Postmortem Diffusion of Aconitum Alkaloids and Their Metabolites in Rabbits.

Objectives: To explore the postmortem diffusion rule of Aconitum alkaloids and their metabolites in poisoned rabbits, and to provide a reference for identifying the antemortem poisoning or postmortem poisoning of Aconitum alkaloids.

Methods: Twenty-four rabbits were sacrificed by tracheal clamps. After 1 hour, the rabbits were administered with aconitine LD in decocting aconite root powder by intragastric administration.

Design and Construction of the Uranyl Coordination Polymer with Multifunction Stimulus Response: Fluorescent Sensors for Halide Ions and Photochromism.

It can provide ideas for the use of uranium elements in the treatment of spent fuel from nuclear wastewater to explore the application potential of uranium element. Thus, it is necessary to research the structure and properties of a novel uranyl coordination polymer (CP) for uranium recovery and reuse. Herein, we designed and prepared a new uranyl CP U-CMNDI based on UO and HCMNDI (HCMNDI = -bis(carboxymethyl)-1,4,5,8-naphthalenediimide).

A UOF based on a cyclotriphosphazene skeleton: fluorescence sensing of different substituted aldehydes and NACs.

A novel uranyl organic framework (U-hdpcp) based on flexible cyclic triphosphazene polycarboxylate ligands was prepared, which possesses the ability to sense aromatic aldehyde solutions (benzaldehyde, salicylaldehyde and 2-bromobenzaldehyde) and nitro compounds (2,4,6-trinitrophenol, 2,4-dinitrophenol and -nitrophenol). A fluorescent thin film based on U-hdpcp@PVA with the ability to sense aldehyde vapors was prepared a spin coating method. The work expands the library of UOF materials based on large-sized carboxylic acid ligands and demonstrates promising applications in the field of fluorescent sensors.

HCR/DNAzyme-triggered cascaded feedback cycle amplification for self-powered dual-photoelectrode detection of femtomolar HPV16.

For high-performance dual-photoelectrode assay, developing a pair of photoactive materials with well-matched band structure and the design of a powerful sensing strategy are highly desirable. Herein, the Zn-TBAPy pyrene-based MOF and BiVO/TiC Schottky junction were employed as photocathode and photoanode to form an efficient dual-photoelectrode system. The integration of the cascaded hybridization chain reaction (HCR)/DNAzyme-assisted feedback amplification with DNA walker-mediated cycle amplification strategy realizes femtomolar HPV16 dual-photoelectrode bioassay.

Effects of Dietary Isoleucine Supplementation on the Production Performance, Health Status and Cecal Microbiota of Arbor Acre Broiler Chickens.

A total of 24,000 healthy 1-day-old Arbor Acres broilers with similar initial weights were used in this study and fed a basal diet supplemented with 0, 400 and 800 mg/kg isoleucine (Ile), denoted CON, ILE400 and ILE800, respectively. Results revealed that the final body weight, average daily weight gain, and eviscerated carcass rate, of broiler chickens in the ILE400 group were significantly higher than in other groups ( < 0.05).

Effects of dietary Bopu powder supplementation on intestinal development and microbiota in broiler chickens.

This study aimed to investigate the effect of dietary supplementation with Bopu powder on intestinal development and bacterial community composition in broiler chickens. A total of 486 1-day-old arbor acres broilers were fed a basal diet (CON group), a basal diet supplemented with 50 mg/kg aureomycin (AB group), or a basal diet supplemented with 40 mg/kg Bopu powder (BP group). The results showed that the BP group had significantly lower serum tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and diamine oxidase concentrations and had significantly higher serum IL-10 concentrations than CON group ( < 0.

Dietary tannic acid supplementation in the diets improves growth performance, immune function and liver health status of broiler chicken.

This experiment was conducted to investigate the effects of tannic acid (TA) on growth performance, immune function, and liver health status in broilers. A total of 288 1-day-old Arbor Acres broiler chickens were randomly divided into two groups in a 42-days study. The two groups were a basal diet (CON group) and a basal diet supplemented with 300 mg/kg tannic acid (TA group).

Stimulus-Responsive Lanthanide MOF Materials Encapsulated with Viologen Derivatives: Characterization, Photophysical Properties and Sensing on Nitrophenols.

Viologens (1,1'-disubstituted 4,4'-bipyridyls) possessing electron-deficient properties and redox activity are a class of suitable chromophores to assemble metal-organic hybrid photochromic materials. Thus, viologen-functionalized metal-organic frameworks (MOFs) have attracted much attention for their photochromic properties; however, the syntheses of lanthanide-viologen hybrid crystalline photochromic materials still face many challenges. For example, the structures and properties of the final products are difficult to predict and are limited by molecular configurations.

Effect of Different Cooking Methods on Nutrients, Antioxidant Activities and Flavors of Three Varieties of .

