Publications by authors named "Qingjian Zhu"
Article Synopsis
- Sir2-HerA is an antiphage system found in some bacteria, composed of an ATPase (HerA) and an effector (Sir2) that may have NADase activity.
- The mechanism of how Sir2-HerA defends against phage infections involves Sir2-dependent NAD depletion, which halts the growth of infected cells, but specifics were unclear until this study.
- Researchers discovered that SaHerA activates SaSir2’s NADase function through allosteric effects, leading to the formation of a complex that allows NAD to be cleaved by uncovering its active site.
