While apoptotic cell death is known to be central to the pathogenesis of radiation-induced liver injury (RILI), the mechanistic basis for this apoptotic activity remains poorly understood. N-methyladenosine (mA) modifications are the most common form of reversible methylation observed on lncRNAs in eukaryotic cells, with their presence leading to pronounced changes in the activity of a range of biological processes. The degree to which mA modification plays a role in the induction of apoptotic cell death in response to ionizing radiation (IR) in the context of RILI remains to be established.
View Article and Find Full Text PDFA series of antimony(III) triaryl corroles bearing different numbers of -pentafluorophenyl substituents was synthesized and evaluated as catalysts for electrocatalytic hydrogen evolution. Introduction of the electron-withdrawing pentafluorophenyl group to the corrole macrocycle led to a significant boost in electro-catalytic hydrogen evolution reaction (HER) activity in organic and aqueous media, highlighting the tunability of these complexes for enhanced catalytic activity.
View Article and Find Full Text PDFThis study aims to determine the effectiveness of combining pulsed dye laser (PDL) and ablative fractional carbon dioxide laser (AFCL) in the treatment of scars in pediatric patients, as well as to identify appropriate treatment parameters, initial treatment timing, and treatment intervals through a systematic literature review. A literature search was conducted between April 6, 2014 and April 6, 2024 in four databases to select studies on the effects of the combination of carbon dioxide fractional laser and pulsed dye laser therapy in children hypertrophic burn scars. This systematic literature review included 497 participants across 8 studies, with individual study sample sizes ranging from 17 to 125 participants.
View Article and Find Full Text PDFBackground: Salmonella enterica serovar Enteritidis (S. Enteritidis) is a global foodborne pathogen that poses a significant threat to human health, with poultry being the primary reservoir host. Therefore, addressing S.
View Article and Find Full Text PDFUnlabelled: The gut microbiota plays a crucial role in infant health, with its development during the first 1,000 days influencing health outcomes. Understanding the relationships within the microbiota is essential to linking its maturation process to these outcomes. Several network-based methods have been developed to analyze the developing patterns of infant microbiota, but evaluating the reliability and effectiveness of these approaches remains a challenge.
View Article and Find Full Text PDFTransl Cancer Res
November 2024
Background: Esophageal squamous cell carcinoma (ESCC) is a malignancy for which the incidence and mortality rates are among the highest worldwide. This study aimed to look for potential biomarkers that affect the prognosis of patients with ESCC.
Methods: The target gene was screened through differential expression gene analysis, cluster analysis, enrichment analysis, and construction of a protein-protein interaction (PPI) network, and then validated through clinical patient tissue RNA extraction and reverse transcription quantitative polymerase chain reaction (qRT-PCR).
Introduction: The goal of this study is to assess the efficacy and safety of LRa05, as an adjunct to the treatment of acute watery diarrhea in children.
Methods: Eligible diarrheal children were randomized into intervention group (IG, = 57) and control group (CG, = 54), and given probiotics or placebo, respectively.
Results: The total duration of diarrhea in the IG (121.
The geostationary orbit imaging spectrometer offers distinct advantages for diverse applications in remote sensing. To enhance swath and data richness, there is a growing trend toward spectrometers with broader fields of view (FOV) and extended slit lengths. Optical systems equipped with these features face significant challenges in aberration correction.
View Article and Find Full Text PDFSuperoxide anion (O), a significant reactive oxygen species (ROS) within biological systems, plays a widespread role in cellular function regulation and is closely linked to the onset and progression of numerous diseases. To unveil the pathological implications of O in these diseases, the development of effective monitoring techniques within biological systems is imperative. Small molecule fluorescent probes have garnered considerable attention due to their advantages: simplicity in operation, heightened sensitivity, exceptional selectivity, and direct applicability in monitoring living cells, tissues, and animals.
View Article and Find Full Text PDFTetrahymena piriformis belongs to the ciliated protists (ciliates), causing severe economic losses in aquaculture. Chemical drugs currently used usually have toxic side effects, and there is no specific drug against Tetrahymena. Therefore, it is an urgent need to identify new antiparasitic lead compounds.
View Article and Find Full Text PDFPrevious studies have documented important roles for microRNA-147 (miR-147) in inflammation, radiation-induced injury, cancer, and a range of other diseases. Murine lungs exhibit high levels of miRNA, mRNA, and lncRNA expression. However, very little research to date has focused on the lncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) networks associated with miR-147, and the regulation of lncRNAs and miRNAs in this setting remains poorly understood.
View Article and Find Full Text PDFThe goal of this study is to assess the efficacy and safety of Bifidobacterium animalis subsp. lactis BLa80, as an adjunct treatment for diarrhea in children with a randomized, double-blinded, placebo-controlled study design. Eligible diarrheal children, aged 0-3 years without the need for antibiotic treatment based on clinical diagnosis when recruited, were randomized into the intervention group (IG, n = 58, with probiotic) or the control group (CG, n = 53, placebo).
