Advances in Organosulfur-Based Polymers for Drug Delivery Systems.

Organosulfur-based polymers have unique properties that make them useful for targeted and managed drug delivery, which can improve therapy while reducing side effects. This work aims to provide a brief review of the synthesis strategies, characterization techniques, and packages of organosulfur-based polymers in drug delivery. More importantly, this work discusses the characterization, biocompatibility, controlled release, nanotechnology, and targeted therapeutic aspects of these important structural units.

Comparison of total percutaneous in situ microneedle puncture and chimney technique for left subclavian artery fenestration in thoracic endovascular aortic repair for type B aortic dissection.

Objective: To compare the outcomes of totally percutaneous in situ microneedle puncture for left subclavian artery (LSA) fenestration (ISMF) and chimney technique in type B aortic dissection (TBAD) during thoracic endovascular aortic repair (TEVAR).

Materials And Methods: Data on patients who underwent either chimney-TEVAR (n = 89) or ISMF-TEVAR (n = 113) from October 2018 to April 2022 were analyzed retrospectively. The primary outcomes were mortality and major complications at 30 days and during follow-up.

Recent Progress in Synthesis and Application of Chiral Organoselenium Compounds.

Chiral organoselenium compounds have shown an important role as intermediates in many areas, such as drug discovery, organic catalysis, and nanomaterials. A lot of different methods have been developed to synthesize chiral compounds which contain selenium, because they have interesting properties and can be used in real life. Over the last few decades, a lot of progress has been made in synthesizing chiral organoselenium compounds.

Advances in Difunctionalization of Olefins with Diorganyl Dichalcogenides.

Organochalcogen molecules have extensive applications in various fields. They serve as pharmaceuticals, ligands, organocatalysts, agrochemicals, and other functional materials. Difunctionalization of olefins, which belong to a class of multicomponent reactions, is a successful technique for introducing two functional moieties in a single-step reaction, both in terms of atom economy and step economy.

Transition Metal-Catalyzed Enantioselective Synthesis of Chiral Five- and Six-Membered Benzo O-heterocycles.

Enantiomerically enriched five- and six-membered benzo oxygen heterocycles are privileged architectures in functional organic molecules. Over the last several years, many effective methods have been established to access these compounds. However, comprehensive documents cover updated methodologies still in highly demand.

Progress in the Enantioselective Synthesis of Sulfur (VI) Compounds.

In recent years, there has been a notable surge in the prominence of enantioenriched sulfur(VI) compounds within the chemical science, particularly in the realm of bioactive molecules. However, the synthesis of these enantioenriched sulfur(VI) compounds has posed significant challenges, necessitating the exploration of diverse synthetic methods. Accordingly, this review aims to provide an in-depth analysis of the latest advancements in the synthesis of sulfoximines, sulfonimidate esters, sulfonimidamides, and sulfonimidoyl halides, with a focus on developments since 1971.

Chromatographic Enantioseparation of Chiral Sulfoximines on Polysaccharide-Based Chiral Stationary Phases.

Chiral sulfoximines have significant roles in pharmaceutical industry and agricultural chemicals. Furthermore, chiral structurally related sulfoximines are used for their wide potential applications in some uncharted territory. However, chromatographic study on these compounds has not been systematically performed.

Recent Advances in the Synthesis of Cyclic Sulfoximines via C-H Bond Activation.

Sulfoximines, a ubiquitous class of structural motifs, are widely present in bioactive molecules and functional materials that have received considerable attention from modern organic chemistry, pharmaceutical industries, and materials science. Sulfoximines have proved to be an effective directing group for C-H functionalization which was widely investigated for the synthesis of cyclic sulfoximines. Within the last decade, great progress has been achieved in the synthesis of cyclic sulfoximines.

Identification of immune-related diagnostic markers in primary Sjögren's syndrome based on bioinformatics analysis.

Background: Primary Sjögren's syndrome (pSS) is a relatively common diffuse connective tissue disease that often invades exocrine glands, such as the lacrimal and salivary glands, and manifests as dry eyes and dry mouth. At present, the molecular mechanism of pSS is not clear. This study was designed to explore the internal mechanism of pSS from the gene level and screen out the immune-related diagnostic markers of pSS.

Percutaneous In Situ Microneedle Puncture Fenestration via the Left Subclavian Artery for branched Thoracic Endovascular Aortic Repair.

This study explored the feasibility of a totally percutaneous approach to perform in situ microneedle puncture fenestration during thoracic endovascular aortic repair (TEVAR) via access from the left subclavian artery (LSA). In total, 23 patients with either thoracic aortic dissection or thoracic aortic aneurysm were treated with in situ LSA fenestration during TEVAR. The procedure was technically successful in all the patients.

Advances of Sulfenate Anions in Catalytic Asymmetric Synthesis of Sulfoxides.

In recent years, sulfenate anions as key intermediates in enantioselective synthesis have attracted considerable attention. Typically, development of novel synthetic methods to generate sulfenate anions allows for the preparation of various enantiopure sulfoxides, which are prevalently used as auxiliaries, ligands, organocatalysts, and biologically active compounds. This review presents the in situ preparation methods and the recent applications of sulfenate anions in catalytic asymmetric synthesis of chiral sulfoxides.

Trends Analysis of Non-Hodgkin Lymphoma at the National, Regional, and Global Level, 1990-2019: Results From the Global Burden of Disease Study 2019.

Non-Hodgkin lymphoma is a common hematologic malignancy. This article aimed to estimate the trends of non-Hodgkin lymphoma (NHL) globally from 1990 to 2019. Data on the NHL burden were explored from the Global Burden of Disease study 2019.

