Cobalt nanoparticles decorated hollow N-doped carbon nanospindles enable high-performance lithium-oxygen batteries.

Despite the ultrahigh theoretical energy density and cost-effectiveness, aprotic lithium-oxygen (Li-O) batteries suffer from slow oxygen redox kinetics at cathodes and large voltage hysteresis. Here, we well-design ultrafine Co nanoparticles supported by N-doped mesoporous hollow carbon nanospindles (Co@HCNs) to serve as efficient electrocatalysts for Li-O battery. Benefiting from strong metal-support interactions, the obtained Co@HCNs manifest high affinity for the LiO intermediate, promoting formation of ultrathin nanosheet-like LiO with low-impedance contact interface on the Co@HCNs cathode surface, which facilitates the reversible decomposition upon charging.

Atomic Ruthenium-Riveted Metal-Organic Framework with Tunable d-Band Modulates Oxygen Redox for Lithium-Oxygen Batteries.

Non-aqueous Li-O batteries have aroused considerable attention because of their ultrahigh theoretical energy density, but they are severely hindered by slow cathode reaction kinetics and large overvoltages, which are closely associated with the discharge product of LiO. Herein, hexagonal conductive metal-organic framework nanowire arrays of nickel-hexaiminotriphenylene (Ni-HTP) with quadrilateral Ni-N units are synthesized to incorporate Ru atoms into its skeleton for NiRu-HTP. The atomically dispersed Ru-N sites manifest strong adsorption for the LiO intermediate owing to its tunable d-band center, leading to its high local concentration around NiRu-HTP.

Quenching singlet oxygen via intersystem crossing for a stable Li-O battery.

Aprotic Li-O batteries are a promising energy storage technology, however severe side reactions during cycles lead to their poor rechargeability. Herein, highly reactive singlet oxygen (O) is revealed to generate in both the discharging and charging processes and is deterimental to battery stability. Electron-rich triphenylamine (TPA) is demonstrated as an effective quencher in the electrolyte to mitigate O and its associated parasitic reactions, which has the tertiary amine and phenyl groups to manifest excellent electrochemical stability and chemical reversibility.

Internal Electric Field and Interfacial Bonding Engineered Step-Scheme Junction for a Visible-Light-Involved Lithium-Oxygen Battery.

Li-O batteries have aroused considerable interest in recent years, however they are hindered by high kinetic barriers and large overvoltages at cathodes. Herein, a step-scheme (S-scheme) junction with hematite on carbon nitride (Fe O /C N ) is designed as a bifunctional catalyst to facilitate oxygen redox for a visible-light-involved Li-O battery. The internal electric field and interfacial Fe-N bonding in the heterojunction boost the separation and directional migration of photo-carriers to establish spatially isolated redox centers, at which the photoelectrons on C N and holes on Fe O remarkably accelerate the discharge and charge kinetics.

Spin-State Manipulation of Two-Dimensional Metal-Organic Framework with Enhanced Metal-Oxygen Covalency for Lithium-Oxygen Batteries.

Aprotic Li-O batteries have attracted extensive attention in the past decade owing to their high theoretical energy density; however, they are obstructed by the sluggish reaction kinetics at the cathode and large voltage hysteresis. We regulate the spin state of partial Ni metal centers (t e ) of conductive nickel catecholate framework (Ni -NCF) nanowire arrays to high-valence Ni (t e ) for Ni -NCF. The spin-state modulation enables enhanced nickel-oxygen covalency in Ni -NCF, which facilitates electron exchange between the Ni sites and oxygen adsorbates and accelerates the oxygen redox kinetics.

Surface plasmon mediates the visible light-responsive lithium-oxygen battery with Au nanoparticles on defective carbon nitride.

Aprotic lithium-oxygen (Li-O) batteries have gained extensive interest in the past decade, but are plagued by slow reaction kinetics and induced large-voltage hysteresis. Herein, we use a plasmonic heterojunction of Au nanoparticle (NP)-decorated CN with nitrogen vacancies (Au/N-CN) as a bifunctional catalyst to promote oxygen cathode reactions of the visible light-responsive Li-O battery. The nitrogen vacancies on N-CN can adsorb and activate O molecules, which are subsequently converted to LiO as the discharge product by photogenerated hot electrons from plasmonic Au NPs.

Semiconducting Metal-Organic Polymer Nanosheets for a Photoinvolved Li-O Battery under Visible Light.

Li-O batteries are considered the ultimate energy storage technology for their potential to store large amounts of electrical energy in a cost-effective and simple platform. Large overpotentials for the formation and oxidation of LiO during discharging and charging have thus far confined this technology to a scientific curiosity. Herein, we consider the role of catalytic intervention in the reversibility of the cathode reactions and find that semiconducting metal-organic polymer nanosheets composed of cobalt-tetramino-benzoquinone (Co-TABQ) function as a bifunctional catalyst that facilitates the kinetics of the cathode reactions under visible light.

Deciphering Key Pharmacological Pathways of Qingdai Acting on Chronic Myeloid Leukemia Using a Network Pharmacology-Based Strategy.

Qingdai, a traditional Chinese medicine (TCM) used for the treatment of chronic myeloid leukemia (CML) with good efficacy, has been used in China for decades. However, due to the complexity of traditional Chinese medicinal compounds, the pharmacological mechanism of Qingdai needs further research. In this study, we investigated the pharmacological mechanisms of Qingdai in the treatment of CML using network pharmacology approaches.

Effect of first-line endocrine therapy in patients with hormone-sensitive advanced breast cancer: a network meta-analysis.

Background: Endocrine therapy is the cornerstone treatment for patients with hormone receptor-positive advanced breast cancer. We aimed to assess the effectiveness of various first-line endocrine monotherapies or combinations to determine the optimal sequence in a network meta-analysis.

Materials And Methods: We searched PubMed, EMBASE, and the Cochrane Library for randomized controlled trials (RCTs) from inception up to November 21, 2017.

Clinicopathological characteristics and prognostic value of the cancer stem cell marker ALDH1 in ovarian cancer: a meta-analysis.

Background: The clinicopathological and prognostic values of the cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) in ovarian cancer (OC) remain unknown. The aim of our meta-analysis was to evaluate ALDH1's association with clinicopathological characteristics and its prognostic significance in patients with OC.

Materials And Methods: PubMed, Embase, and China Biology Medicine were systematically searched for eligible studies (up to October 2017).

Construction of a protein-protein interaction network for chronic myelocytic leukemia and pathway prediction of molecular complexes.

Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known.

Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network.