This work evaluated the effect of different cooking methods (boiling, steaming, microwaving, frying and pressure cooking) on the nutrients, antioxidant activities, volatile and nonvolatile taste-active components of three varieties of (808, 0912 and LM) from Guizhou Province. The results showed that LM had the most polysaccharides, 0912 had the most minerals, but LM, 808 and 0912 had low amounts of polyphenols, dietary fiber and proteins, respectively. The dietary fiber and protein were decreased by 4.

Cage Bismuth Metal-Organic Framework Materials Based on a Flexible Triazine-Polycarboxylic Acid: Subgram Synthesis, Application for Sensing, and White Light Tuning.

Bismuth-based metal-organic frameworks (MOFs) have always attracted the attention of many researchers. Here, we first report a crystalline Bi-MOF (Bi-TDPAT) based on a flexible triazine-polycarboxylic linker 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (HTDPAT) and bismuth nitrate; its crystallite quality is adequately good and the diffraction data can be collected directly by single crystal X-ray diffraction rather than 3D electron diffraction. The structure of Bi-TDPAT belongs to a novel topology type .

Switchable Multiplex Photoelectrochemical Immunoassay of Aβ and Aβ Based on a pH-Responsive i-Motif Probe and Pyrene-Based MOF Photocathode.

In accurately diagnosing Alzheimer's disease (AD) and distinguishing AD from other dementia, the concentration ratio of amyloid-beta 42 (Aβ) to Aβ is more reliable than the concentration of Aβ alone. For the multiplex PEC assay, generating an independent photocurrent of multiple targets on a single interface is a great challenge. Herein, an i-motif-based switchable sensing approach is proposed to construct a pH-regulated multiplex PEC immunosensor for Aβ and Aβ by using Bi-TBAPy as an efficient photoactive cathode material.

Does Twisted π-Conjugation Framework Always Induce Efficient Intersystem Crossing? A Case Study with Benzo[]- and []Phenanthrene-Fused BODIPY Derivatives and Identification of a Dark State.

The photophysical properties, especially the intersystem crossing (ISC) of two heavy-atom-free BODIPY derivatives with twisted π-conjugated frameworks (benzo[]-fused BODIPY, ; and []phenanthrene-fused BODIPY, ), are studied with steady-state and time-resolved optical and electron paramagnetic resonance (TREPR) spectroscopic methods as well as with ADC(2) theoretical investigations. Interestingly, has a planar π-conjugation framework, but it displays UV-vis absorption (ε = 3.8 × 10 M cm at 569 nm) and fluorescence (Φ < 0.

Integrated Photoresponsive Alkaline Earth Metal Coordination Networks: Synthesis, Topology, Photochromism and Photoluminescence Investigation.

Photoresponsive materials are a key part of the age of smart technology that have potential in a broad range of applications. Coordination networks (CNs) are widely used due to their designability and stability. In this work, three novel alkaline earth metal coordination networks (AEM-CNs): [Mg(CMNDI)(H O) ], [Ca(CMNDI)(H O) ]⋅H O, and [Sr(CMNDI)(H O)(DMF)] with fsl, cds, and scn topology nets were synthetized via N,N'-bis(carboxymethyl)-1,4,5,8-naphthalenediimide (H CMNDI); the scn net is not found in the Reticular Chemistry Structure Resource or ToposPro.

Polyiodine-Modified 1,3,5-Benzenetricarboxylic Acid Framework Zn(II)/Cd(II) Complexes as Highly Selective Fluorescence Sensors for Thiamine Hydrochloride, NACs, and Fe/Zn.

Four new complexes, [Zn(TIBTC)(DMA)]·[NH(CH)] (), [Cd(TIBTC)(HO)]·[NH(CH)]·DMA (), [Cd(TIBTC)(2,2'-bipy)(HCOO)] (), and [Cd(DIBTC)(2,2'-bipy)(HCOO)] () (HTIBTC = 2,4,6-triiodo-1,3,5-benzenetricarboxylic acid, HDIBTC = 2,4-diiodo-1,3,5-benzenetricarboxylic acid, 2,2'-bipy = 2,2'-bipyridine, and DMA = dimethylacetamide), were successfully synthesized and characterized by elemental analysis, powder X-ray diffraction, infrared spectroscopy, ultraviolet-visible spectroscopy, and thermogravimetric analysis. Complexes and are three-dimensional supramolecular network structures, while complex has a two-dimensional network structure. We preliminarily studied the fluorescence properties of the complexes and found that complexes can detect thiamine hydrochloride, NACs, and Fe/Zn with high sensitivity and selectivity.

Clinical Effects of CpG-Based Treatment on the Efficacy of Hepatocellular Carcinoma by Skewing Polarization Toward M1 Macrophage from M2.

Objective: This study aims to explore the clinical efficacy of CpG-based therapy for treating hepatocellular carcinoma (HCC) by skewing polarization toward M1 macrophage from M2.

Methods: Pulmonary metastasis rate, overall survival time, and remission rate of 10 patients with HCC treated with transcatheter arterial chemoembolization (TACE) combined with CpG therapy and 10 age-, gender-, and TNM-matched patients treated with TACE (control group) were compared.

