Publications by authors named "Qinghui Kan"
Background: Developing a molecular signature associated with CD4 + T cell infiltration is essential for identifying biomarkers in abdominal aortic aneurysms (AAA). Establishing such a signature is vital for improving diagnostic accuracy and therapeutic strategies for AAA. This study focuses on CD4 + T cells, which are pivotal in the immune microenvironment of AAA, to pinpoint key targets.
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- Lower limb arterial occlusive disease is often treated with paclitaxel-coated balloons (PCBs), but post-treatment restenosis (re-narrowing) remains a major issue.
- The study found that the NLRP3 protein is activated during this process, promoting blood vessel cell proliferation, migration, and resistance to the effects of paclitaxel.
- Using a compound called JQ1 alongside paclitaxel showed promising results in preventing restenosis, suggesting a potential new treatment strategy for patients.
Background: Ruptured atherosclerotic plaques often precipitate severe ischemic events, such as stroke and myocardial infarction. Unraveling the intricate molecular mechanisms governing vascular smooth muscle cell (VSMC) behavior in plaque stabilization remains a formidable challenge.
Methods: In this study, we leveraged single-cell and transcriptomic datasets from atherosclerotic plaques retrieved from the gene expression omnibus (GEO) database.
PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.
Biochim Biophys Acta Mol Basis Dis
February 2024
Abdominal aortic aneurysm (AAA) is typically asymptomatic but a devastating cardiovascular disorder, with overall mortality exceeding 80 % once it ruptures. Some patients with AAA may also have comorbid metabolic syndrome (MS), suggesting a potential common underlying pathogenesis. Mitochondrial dysfunction has been reported as a key factor contributing to the deterioration of both AAA and MS.
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- N-methyladenosine (m6A) is a common RNA modification linked to various cardiovascular diseases, and while studies suggest its involvement in abdominal aortic aneurysm (AAA), the complete range of m6A regulators remains unclear.
- By analyzing mRNA levels of 17 m6A regulators, researchers identified three m6A methylation subtypes in AAA patients, distinguishing between more immunologically activated clusters and those associated with extracellular matrix stability.
- The study developed an m6Ascore model to assess m6A methylation patterns, finding that a high m6Ascore correlates with increased inflammatory activity in AAA, potentially guiding personalized treatment strategies in the future.