Publications by authors named "Qingjia Gong"
Programmed cell death 1 ligand 1 (PD-L1) is an important immunosuppressive molecule, which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1. The PD-L1 expression disorder plays an important role in the occurrence, development, and treatment of sepsis or other inflammatory diseases, and has become an important target for the treatment of these diseases. Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells with multiple differentiation potential.
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- Thyroid associated ophthalmopathy (TAO) is an autoimmune disease marked by T cell infiltration and is currently lacking effective treatments.
- Research indicates that the PD-1/PD-L1 pathway may play a role in TAO's progression by regulating T cell activity, but orbital fibroblasts from TAO patients don't express PD-L1.
- Introducing exogenous PD-L1 can reduce T cell-induced activation of orbital fibroblasts and lower inflammatory markers, suggesting that restoring PD-L1 could be a potential therapeutic approach for TAO.