Inflammatory responses play a critical role in the progress of neurodegenerative disorders. MSC-Exos is considered to have an anti-inflammatory effect on the treatment strategy for brain injury. However, the therapeutic effect and possible mechanism of Exosomal miR-210 on microglia polarization-induced neuroinflammation and neurite outgrowth have not been reported.
View Article and Find Full Text PDFEndocr Metab Immune Disord Drug Targets
March 2023
Background: The healing of cutaneous wounds requires better strategies, which remain a challenge. Previous reports indicated that the therapeutic function of mesenchymal stem cells is mediated by exosomes. This work demonstrated the regenerative effects of engineered BMSCsderived Exosomal miR-542-3p in skin wound mouse models.
View Article and Find Full Text PDFObjective: This study investigated the effects of leptin on intestinal flora and inflammation in mice with high-fat diet (HFD)-induced obesity.
Methods: Mice were fed an HFD for 8 weeks; some were concurrently administered oral leptin for 4 weeks. Pathological changes in adipose tissue were detected using hematoxylin-eosin staining; endotoxin content in adipose tissue was measured by enzyme-linked immunosorbent assay.
Zhonghua Zheng Xing Wai Ke Za Zhi
March 2009
Objective: To introduce one-staged correction of nasal deformity and unilateral complete cleft lip in infancy and to observe the nasal development after the operation.
Methods: The unilateral complete cleft lip and nasal deformity were corrected in one stage in27 cases. They were followed up for several years.
Int J Gastrointest Cancer
January 2001
In this study, we report a metastatic model of Panc02 murine pancreatic adenocarcinoma. Parental Panc02cells were orthotopically implanted into the pancreas of syngeneic C57BL/6 mice. Tumor cells were isolatedfrom liver micrometastases 90 d after tumor implantation and established as a culture (Panc02-H1).
View Article and Find Full Text PDFPancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills themajority of patients who have it. Effective prevention is clearly the ultimate goal for eradicating this diseaseprovided that the effects of environmental and genetic elements on pancreatic cancer development arefully understood.
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