Collagen-based hydrogels induce hyaline cartilage regeneration by immunomodulation and homeostasis maintenance.

Type I collagen (Col I) and hyaluronic acid (HA), derived from the extracellular matrix (ECM), have found widespread application in cartilage tissue engineering. Nevertheless, the potential of cell-free collagen-based scaffolds to induce in situ hyaline cartilage regeneration and the related mechanisms remain undisclosed. Here, we chose Col I and HA to construct Col I hydrogel and Col I-HA composite hydrogel with similar mechanical properties, denoted as Col and ColHA, respectively.

A Data Augmentation Method for Motor Imagery EEG Signals Based on DCGAN-GP Network.

Motor imagery electroencephalography (EEG) signals have garnered attention in brain-computer interface (BCI) research due to their potential in promoting motor rehabilitation and control. However, the limited availability of labeled data poses challenges for training robust classifiers. In this study, we propose a novel data augmentation method utilizing an improved Deep Convolutional Generative Adversarial Network with Gradient Penalty (DCGAN-GP) to address this issue.

Electroencephalographic Signal Data Augmentation Based on Improved Generative Adversarial Network.

EEG signals combined with deep learning play an important role in the study of human-computer interaction. However, the limited dataset makes it challenging to study EEG signals using deep learning methods. Inspired by the GAN network in image generation, this paper presents an improved generative adversarial network model L-C-WGAN-GP to generate artificial EEG data to augment training sets and improve the application of BCI in various fields.

Exploring the effects of the dietary fiber compound mediated by a longevity dietary pattern on antioxidation, characteristic bacterial genera, and metabolites based on fecal metabolomics.

Background: Age-related dysbiosis of the microbiota has been linked to various negative health outcomes. This study aims to investigate the effects of a newly discovered dietary fiber compound (DFC) on aging, intestinal microbiota, and related metabolic processes. The DFC was identified through in vitro fermentation screening experiments, and its dosage and composition were determined based on a longevity dietary pattern.

Difunctional Ag nanoparticles with high lithiophilic and conductive decorate on core-shell SiO nanospheres for dendrite-free lithium metal anodes.

Lithium metal is an attractive and promising anode material due to its high energy density and low working potential. However, the uncontrolled growth of lithium dendrites during repeated plating and stripping processes hinders the practical application of lithium metal batteries, leading to low Coulombic efficiency, poor lifespan, and safety concerns. In this study, we synthesized highly lithiophilic and conductive Ag nanoparticles decorated on SiO nanospheres to construct an optimized lithium host for promoting uniform Li deposition.

EEG Emotion Recognition by Fusion of Multi-Scale Features.

Electroencephalogram (EEG) signals exhibit low amplitude, complex background noise, randomness, and significant inter-individual differences, which pose challenges in extracting sufficient features and can lead to information loss during the mapping process from low-dimensional feature matrices to high-dimensional ones in emotion recognition algorithms. In this paper, we propose a Multi-scale Deformable Convolutional Interacting Attention Network based on Residual Network (MDCNAResnet) for EEG-based emotion recognition. Firstly, we extract differential entropy features from different channels of EEG signals and construct a three-dimensional feature matrix based on the relative positions of electrode channels.

Uplink Assisted MIMO Channel Feedback Method Based on Deep Learning.

In order to solve the problem wherein too many base station antennas are deployed in a massive multiple-input-multiple-output system, resulting in high overhead for downlink channel state information feedback, this paper proposes an uplink-assisted channel feedback method based on deep learning. The method applies the reciprocity of the uplink and downlink, uses uplink channel state information in the base station to help users give feedback on unknown downlink information, and compresses and restores the channel state information. First, an encoder-decoder structure is established.

Wireless Channel Prediction of GRU Based on Experience Replay and Snake Optimizer.

Aiming at the problem of poor prediction accuracy of Channel State Information (CSI) caused by fast time-varying channels in wireless communication systems, this paper proposes a gated recurrent network based on experience replay and Snake Optimizer for real-time prediction in real-world non-stationary channels. Firstly, a two-channel prediction model is constructed by gated recurrent unit, which adapts to the real and imaginary parts of CSI. Secondly, we use the Snake Optimizer to find the optimal learning rate and the number of hidden layer elements to build the model.

Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation.

Manganese (Mn) is an essential nutrient, but is toxic in excess. Whole-body Mn levels are regulated in part by the metal-ion influx transporter SLC39A8, which plays an essential role in the liver by reclaiming Mn from bile. Physiological roles of SLC39A8 in Mn homeostasis in other tissues, however, remain largely unknown.

Functional injectable hydrogel with spatiotemporal sequential release for recruitment of endogenous stem cells and cartilage regeneration.

Articular cartilage is refractory to self-healing due to the absence of vascular, nervous, and lymphatic systems, and its repair remains a clinical challenge. Tissue regeneration through recruitment of stem cells cell-free scaffolds is a promising alternative strategy. Herein, a kind of functional injectable hydrogel system (Col-Apt@KGN MPs), which is a collagen-based and microsphere-embedded cell-free scaffold, was designed to achieve spatiotemporal regulation of endogenous mesenchymal stem cells (MSCs) recruitment and their chondrogenic differentiation by respective release of aptamer 19S (Apt19S) and kartogenin (KGN).

