Programmed cell death 1 inhibitor sintilimab plus concurrent chemoradiotherapy for locally advanced pancreatic adenocarcinoma.

Background: Pancreatic adenocarcinoma, a malignancy that arises in the cells of the pancreas, is a devastating disease with unclear etiology and often poor prognosis. Locally advanced pancreatic cancer, a stage where the tumor has grown significantly but has not yet spread to distant organs, presents unique challenges in treatment. This article aims to discuss the current strategies, challenges, and future directions in the management of locally advanced pancreatic adenocarcinoma (LAPC).

Molecular mechanism of the effect of Gegen Qinlian decoction on COVID-19 comorbid with diabetes mellitus based on network pharmacology and molecular docking: A review.

To explore the potential mechanism of Gegen Qinlian decoction (GGQL) in the treatment of COVID-19 comorbid with diabetes mellitus (DM) through network pharmacology and molecular docking, and to provide theoretical guidance for clinical transformation research. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to screen the active compounds and targets of GGQL, the targets of COVID-19 comorbid with DM were searched based on Genecards database. Protein-protein interaction network was constructed using String data platform for the intersection of compounds and disease targets, the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of the intersection targets was performed using DAVID database.

Analyzing the electron trajectories in strong-field tunneling ionization with the phase-of-the-phase spectroscopy.

By numerically solving the time-dependent Schrödinger equation, we theoretically study strong-field tunneling ionization of Ar atom in the parallel two-color field which consists of a strong fundamental pulse and a much weaker second harmonic component. Based on the quantum orbits concept, we analyzed the photoelectron momentum distributions with the phase-of-the-phase spectroscopy, and the relative contributions of the two parts of the photoelectrons produced during the rising and falling edges of the adjacent quarters of the laser cycle are identified successfully. Our results show that the relative contributions of these two parts depend on both of the transverse and longitude momenta.

Intensity-dependent angular distribution of low-energy electrons generated by intense high-frequency laser pulse.

By solving the three-dimensional time-dependent Schrödinger equation, we investigate the angular distributions of the low-energy electrons when an intense high-frequency laser pulse is applied to the hydrogen atom. Our numerical results show that the angular distributions of the low-energy electrons which generated by the nonadiabatic transitions sensitively depend on the laser intensity. The angular distributions evolve from a two-lobe to a four-lobe structure as the laser intensity increases.

Low-energy photoelectron interference structure in attosecond streaking.

By numerically solving the time-dependent Schrödinger equation, we theoretically investigate the dynamics of the low-energy photoelectrons ionized by a single attosecond pulse in the presence of an infrared laser field. The obtained photoelectron momentum distributions exhibit complicated interference structures. With the semiclassical model, the originations for the different types of the interference structures are unambiguously identified.

Two-dimensional photoelectron holography in strong-field tunneling ionization by counter rotating two-color circularly polarized laser pulses.

Strong-field photoelectron holography (SFPH), originating from the interference of the direct electron and the rescattering electron in tunneling ionization, is a significant tool for probing structure and electronic dynamics in molecules. We theoretically study SFPH by counter rotating two-color circularly (CRTC) polarized laser pulses. Different from the case of the linearly polarized laser field, where the holographic structure in the photoelectron momentum distribution (PEMD) is clustered around the laser polarization direction, in the CRTC laser fields, the tunneling ionized electrons could recollide with the parent ion from different angles and thus the photoelectron hologram appears in the whole plane of laser polarization.

Frustrated tunneling ionization in the elliptically polarized strong laser fields.

We theoretically investigated frustrated tunneling ionization (FTI) in the interaction of atoms with elliptically polarized laser pulses by a semiclassical ensemble model. Our results show that the yield of frustrated tunneling ionization events exhibits an anomalous behavior which maximizes at the nonzero ellipticity. By tracing back the initial tunneling coordinates, we show that this anomalous behavior is due to the fact that the initial transverse velocity at tunneling of the FTI events is nonzero in the linear laser pulses and it moves across zero as the ellipticity increases.