View Article and Find Full Text PDFFunctional constipation (FC) can seriously affect the physical and mental health of children. The goal of this study is to assess the efficacy and safety of Bifidobacterium animalis subsp. lactis XLTG11 in treating FC in children through a randomized, double-blinded, placebo-controlled approach.
View Article and Find Full Text PDFThe present study aimed to characterize the genotype distribution and clinical characteristics of HCV monoinfected and HCV/HIV coinfected patients in the Liangshan Prefecture, Sichuan Province, China. All the patients were divided into HCV monoinfection and HCV/HIV coinfection groups according to whether they were complicated with HIV infection. The data from the two groups were collected.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2023
Conductive ink deposited on flexible substrates through simple methods such as dyeing or printing is one of the most promising approaches for scalable fabrication of wearable electronics. However, excessive chemical additives or a complex preparation process has limited the practical applications of conductive inks. Herein, a highly stable and antibacterial AgNPs/CNT/rGO (SACR) conductive ink with the only assistance of sustainable silk sericin (SS) is developed through a green one-step strategy.
View Article and Find Full Text PDFThe unique layered structure and high conductivity of MXene materials make them highly promising for microwave absorption. However, the finite loss mechanism and severe agglomeration present challenging obstacles for ideal microwave absorbers, which could be effectively improved by constructing a three-dimensional (3D) porous structure. This study reports a 3D honeycomb MXene using a straightforward template method.
View Article and Find Full Text PDFTo date, over 200 families with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) and over 600 families with Birt-Hogg-Dubé (BHD) syndrome have been reported, with low incidence. Here, we describe a patient with suspected rare HLRCC complicated by BHD syndrome. The proband (II1) had characteristic cutaneous leiomyoma-like protrusions on the neck and back, a left renal mass and multiple right renal, liver and bilateral lung cysts.
View Article and Find Full Text PDFSince its discovery, poly (ADP-ribose) polymerase 1 (PARP-1) has been extensively studied due to its regulatory role in numerous biologically crucial pathways. PARP inhibitors have opened new therapeutic avenues for cancer patients and have gained approval as standalone treatments for certain types of cancer. With continued advancements in the research of PARP inhibitors, we can fully realize their potential as therapeutic targets for various diseases.
View Article and Find Full Text PDFIn this work, homochiral reduced imine cage was covalently bonded to the surface of the silica to prepare a novel high-performance liquid chromatography stationary phase, which was applied for the multiple separation modes such as normal phase, reversed-phase, ion exchange, and hydrophilic interaction chromatography. The successful preparation of the homochiral reduced imine cage bonded silica stationary phase was confirmed by performing a series of methods including X-ray photoelectron spectroscopy, thermogravimetric analysis, and infrared spectroscopy. From the extracted results of the chiral resolution in normal phase and reversed-phase modes, it was demonstrated that seven chiral compounds were successfully separated, among which the resolution of 1-phenylethanol reached the value of 3.
View Article and Find Full Text PDFAIDS Res Hum Retroviruses
August 2023
In this study, we characterized HIV-1 RNA and HIV-1 DNA genotyping drug resistance detection in patients with low-level viremia (LLV) in Liangshan, China. Whole blood samples were collected from HIV/AIDS patients who had received antiretroviral therapy (ART) for ≥6 months and whose HIV-1 RNA loads were 50-1,000 copies/mL for two consecutive times at least 1-month apart. The patients were enrolled from a county in Liangshan Yi Autonomous Prefecture, Sichuan Province, between May 2021 and May 2022.
View Article and Find Full Text PDFObjective: The aim of this study was to assess the efficacy and safety of Bifidobacterium animalis sp. Lactis XLTG11, as an adjunctive treatment for acute watery diarrhea in children, using a randomized, double-blinded, placebo-controlled study design.
Method: Eligible children with diarrhea were randomly assigned into one of two groups: an intervention group (IG, n = 35), which received conventional treatment plus the probiotic, and a control group (CG, n = 35), which received only conventional treatment.
Reduced imine cage (RCC3) was covalently bonded to the surface of silica spheres, and then the secondary amine group of the molecular cage was embedded in non-polar C10 for modification to prepare a novel RCC3-C10@silica HPLC stationary phase with multiple separation functions. Through infrared spectroscopy, thermogravimetric analysis and nitrogen adsorption-desorption characterization, it was confirmed that RCC3-C10 was successfully bonded to the surface of silica spheres. The resolution of RCC3-C10@silica in reversed-phase separation mode is as high as 2.
View Article and Find Full Text PDFBackground: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune disease characterized by skin or osteoarticular damage. SAPHO syndrome is often misdiagnosed or missed diagnosis due to lack of overall understanding of the disease by clinicians.
Purpose: To analyze the clinical symptoms and imaging features of six Han patients with SAPHO syndrome in order to provide reference for doctors to diagnose SAPHO syndrome.
A great amount of the population died due to living or working in an unhealthy environment, highlighting the critical role of environmental pollutants in inducing diseases. Microplastics are widespread environmental pollutants and have been found in various tissues of human beings, yet the risk of microplastics in the occurrence of disease, especially environmentally-related colitis, is unclear. This study focused on the effects of microplastics exposure on intestinal homeostasis and the initiation of colitis.
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