HERC4 modulates ovarian cancer cell proliferation by regulating SMO-elicited hedgehog signaling.

Background: HERC4 has been reported to have functions in several types of tumors, but its roles in ovarian cancer have not been studied yet.

Methods: Primary tissues from ovarian cancer patients and cell lines were collected for real-time PCR. Kaplan-Meier Plotter was used to predict the prognosis of ovarian cancer patients.

Positively charged membranes for dye/salt separation based on a crossover combination of Mannich reaction and prebiotic chemistry.

With the advent of increasingly loose nanofiltration membranes for dye desalination, synthesis methods based on interfacial polymerization and bio-inspired materials such as polydopamine (pDA) have been investigated. However, the long polymerization time of pDA greatly limits the synthesis and application of fast dye/salt separation membranes. In this work, prebiotic chemistry-inspired aminomalononitrile (AMN) was used as a binder to co-deposit the Mannich reaction of tetrakis(hydroxymethyl)phosphonium chloride (THPC) and polyethyleneimine (PEI) to form the positively charged selective layer rapidly.