retardants used in coal fires possess good sealing and oxygen isolation properties, but it is difficult for them to flow deep into fire areas due to their low fluidity.

Dissipation of sixteen pesticide residues from various applications of commercial formulations on strawberry and their risk assessment under greenhouse conditions.

Twelve commercial pesticide formulations containing sixteen active ingredients were applied on greenhouse strawberries at recommended and double doses. The dynamics and dietary risk analysis were investigated. A modified QuEChERS method based on the use of multi-walled carbon nanotubes (MWCNTs) as adsorbent followed by LC-MS/MS and GC-MS/MS detection was utilized for sample analysis.

Wire like diplatinum, triplatinum, and tetraplatinum complexes featuring X[PtC[triple bond, length as m-dash]CC[triple bond, length as m-dash]CC[triple bond, length as m-dash]CC[triple bond, length as m-dash]C]PtX segments; iterative syntheses and functionalization for measurements of single molecule properties.

Reaction of (p-tol3P)2PtCl2 and Me3Sn(C[triple bond, length as m-dash]C)2SiMe3 (1 : 1/THF/reflux) gives monosubstituted trans-Cl(p-tol3P)2Pt(C[triple bond, length as m-dash]C)2SiMe3 (63%), which with wet n-Bu4N+ F- yields trans-Cl(p-tol3P)2Pt(C[triple bond, length as m-dash]C)2H (2, 96%). Hay oxidative homocoupling (O2/CuCl/TMEDA) gives all-trans-Cl(p-tol3P)2Pt(C[triple bond, length as m-dash]C)4Pt(Pp-tol3)2Cl (3, 68%). Reaction of 3 and Me3Sn(C[triple bond, length as m-dash]C)2SiMe3 (1 : 1/rt) affords monosubstituted all-trans-Cl(p-tol3P)2Pt(C[triple bond, length as m-dash]C)4Pt(Pp-tol3)2(C[triple bond, length as m-dash]C)2SiMe3 (46%), which is converted by a similar desilylation/homocoupling sequence to all-trans-Cl[(p-tol3P)2Pt(C[triple bond, length as m-dash]C)4]3Pt(Pp-tol3)2Cl (7; 79%).

Molecular wires in single-molecule junctions: charge transport and vibrational excitations.

We investigate the effect of vibrations on the electronic transport through single-molecule junctions, using the mechanically controlled break junction technique. The molecules under investigation are oligoyne chains with appropriate end groups, which represent both an ideally linear electrical wire and an ideal molecular vibrating string. Vibronic features can be detected as satellites to the electronic transitions, which are assigned to longitudinal modes of the string by comparison with density functional theory data.

Cubic nonlinear optical properties of platinum-terminated polyynediyl chains.

The wavelength dependence of the cubic nonlinearity of ligated platinum-terminated polyynes trans, trans-{(p-MeC6H4)3P}2(p-MeC6H4)Pt(C[triple bond]C)n Pt(p-C6H4Me){P(p-C6H4Me)3}2 (n = 3-6, 8, 10, 12) has been examined by femtosecond Z-scan studies in the wavelength range 520-1500 nm and the results rationalized by density functional theory calculations on the model complexes trans, trans-(H3P)2(C6H5)Pt(C[triple bond]C)n Pt(C6H5)(PH3)2 (n = 2-8, 10, 12). Although the final states for one- and two-photon transitions are not the same in these centrosymmetric molecules, the Z-scan studies reveal coincidences in one-photon absorption with features in the frequency dependencies of both real and imaginary parts of the cubic hyperpolarizability, as well as inflections in the frequency dependencies of the real part of gamma that correspond to resonances in the imaginary part of gamma. The theoretical studies suggest that the linear absorption spectra are dominated by X(1)A g --> n(1)B(3u) transitions, with the first state of B(3u) symmetry playing a steadily diminishing role upon oligoyne chain lengthening.

Photophysics of diplatinum polyynediyl oligomers: chain length dependence of the triplet state in sp carbon chains.

The series of polyynes with the structure trans, trans-[Ar-Pt(P 2)-(C[triple bond]C) n -Pt(P 2)-Ar], where P = tri( p-tolyl)phosphine, Ar = p-tolyl, and n = 3, 4, 5, 6 (6, 8, 10, 12 sp carbon atoms), has been subjected to a comprehensive photophysical investigation. At low temperature ( T < 140 K) in a 2-methyltetrahydrofuran (MTHF) glass, the complexes exhibit moderately efficient phosphorescence appearing as a series of narrow (fwhm < 200 cm (-1)) vibronic bands separated by ca. 2100 cm (-1).

A synthetic breakthrough into an unanticipated stability regime: a series of isolable complexes in which C6, C8, C10, C12, C16, C20, C24, and C28 polyynediyl chains span two platinum atoms.

The reaction of trans-[PtCl(p-tol){P(p-tol)3}2] (PtCl) and H(C[triple chemical bond]C)2H (cat. CuI, HNEt2) gives PtC4H (82 %), which can be cross-coupled with excess HC[triple chemical bond]CSiEt3 (acetone, O2, CuCl/TMEDA; Hay conditions) to yield PtC6Si (77 %). The addition of nBu4N+F- in wet acetone gives PtC6H (84 %), and further addition of ClSiMe3 (F- scavenger) and excess HC[triple chemical bond]CSiEt3 (Hay conditions) yields PtC(8)Si (23 %).

A synthetic breakthrough into an unanticipated stability regime: readily isolable complexes in which C16-C28 polyynediyl chains span two platinum atoms.

The oxidative cross-coupling of trans-(p-tol)(p-tol3P)2Pt(CC)2H (PtC4H) and excess H(CC)2SiEt3 (O2, cat. CuCl, TMEDA, acetone; Hay conditions) gives PtC8Si (29%), PtC12Si (30%), and PtC16Si (1%; Si = SiEt3). The less stable PtC6H is generated in situ from PtC6Si and n-Bu4N+F-; following the addition of ClSiMe3 (F- scavenger) and excess H(CC)2SiEt3, the Hay conditions afford PtC10Si (59%) and PtC14Si (7%).