Results: No pulmonary metastasis rate was 70% in the combined treatment group and 40% in the control group, respectively; and the differences between the two groups were statistically significant (p < 0.

Reversing the polarization of tumor-associated macrophages inhibits tumor metastasis.

Objective: The M2 phenotype is dominant in tumor associated macrophages (TAM), and plays a key role in promoting tumor growth, invasion and metastasis. Converting TAM polarization from M2 to M1 may contribute to eliciting anti-tumor-specific immune responses and inhibiting tumor metastasis. In this study, the effect of reversing the polarization of TAM on tumor metastasis was investigated.

Specific cellular immune response elicited by the necrotic tumor cell-stimulated macrophages.

Objective: To determine whether the necrotic tumor cell-stimulated macrophages (NTCSM) could elicit specific immune response.

Methods: Mice were immunized with the necrotic H22 tumor cell lysate-stimulated macrophages and the specific immune responses against the same tumor challenge were examined. The morphologic characteristics were observed with the transmission electron microscope and scanning electron microscopy.

Potential Neurogenesis of Human Adipose-Derived Stem Cells on Electrospun Catalpol-Loaded Composite Nanofibrous Scaffolds.

Catalpol, a natural active ingredient extracted from the traditional Chinese medicine, was verified exhibiting beneficial effects on neural differentiation compared with commonly used chemical inducers by our previous studies. The aim of this study was to evaluate the effects of catalpol-loaded scaffold on guiding neuronal differentiation of human adipose tissue-derived stem cells (hASCs). Fabrication technique of catalpol loading into the electrospun poly(lactic-co-glycolic acid)/multi-walled carbon nanotubes/silk fibroin nanofibrous scaffolds was successfully established.

Synthesis, crystal structure, photoluminescence property and photoelectronic behavior of two uranyl-organic frameworks constructed from 1, 2, 4, 5-benzenetetracarboxylic acid as ligand.

By using 1, 2, 4, 5-benzenetetracarboxylic acid as organic ligands, two uranyl coordination complexes, (UO2)2(bta)(DMA)2 (1) and [(UO2)2(bta)(μ3-OH2)]·2[HN(CH3)2]·H2O (2) (H4bta=1, 2, 4, 5-benzenetetracarboxylic acid, DMA=N,N-Dimethylacetamide) were synthesized. The X-ray single crystal analysis revealed that complex 1 exhibits a 3-demensional framework, while complex 2 exhibits a 2-demensional framework. In order to furthermore characterize the two complexes and extend their functional properties, spectroscopies of IR, UV-vis, photoluminescence and surface photovoltage were also studied primarily.

Application of multiple parallel perfused microbioreactors: Synthesis, characterization and cytotoxicity testing of the novel rare earth complexes with indole acid as a ligand.

Three novel complexes, [La(phen)2(IAA)2]·NO3 (1), [Sm(phen)2(IAA)2]·NO3 (2) and [Sm(IBA)3(phen)]·phen·HNO3·H2O (3) (phen: 1,10-phenanthroline, IAA: indole-3-acetic acid, IBA: indole-3-butyric acid), were synthesized and characterized with spectroscopy (infrared and UV-visible), X-ray crystal diffraction and elemental analysis. Structural analysis revealed that each lanthanide atom in complexes 1-3 held a distorted tricapped trigonal prism geometry in a nine-coordinate mode. There were two types of coordination modes of the IAA ligand in complexes 1 and 2: a μ2-η(1):η(2) bridging mode linking two lanthanide atoms and a μ2-η(1):η(1) double monodentate bridging mode.

Synthesis, structures and properties of the catalytic bromination reaction of a series of novel scorperate oxidovanadium complexes with the potential detection of hydrogen peroxide in water.

A series of scorpionate oxovanadium (IV) complexes: [VO(Tp(4I))(pz)(SCN)]·1/2CH2Cl2 (1), [VO(Tp)(pzTp)]·2H2O (2), [VO(Bp)(Tp(4I))] (3) and [VO(C5H7O2)(Tp(4I))]·CH3OH (4) (Bp: [H2B(pz)(2-)], Tp: [HB(pz)(3-)], Tp(4I): [HB(4I-pz)(3-)], pzTp: [B(pz)(4-)]) have been synthesized and characterized by elemental analysis, IR spectra, UV-Vis spectroscopy, powder X-ray diffraction, single-crystal X-ray diffraction and thermal gravimetric analysis (TG). Structural analysis shows that the coordination environment of vanadium atom is N5O, to form a distorted octahedron geometry. In addition, the catalytic activities of the bromination reactions for complexes 1 and 2 in phosphate buffer with phenol red as a trap were evaluated primary by UV/Vis spectroscopy, and a practical application of H2O2 detection was firstly observed in the catalytic reaction system.

1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.

The inclusion complex between beta-CD and 1-hexadecanol is synthesized and identified via (1)H NMR spectrum. The possible conformation of the inclusion complex is figured out. Via MM2 calculations, the possibility of complexation is verified.