A Comparison Between Ripening Under a Constant Volume and Ripening Under a Constant Surface Area.

The classic Lifshitz-Slyozov-Wagner (LSW) theory of ripening assumes a constant volume. In comparison, we present here a model of ripening assuming a constant surface area, which has occurred in the microstructure changes in intermetallic compounds in micro-bump for 3D integrated-circuit (IC) technology in consumer electronic products. However, to keep a constant surface area requires the growth of the volume.

Continuous Provisioning Increases Breeding Success of Black-and-White Snub-Nosed Monkeys (Rhinopithecus bieti) in the Baima Snow Mountain Nature Reserve, Yunnan, China.

The high energy demands of primates during pregnancy and lactation often limit their breeding success due to the availability of food resources. Until now, few studies have focused on the effects of continuous provisioning on primate reproduction. To assess the impact of continuous provisioning on breeding success, we collected data on female reproductive status (primiparous or multiparous), maternal age of births, births, deaths, and sex of infants in a free-ranging semi-provisioned band (FSB) of Rhinopithecus bieti in China from 2010 to 2023.

Alkaline Phosphatase-Regulated DNAzyme Cleavage Coupled with CRISPR/Cas12a for Quantitative Detection of Deoxynivalenol in Agricultural Crops.

Sensitive and simplified detection of a mycotoxin such as deoxynivalenol (DON) is crucial for food safety. In recent years, the CRISPR/Cas technology has demonstrated significant potential in detecting non-nucleic acids. Herein, we present a triple enzyme-assisted fluorescence immunoassay (TEFIA) that integrates alkaline phosphatase (ALP)-regulated DNAzyme cleavage with the CRISPR/Cas12a assay for the accurate detection of mycotoxin.

Integrated multi-approaches reveal unique metabolic mechanisms of Vestimentifera to adapt to deep sea.

Background: Vestimentiferan tubeworms are deep-sea colonizers, in which chemoautotrophic symbiosis was first observed. These animals are gutless and depend on endosymbiotic bacteria for organic compound synthesis and nutrition supply. Taxonomically, vestimentiferans belong to Siboglinidae and Annelida.

Aspartate restrains thermogenesis by inhibiting the AMPK pathway in adipose tissues.

Increasing evidence suggests that brown adipose tissue (BAT) plays an important role in obesity and related diseases. Great progress has been made in identifying positive regulators that activate adipocyte thermogenesis, but negative regulatory signaling of thermogenesis remains poorly understood. Here, we evaluated the potential effects of aspartate on the BAT function.

An advanced TSMK-FVC approach combined with Landsat 5/8 imagery for assessing the long-term effects of terrain and climate on vegetation growth.

Introduction: As an exceptional geographical entity, the vegetation of the Qinghai-Tibetan Plateau (QTP) exhibits high sensitivity to climate change. The Baima Snow Mountain National Nature Reserve (BNNR) is located in the south-eastern sector of the QTP, serving as a transition area from sub-tropical evergreen broadleaf forest to high-mountain vegetation. However, there has been limited exploration into predicting the temporal and spatial variability of vegetation cover using anti-interference methods to address outliers in long-term historical data.

High-Quality Spherical Silver Alloy Powder for Laser Powder Bed Fusion Using Plasma Rotating Electrode Process.

The plasma rotating electrode process (PREP) is an ideal method for the preparation of metal powders such as nickel-based, titanium-based, and iron-based alloys due to its low material loss and good degree of sphericity. However, the preparation of silver alloy powder by PREP remains challenging. The low hardness of the mould casting silver alloy leads to the bending of the electrode rod when subjected to high-speed rotation during PREP.

Nitrogen and sulfur cycling driven by Campylobacterota in the sediment-water interface of deep-sea cold seep: a case in the South China Sea.

Chemoautotrophs within Campylobacterota, especially and , are abundant in the seawater-sediment interface of the Formosa cold seep in the South China Sea. However, the activity and function of Campylobacterota are unknown. In this study, the geochemical role of Campylobacterota in the Formosa cold seep was investigated with multiple means.

Is there a correlation between sensory impairments and social isolation in middle-aged and older Chinese population? Cross-sectional and longitudinal evidence from a nationally representative survey.

Purpose: The aim of this study is to investigate the cross-sectional and longitudinal associations between sensory impairments (SIs) including single vision impairment (SVI), single hearing impairment (SHI), and dual sensory impairments (DSI) with social isolation in the middle-aged and older Chinese population.

Methods: Data were obtained from the China Health and Retirement Longitudinal Survey (CHARLS). In total, 11,674 Chinese older adults aged over 45 were included at baseline 2011, and 6,859 participants who accomplished all four interviews from 2011 to 2018 were adapted for longitudinal analyses.

Do Sensory Impairments Portend Cognitive Decline in Older Chinese Adults? Longitudinal Evidence from a Nationally Representative Survey, 2011-2018.

Previous studies on longitudinal sensory-cognition association are limited and have yielded inconsistent conclusions in western and developed countries. The present study obtained data from the China Health and Retirement Longitudinal Survey (CHARLS, 2011−2018) and aimed to investigate the longitudinal effects of sensory impairments including single vision impairment (SVI), single hearing impairment (SHI), and dual sensory impairment (DSI) on cognitive decline in middle-aged and older Chinese population. In total, 11,122 participants accomplished all 4 interviews over 8 years and were included.

Adherence to Annual Fundus Exams among Chinese Population with Diagnosed Diabetes.