A Model-Driven Channel Estimation Method for Millimeter-Wave Massive MIMO Systems.

Aiming at the problem of low estimation accuracy under a low signal-to-noise ratio due to the failure to consider the "beam squint" effect in millimeter-wave broadband systems, this paper proposes a model-driven channel estimation method for millimeter-wave massive MIMO broadband systems. This method considers the "beam squint" effect and applies the iterative shrinkage threshold algorithm to the deep iterative network. First, the millimeter-wave channel matrix is transformed into a transform domain with sparse features through training data learning to obtain a sparse matrix.

Hydrogen-rich water treatment increased several phytohormones and prolonged the shelf life in postharvest okras.

Hydrogen-rich water (HRW) treatment has been reported to delay the softening and senescence of postharvest okras, but its regulatory mechanism remains unclear. In this paper, we investigated the effects of HRW treatment on the metabolism of several phytohormones in postharvest okras, which act as regulatory molecules in fruit ripening and senescence processes. The results showed that HRW treatment delayed okra senescence and maintained fruit quality during storage.

γ-Aminobutyric acid treatment induced chilling tolerance in postharvest peach fruit by upregulating ascorbic acid and glutathione contents at the molecular level.

Peach fruit was treated with 5 mM γ-aminobutyric acid (GABA) to further investigate the mechanism by which GABA induced chilling tolerance. Here, we found that GABA not only inhibited the occurrence of chilling injury in peach fruit during cold storage but also maintained fruit quality. Most of the ascorbic acid (AsA) and glutathione (GSH) biosynthetic genes were up-regulated by GABA treatment, and their levels were increased accordingly, thus reducing chilling damage in treated peaches.

Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.

Alzheimer's disease (AD) is a complex neurodegenerative disease that is prevalent around the world. Both Apelin-13 and proliferator-activated receptor-γ (PPARγ)/PPARγ co-activator 1α (PGC-1α) are regarded as candidate targets for treating AD. The investigation examined whether Apelin-13 exerts neuroprotective effects via PGC-1α/PPARγ signaling.

The synergistic regulation of chondrogenesis by collagen-based hydrogels and cell co-culture.

The suitable seeding cells and scaffolds are very important for tissue engineering to create functional cartilage. Although the physicochemical properties of scaffold and co-culture system of mesenchymal stem cells (MSCs) and chondrocytes could affect functional properties of engineered cartilage tissues respectively, the combined effects of them on chondrogenesis is currently unknown. Herein, methacrylated collagen (CMA30 and CMA80) hydrogels with different degradation rate and stiffness were prepared.

γ-Aminobutyric acid treatment induced chilling tolerance in postharvest kiwifruit (Actinidia chinensis cv. Hongyang) via regulating ascorbic acid metabolism.

The effect of γ-Aminobutyric acid (GABA) treatment on ascorbic acid (AsA) metabolism and chilling injury in postharvest kiwifruit was studied. The results revealed that kiwifruit treated with GABA displayed higher chilling tolerance and better quality maintenance as compared to the controls. Higher AsA was observed in GABA-treated fruit which was beneficial to cell membrane protection and damage alleviation against chilling mediated oxidative stress.

A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection.

ZIP8 (SLC39A8) is a transmembrane divalent metal ion importer that is most highly expressed in the lung and is inducible by inflammatory stimuli. In addition to zinc and manganese, ZIP8 can transport iron, but its specific roles in iron regulation during homeostatic and pathologic processes remain poorly understood. Using a novel global inducible ZIP8 knockout (KO) mouse, we analyzed the role of ZIP8 in steady-state iron homeostasis and during inflammation and infection.

Clinical Study on the Application of Preserved Urethral Mucosa at the Prostatic Apex in Transurethral Plasmakinetic Resection of the Prostate.

Objective: To explore the differences in the clinical efficacy, complications, and safety of transurethral plasmakinetic resection of the prostate (PKRP) by the conventional approach versus the approach preserving the urethral mucosa at the prostatic apex in the treatment of benign prostatic hyperplasia (BPH).

Methods: A total of 90 patients with PKRP admitted to the First Hospital of Qinhuangdao from December 2018 to March 2021 were selected and divided into a control group (conventional PKRP,  = 45) and an observation group (PKRP with preserved urethral mucosa at the prostatic apex,  = 45). The clinical efficacy, safety, and sexual function of the groups were evaluated using the patients' International Prostate Symptom Score (IPSS), quality of life (QoL), prostate volume, maximum flow rate (Qmax), post-void residual (PVR), blood loss, surgical resection efficiency, and surgical complication data.

Membrane lipid metabolism influences chilling injury during cold storage of peach fruit.

Peach fruit is prone to chilling injury (CI) during long-term low temperature (LT) storage, and develops protective mechanisms against LT stress. This study revealed that 4 °C storage induced the occurrence of CI in peach fruit by promoting the expression of membrane lipid metabolism genes and phosphatidic acid (PA) accumulation, and stimulated a protective mechanism for peach fruit against LT by increasing diacylglycerol (DAG), triacylglycerol (TAG) and several phosphatidylcholine (PC) components in the later storage stage. In contrast, 0 °C delayed the occurrence of CI in peach fruit by delaying the degradation of phospholipids, upregulation of fatty acid desaturase (FAD) and the process of fatty acid unsaturation, and maintaining higher levels of PC and PE.