Water-Mediated Intramolecular Cyclization/Oxidation of α-Carbonyl Sulfur Ylides: Synthesis of Corey-Chaykovsky Reagent Type Heterocycles.

A new class of Corey-Chaykovsky reagent type five-membered heterocycles with an oxosulfonium ylide moiety has been synthesized by the water-mediated intramolecular cyclization/oxidation of α-carbonyl sulfur ylides generated from sulfonium salts under mild conditions.

Unusual Deoxidative Coupling Reaction of β-Sulfinyl Esters with Benzylic Trimethylammonium Salts.

A KOH-promoted unusual deoxidative coupling reaction of β-sulfinyl esters with benzylic trimethylammonium salts to produce thioethers is discovered for the first time. If quaternary ammonium salts synthesized from enantiomerically enriched amines are adopted, highly enantiomerically enriched benzyl thioethers (>95-99% ee) with configurations opposite to those of the enantiomerically enriched amines are obtained.

Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019.

Background: Cervical cancer is an important global health problem. In this study we aimed to analyze trends in cervical cancer at the global, regional, and national levels from 1990 to 2019, to inform health service decision-making.

Methods: Data on cervical cancer was extracted from the Global Burden of Disease study, 2019.

Recent Progress on the Synthesis of Chiral Sulfones.

Chiral sulfones extensively exist in drugs, agricultural chemicals, chiral organic intermediates, and functional materials. Their importance causes the rapid development of their synthetic methods in recent years. Many transition metal complex catalysts with chiral ligands and chiral organocatalysts are adopted in synthesis of chiral sulfones.

Recent Advances in Multicomponent Reactions with Organic and Inorganic Sulfur Compounds.

In recent years, multicomponent reactions with inorganic and organic sulfur compounds as one of reactants have achieved a remarkable development. In this review, we summarize recent advances in the multicomponent reactions involving sulfur components, which include elemental sulfur, sodium metabisulfite, sodium hyposulfite, potassium pyrosulfite, DABSO, sodium sulfide, thiocyanate, sulfur dioxide, carbon disulfide and other divalent, tetravalent and hexavalent organosulfur compounds.

Syntheses and Transformations of Sulfoximines.

Sulfoximines are widely used as medicines, agricultural chemicals, chiral precursors, and chiral ligands in asymmetric synthesis, as well as pivotal intermediates for the construction of heterocyclic compounds. NH-sulfoximines may be synthesized from thioethers, sulfoxides, sulfilimines, and sulfinamides. NH-sulfoximines can undergo various transformations, such as arylations, alkylations, vinylations, and alkynylations.

Percutaneous Treatment of Benign Biliary Anastomotic Strictures: Retrievable Covered Self-Expandable Metal Stent with Fixation String Versus Large-Bore Catheters.

Purpose: To retrospectively compare the safety and efficacy of a covered self-expandable metal stent (CSEMS) with a transhepatic fixation string and a large-bore catheter for benign biliary anastomotic stricture after hepatobiliary surgery.

Materials And Methods: From March 2012 to June 2017, 49 patients with benign biliary anastomotic strictures, untreatable with endoscopy, were included. Twenty-three patients (catheter group) were treated with a large-bore catheter (with progressive catheter upsizing to 16-18 Fr), whereas 26 patients (stent group) were treated by CSEMS (10-mm stent) placement.

Transition metal-free coupling reactions of benzylic trimethylammonium salts with di(hetero)aryl disulfides and diselenides.

A new protocol was developed to synthesize (enantioenriched) thioethers and selenoethers from (chiral) benzylic trimethylammonium salts and di(hetero)aryl disulfides or diselenides. These syntheses were promoted by the presence of weak base and did not require the use of any transition metal, and resulted in the target products with good to excellent yields (72-94%). Using quaternary ammonium salts synthesized from enantiomerically enriched amines led to highly enantiopure benzylic thioethers and selenoethers (94-99% ee) with configurations reversed from those of their enantioenriched quaternary ammonium salts.

Recent Advances in Synthesis of Chiral Thioethers.

Chiral thioethers is an important class of organosulfur molecules with extensive applications, especially in the field of medicine and organic synthesis. This review discusses the recent progress of synthesis of enantioenriched chiral thioethers and hopes to be helpful for related research in the future. It is summarized from organosulfur compounds-participating organic reaction types, including nucleophilic substitution, cross coupling, sulfa-Michael addition, sulfenylation, asymmetric allylic reaction, asymmetric Doyle-Kirmse reaction, Pummerer-type rearrangement, Smiles rearrangement, Stevens and Sommelet-Hauser rearrangement.

Interaction of novel Aurora kinase inhibitor MK-0457 with human serum albumin: Insights into the dynamic behavior, binding mechanism, conformation and esterase activity of human serum albumin.

MK-0457, a new pan-aurora kinase inhibitor, is in Phase II clinical development for the treatment of multiple tumor types and hematologic malignancies. The present work explored the dynamic behaviors and interaction mechanism of MK-0457 to human serum albumin (HSA) and the effect on the esterase-like activity and conformation of HSA by computer simulations and experiments. Docking and molecular dynamics trajectory analysis indicated that MK-0457 stably bound to Sudlow's site 2 of HSA by multiple types of interaction forces.

Selection of Stents by Calculation of Arterial Cross-sectional Area in Modified Sandwich Technique for Complex Aortoiliac Arterial Lesions.

Background: We prospectively evaluated the modified sandwich technique for treatment of complex aortoiliac arterial lesions using commercial stent grafts selected according to the arterial cross-sectional area. The primary outcomes were technical feasibility and mid-term follow-up results.

Methods: We prospectively enrolled 13 patients (mean age 63.