AC125611.3 promotes the progression of colon cancer by recruiting DKC1 to stabilize CTNNB1.

Background And Study Aims: Previous studies have suggested that lncRNAs impact cancer progression. The lncRNA AC125611.3 (also referred to as RP11-161H23.

LINC00538 promotes the progression of colon cancer through inhibiting NKD2 expression.

Purpose: The purpose of this study was to explore the possible role and mechanism of LINC00538 in the pathogenesis of colon cancer.

Methods: The expression levels of LINC00538 in 70 pairs of colon cancer tissue samples and adjacent ones were examined by qRT-PCR, and survival analysis of patients was performed according to the result. Meanwhile, colon cancer cell lines were screened.

HSF-1 is involved in attenuating the release of inflammatory cytokines induced by LPS through regulating autophagy.

Autophagy plays a protective role in endotoxemic mice. Heat shock factor 1 (HSF-1) also plays a crucial protective role in endotoxemic mice by decreasing inflammatory cytokines. The purpose of this study was to determine whether HSF-1 is involved in attenuating the release of inflammatory cytokines in lipopolysaccharide (LPS)-stimulated mice and peritoneal macrophages (PMs) through regulating autophagy activity.

[Dynamic pattern of gene expression in rat hearts responding to transient ischemia/reperfusion detected by cDNA microarray and cluster analysis].

Objective: To analyze the pattern of gene expression programs during rat myocardial ischemia/reperfusion at multiple time points.

Methods: Rat model of myocardial ischemia/reperfusion was established by repeating the occlusion and relaxation of left coronary artery. cDNA microarray was used to analyze the pattern of gene expression programs in rat myocardium at 1, 3, 6, 12, 24 hours after reperfusion.