Publications by authors named "Qinglan Li"

Article Synopsis
  • Newly graduated nurses often struggle with professional competence due to insufficient clinical preparation during their studies, highlighting the importance of clinical placements in developing nursing skills.
  • This study aims to analyze differences in professional preparedness levels at various stages of clinical placements, identify patterns in preparedness trajectories, and determine factors influencing these trajectories among nursing students.
  • Utilizing a quantitative approach, the longitudinal study involved 178 senior nursing students who completed surveys over several months, revealing a significant increase in their professional preparedness throughout their clinical placement experience.
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As computer image processing and digital technologies advance, creating an efficient method for classifying sports images is crucial for the rapid retrieval and management of large image datasets. Traditional manual methods for classifying sports images are impractical for large-scale data and often inaccurate when distinguishing similar images. This paper introduces an SE module that adaptively adjusts the weights of input feature mapping channels, and a Res module that excels in deep feature extraction, preventing gradient vanishing, multi-scale processing, and enhancing generalization in image recognition.

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How disruptions to normal cell differentiation link to tumorigenesis remains incompletely understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis, often harbors mutations in epigenetic regulators, but their role in kidney development remains unexplored. Here, we show at single-cell resolution that a Wilms tumor-associated mutation in the histone acetylation reader ENL disrupts kidney differentiation in mice by rewiring the gene regulatory landscape.

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Cervical cancer is one of the most common gynecological malignancies, with the vast majority of which being caused by persistent infection with Human Papillomavirus (HPV) 16 and 18. The current available HPV detection methods are sensitive and genotyped but are restricted by expensive instruments and skilled personnel. The development of an easy-to-use, rapid, and cost-friendly analysis method for HPV is of great need.

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Article Synopsis
  • Vibrio vulnificus, found in contaminated seafood and seawater, can cause serious infections and high death rates, highlighting the need for effective detection methods.
  • A new detection method using a colorimetric immunoassay with CeO@PtRu showed rapid and sensitive results for identifying Vibrio vulnificus, operating effectively within a specific detection range.
  • This biosensor demonstrated excellent specificity and recovery rates, making it a promising tool for sensitive monitoring of Vibrio vulnificus in seafood.
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Cell differentiation during organogenesis relies on precise epigenetic and transcriptional control. Disruptions to this regulation can result in developmental abnormalities and malignancies, yet the underlying mechanisms are not well understood. Wilms tumors, a type of embryonal tumor closely linked to disrupted organogenesis, harbor mutations in epigenetic regulators in 30-50% of cases.

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The forest experience is good for people's physical and mental health. However, few studies on the effects of pure forest based on the duration and way of experience on people's physical and mental recovery. In this study, we took 180 first-year college students as research objects and conducted experiments in and and the control group of grass plot.

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Gain-of-function mutations in the histone acetylation "reader" eleven-nineteen-leukemia (ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive condensate formation and gene activation in cellular systems. However, their role in tumorigenesis remains unclear. Using a conditional knock-in mouse model, we show that mutant ENL perturbs normal hematopoiesis, induces aberrant expansion of myeloid progenitors, and triggers rapid onset of aggressive AML.

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Rationale: Cryptococcosis presenting as endobronchial obstruction and lung collapse is an extremely rare occurrence. While these patients were treated with antifungal agents, unfortunately, half of them showed a suboptimal response.

Patient Concerns: A 45-year-old immunocompetent male was admitted to the hospital due to a cough, yellow phlegm, and dyspnea persisting for 5 months.

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Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture, pioneer transcription factors mediate "reprogramming" by opening new chromatin sites for expression that can attract transcription factors from the starting cell's enhancers. Here we report that SOX4 is sufficient to initiate hepatobiliary metaplasia in the adult mouse liver, closely mimicking metaplasia initiated by toxic damage to the liver.

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Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses, we find that resistance is reproducibly associated with an epithelial-to-mesenchymal transition (EMT), with EMT-transcription factors ZEB1 and SNAIL functioning as master genetic and epigenetic regulators of this effect. Acquired resistance in this model is not due to immunosuppression in the tumor immune microenvironment, disruptions in the antigen presentation machinery, or altered expression of immune checkpoints.

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Background: The demand for food-based anti-photoaging products is surging because of the rising recognition of health and beauty, as well as enhanced comprehension of the detrimental impact of ultraviolet (UV) radiation. This study aimed to investigate the potential of bioactive peptides derived from bovine elastin, specifically focusing on identifying novel elastase inhibitory peptides and assessing their photoprotective properties using bioinformatics techniques.

Results: A total of 48 bioactive peptides were screened in bovine elastin hydrolysate (EH) utilizing Peptide Ranker analysis.