Determination of the Ionization Time Using Attosecond Photoelectron Interferometry.

Laser-induced electron tunneling ionization from atoms and molecules plays as the trigger for a broad class of interesting strong-field phenomena in attosecond community. Understanding the time of electron tunneling ionization is vital to achieving the ultimate accuracy in attosecond metrology. We propose a novel attosecond photoelectron interferometer, which is based on the interference of the direct and near-forward rescattering electron wave packets, to determine the time information characterizing the tunneling process.

The effects of recombinant human granulocyte colony-stimulating factor mouthwash on radiotherapy-induced oral mucositis in locally advanced nasopharyngeal carcinoma patients.

Background: Acute oral mucositis is a common complication of radiotherapy for nasopharyngeal carcinoma (NPC) patients.

Objectives: The aim of the study was to observe the effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on radiotherapy-induced oral mucositis in locally advanced NPC patients.

Material And Methods: The study involved 64 locally advanced NPC patients that were randomly allocated to receive either rhG-CSF mouthwash (2 μg/mL rhG-CSF; group A, n = 34) or a compounded mouth rinse (10 μg/mL vitamin B12, 0.

Hypoxia regulates CD44 expression via hypoxia-inducible factor-1α in human gastric cancer cells.

Hypoxia induces proliferation and invasion in cancer cells via hypoxia-inducible factor (HIF)-1α. The cell adhesion molecule cluster of differentiation (CD) 44 has been associated with increased cell invasion and metastasis. Whether hypoxia regulates the expression of CD44 in gastric cancer cells remains to be established.

S-1 plus gemcitabine chemotherapy followed by concurrent radiotherapy and maintenance therapy with S-1 for unresectable pancreatic cancer.

Aim: To investigate the feasibility and efficacy of the combination of S-1 with gemcitabine followed by oral S-1 with concurrent radiotherapy (intensity modulated radiotherapy, IMRT) and maintenance therapy with S-1 for locally advanced pancreatic cancer.

Methods: Subjects selected in the study were patients who had unresectable and locally advanced pancreatic cancer without distant metastases, adequate organ and marrow functions, an Eastern Cooperative Oncology Group performance status of 0-1 and no prior anticancer therapy. Initially the subjects received two cycles of chemotherapy, oral administration of S-1 40 mg/m(2) twice daily from day 1 to day 14 of a 21-d cycle, with 30-min intravenous infusions of gemcitabine 1000 mg/m(2) on day 1 and day 8.

Early efficacy of Endostar combined with chemoradiotherapy for advanced cervical cancers.

The aim of this study was to investigate the early outcome of Endostar combined with chemoradiotherapy for advanced cervical cancer. Fifty-two cases (FIGO IIb to IVa) were divided randomly into two groups, receiving chemoradiotherapy alone (CRT group) and Endostar combined with chemoradiotherapy (CRT+E group). For the patients in the CRT+E group, Endostar was administered daily with the dosage of 7.

Early efficacy of taxotere and cisplatin chemo-radiotherapy for advanced cervical cancer.

The aim of this study was to investigate the early outcome of the taxotere and cisplatin chemoradiotherapy to the advanced cervical cancer. Fifty-six cases with cervical cancer (FIGO II b to IVa) were divided randomly into two groups: radiotherapy alone (28 cases) and radiation plus chemotherapy (TP) group. There was no difference of radiotherapy between the two groups.

[Analysis of the initial efficacy of nedaplatin combined with megestrol in concurrent chemoradiotherapy for advanced cervical cancer].

Objective: To investigate the early efficacy of nedaplatin combined with megestrol in concurrent chemoradiotherapy for advanced cervical cancer.

Methods: Forty-two cases of cervical cancer (FIGO IIb to IVa) were divided randomly into two groups: radiotherapy alone (21 cases) and radiation plus chemotherapy (Nedaplatin) group. The same radiotherapy was given to the two groups.