Adherence to annual fundus examinations in the Chinese population with diabetes and its correlates have not been investigated. The present study obtained data for the first nationally representative survey in China, China Health and Retirement Longitudinal Survey (CHARLS), which collected a wide range of data every 2 years, including demographic, socioeconomic, medical and lifestyle-related information. The adherence rates to annual fundus exams across four waves (2011−2018) were assessed.

Fabrication of Titanium and Copper-Coated Diamond/Copper Composites via Selective Laser Melting.

The poor wettability and weak interfacial bonding of diamond/copper composites are due to the incompatibility between diamond and copper which are inorganic nonmetallic and metallic material, respectively, which limit their further application in next-generation heat management materials. Coating copper and titanium on the diamond particle surface could effectively modify and improve the wettability of the diamond/copper interface via electroless plating and evaporation methods, respectively. Here, these dense and complex composites were successfully three-dimensionally printed via selective laser melting.

Network Pharmacology with Experimental Investigation of the Mechanisms of against Prostate Cancer with Additional Herbzymatic Activity.

A combination therapy of (RP) with goji () has earned a long history in the prescriptions to promote male health. However, the mechanisms at both molecular and nanoscale quantum levels are unclear. Here, we found that processed RP extract induces apoptosis and cell cycle arrest in cancer cells, thereby inhibiting prostate cancer cell proliferation enhanced by processed goji extract associated with an augment of the nanoscale herbzyme of phosphatase.

A carbon dot-based Co-nanozyme with alkaline phosphatase - mechanism and application.

Elevated levels of alkaline phosphatase (ALP) are associated with bone metastasis, liver cancer, prostate cancer, breast cancer, and many other diseases or stem cell marker. It is therefore of great significance to quantitatively detect the ALP levels by a rapid, highly sensitive, and easy-to-use strip paper test. In the present work, we discovered an enhancement of ALP activity upon the addition of cauliflower-derived carbon dots (CFCDs), which can be applied as a sensor for ALP.

Network pharmacology and experimental investigation of extract targeted kinase with herbzyme activity for potent drug delivery.

(Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated RP extract combination with kinase inhibitors in anti-cell growth and blockade in pathways targeting kinases. Experimental investigation and network pharmacology analysis were applied to test the potent kinase-mediated signaling.

sp. nov., isolated from deep sea sediment of the Mariana Trench.

A Gram-stain-negative, light pink-coloured, rod-shaped, flagellated and facultative anaerobic bacterial strain, designated MT2928, was isolated from deep-sea sediment collected from the Mariana Trench. Growth of strain MT2928 occurred optimally at 28 °C, pH 8.0-9.

Bacteria and Archaea Synergistically Convert Glycine Betaine to Biogenic Methane in the Formosa Cold Seep of the South China Sea.

Cold seeps are globally widespread seafloor ecosystems that feature abundant methane production and flourishing chemotrophic benthic communities. Chemical evidence indicates that cold seep methane is largely biogenic; however, the primary methane-producing organisms and associated pathways involved in methanogenesis remain elusive. This work detected methane production when glycine betaine (GBT) or trimethylamine (TMA) was added to the sediment microcosms of the Formosa cold seep, South China Sea.

from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger.

Recently, traditional Chinese medicine-based treatment has succeeded in fighting coronavirus disease 2019 (COVID-19), and (Huangjing) has been one of the recommended components. Its processed products play antidiabetic, antiviral, antitumor, antioxidation, antifatigue, antiaging, and immune enhancement roles. The climate in Mount Tai is mild, and the dense forest is suitable for the growth of which has gradually evolved into a unique specie.

sp. nov., isolated from the deep-sea cold seep sediment of South China Sea.

In this study, we report a Gram-stain-negative, rod-shaped, non-pigmented, motile and aerobic bacterium named strain MTZ26, which was isolated from deep-sea sediment sampled at a cold seep in the South China Sea. Growth of strain MTZ26 occurred at 4-40 °C (optimum, 25-30 °C), pH 6.0-10.

sp. nov., isolated from deep-sea sediment.

A novel bacterial strain, designated SW136, was isolated from a deep-sea sediment sample collected from the South China Sea. Cells were Gram-stain-negative, aerobic, catalase-positive and oxidase-positive. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain SW136 represented a novel member of the genus , forming a distinct cluster with '', and (98.

Description of sp. nov., isolated from deep sea sediment from the Mariana Trench, and emended description of the genus .

In this study, we reported a Gram-stain-negative, orange-coloured, rod-shaped, motile and faculatively anaerobic bacterium named strain PB63, which was isolated from the deep-sea sediment from the Mariana Trench. Growth of PB63 occurred at 10-35 °C (optimum, 28 °C), pH 5.0-8.

Bacillus fonticola sp. nov., isolated from deep sea cold seep sediment.

In this study, we report a novel Gram-positive bacterium, designated as strain CS13, isolated from deep-sea sediment collected in the cold seep area of the South China Sea. Growth of strain CS13 occurred at 16-37 °C (optimum 25-28 °C), pH 7.0-9.

Generation of particle assemblies mimicking enzymatic activity by processing of herbal food: the case of rhizoma polygonati and other natural ingredients in traditional Chinese medicine.

Processed herbs have been widely used in eastern and western medicine; however, the mechanism of their medicinal effects has not yet been revealed. It is commonly believed that a central role is played by chemically active molecules produced by the herbs' metabolism. In this work, processed rhizoma polygonati (RP) and other herbal foods are shown to exhibit intrinsic phosphatase-like (PL) activity bounded with the formation of nano-size flower-shaped assembly.