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The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a mouse model of SCLC in which endogenous p53 expression can be conditionally and temporally regulated, we show that SCLC tumors maintain a requirement for p53 inactivation.

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Acquired resistance to immune checkpoint immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses, we found that tumors underwent an epithelial-to-mesenchymal transition (EMT) that resulted in reduced sensitivity to T cell-mediated killing. EMT-transcription factors (EMT-TFs) ZEB1 and SNAIL function as master genetic and epigenetic regulators of this tumor-intrinsic effect.

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Article Synopsis
  • Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin lymphoma, with about 40% of patients not responding to standard chemotherapy treatments, leading to severe health issues.
  • Researchers used a CRISPR-Cas9 library to discover that the E3 ubiquitin ligase KLHL6 plays a key role in making DLBCL cells resistant to chemotherapy by affecting the degradation of the NOTCH2 protein.
  • Targeting DLBCL tumors that are resistant to chemotherapy with drugs like nirogacestat and ipatasertib could effectively promote tumor destruction by interfering with the oncogenic pathways linked to KLHL6 or NOTCH2 mutations.
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DNA methylation (DNAm) is one of the major epigenetic mechanisms in humans and is important in diverse cellular processes. The variation of DNAm in the human population is related to both genetic and environmental factors. However, the DNAm profiles have not been investigated in the Chinese population of diverse ethnicities.

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Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture, pioneer transcription factors mediate "reprogramming" by opening new chromatin sites for expression that can attract transcription factors from the starting cell's enhancers. Here we report that Sox4 is sufficient to initiate hepatobiliary metaplasia in the adult liver.

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Staphylococcus aureus is one of the most prevalent threats to public health. Rapid detection with high sensitivity and targeted killing is crucial to curb its spread. Herein, a metal-bearing nanocomposite, consisting of a bimetallic nanoparticle and a metal-organic framework (Au/Ir@Cu/Zn-MOF) was constructed.

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Unlabelled: Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with a wide range of biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is often found mutated, resulting in the addition of a nuclear export signal and a shift of the protein to the cytoplasm (NPM1c). AMLs carrying this mutation have aberrant expression of the HOXA/B genes, whose overexpression leads to leukemogenic transformation.

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Pillar[5]arene-functionalized rhodium nanoparticles (Rh@CPA NPs) are first synthesized a facile one-pot chemical reduction method. Rh@CPA NPs with good reusability and biocompatibility show excellent catalytic activities in reducing toxic nitrophenols and azo dyes, and also exhibit superior photothermal ablation capability towards under 808 nm laser irradiation. This work suggests that the supramolecular capping strategy could be used to construct novel hybrid materials for various applications.

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Growing evidence suggests prevalence of transcriptional condensates on chromatin, yet their mechanisms of formation and functional significance remain largely unclear. In human cancer, a series of mutations in the histone acetylation reader ENL create gain-of-function mutants with increased transcriptional activation ability. Here, we show that these mutations, clustered in ENL's structured acetyl-reading YEATS domain, trigger aberrant condensates at native genomic targets through multivalent homotypic and heterotypic interactions.

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Many strategies have been adopted to constructmyocardium models, which are of great value to both drug cardiotoxicity evaluation and cardiovascular drug development. In particular, the recent rapid development of human-induced pluripotent stem cell (hiPSC) technology and the rise of the organ-on-a-chip technique have provided great potential to achieve more physiologically relevantmodels. However, recapitulating the key role of the vasculature endothelial layer in drug action on myocardium in the models is still challenging.

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Unlabelled: The chromatin reader eleven-nineteen leukemia (ENL) has been identified as a critical dependency in acute myeloid leukemia (AML), but its therapeutic potential remains unclear. We describe a potent and orally bioavailable small-molecule inhibitor of ENL, TDI-11055, which displaces ENL from chromatin by blocking its YEATS domain interaction with acylated histones. Cell lines and primary patient samples carrying MLL rearrangements or NPM1 mutations are responsive to TDI-11055.

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Background: Coenzyme Q10 (Q10) is a powerful lipophilic antioxidant with poor solubility in aqueous media. Curcumin (Cur) is a natural polyphenolic phytochemical molecule with poor aqueous solubility. The liposome is an improved administration of drugs because it is biocompatible and permeable for nutraceutical delivery.

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Article Synopsis
  • Inflammation significantly contributes to colorectal cancer (CRC), but the transition mechanisms from colitis to CRC are not well understood.
  • Recent research focuses on epigenetic changes, particularly histone modifications, in a mouse model of CRC induced by AOM-DSS, generating extensive epigenomic and transcriptomic data.
  • The findings highlight the importance of enhancer regions in the inflammation-cancer transition and identify OTX2 as a crucial tumor suppressor, offering new insights into the molecular mechanisms underlying colitis-associated cancer.
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