[Glucose transporters in lymphocytes: expression and effects on lymphocyte functions].

Glucose uptake by lymphocytes is dependent on the facilitative glucose transporters (GLUT1, GLUT3, GLUT4, and GLUT6) of the GLUT family and the Na-coupled glucose transporter SGLT1. GLUTs and SGLTs are widely expressed in mammals, and their expression and functions may affect cell development, homeostasis, activation, and differentiation. This article details the important functions of several GLUTs and SGLTs in lymphocytes and points out that glucose transporters play a key role in supplying energy for lymphocytes, maintaining intracellular glucose homeostasis, and improving the efficiency of immune responses, which reflect their key roles in signal transduction.

A Prognostic Model Based on Nutritional Indexes for Patients With Pan-Cancer: A Real-World Cohort Study.

Background: The aim was to identify the nutritional indexes, construct a prognostic model, and develop a nomogram for predicting individual survival probability in pan-cancers.

Methods: Nutritional indicators, clinicopathological characteristics, and previous major treatment details of the patients were collected. The enrolled patients were randomly divided into training and validation cohorts.

Creating CoRu Dual Active Sites Codecorated Stable Porous Ceria Support for Enhanced Li-CO Batteries Cathodes.

Lithium-carbon dioxide (Li-CO) battery represents a high-energy density energy storage with excellent real-time CO enrichment and conversion, but its practical utilization is hampered by the development of an excellent catalytic cathode. Here, the synergistic catalytic strategy of designing CoRu bimetallic active sites achieves the electrocatalytic conversion of CO and the efficient decomposition of the discharge products, which in turn realizes the smooth operation of the Li-CO battery. Moreover, obtained support based on metal-organic frameworks precursors facilitates the convenient diffusion and adsorption of CO, resulting in higher reaction concentration and lower mass transfer resistance.

Causal association of immune cells and endometriosis: a Mendelian randomization study.

Objective: To investigate the causal effect of immune cells on endometriosis (EMS), we performed a Mendelian randomization analysis.

Methods: Mendelian randomization (MR) uses genetic variants as instrumental variables to investigate the causal effects of exposures on outcomes in observational data. In this study, we conducted a thorough two-sample MR analysis to investigate the causal relationship between 731 immune cells and endometriosis.

Causal relationships between modifiable risk factors and polycystic ovary syndrome: a comprehensive Mendelian randomization study.

Background: Polycystic Ovary Syndrome (PCOS) is a heritable condition with an as yet unclear etiology. Various factors, such as genetics, lifestyle, environment, inflammation, insulin resistance, hyperandrogenism, iron metabolism, and gut microbiota, have been proposed as potential contributors to PCOS. Nevertheless, a systematic assessment of modifiable risk factors and their causal effects on PCOS is lacking.

Unique Hierarchically Structured High-Entropy Alloys with Multiple Adsorption Sites for Rechargeable Li-CO Batteries with High Capacity.

Lithium-carbon dioxide (Li-CO) batteries offer the possibility of synchronous implementation of carbon neutrality and the development of advanced energy storage devices. The exploration of low-cost and efficient cathode catalysts is key to the improvement of Li-CO batteries. Herein, high-entropy alloys (HEAs)@C hierarchical nanosheet is synthesized from the simulation of the recycling solution of waste batteries to construct a cathode for the first time.

One-Stone-for-Two-Birds Strategy for VSe to Enable High Capacity and Long-Life Zinc Storage.

Based on a specific zinc storage mechanism and excellent electronic conductivity, transition metal dichalcogenides, represented by vanadium diselenide, are widely used in aqueous zinc-ion battery (AZIB) energy storage systems. However, most vanadium diselenide cathode materials are presently limited by low specific capacity and poor cycling life. Herein, a simple hydrothermal process has been proposed for obtaining a vanadium diselenide cathode for an AZIB.

Predicting radiation pneumonitis in lung cancer: a EUD-based machine learning approach for volumetric modulated arc therapy patients.

Purpose: This study aims to develop an optimal machine learning model that uses lung equivalent uniform dose (lung EUD to predict radiation pneumonitis (RP) occurrence in lung cancer patients treated with volumetric modulated arc therapy (VMAT).

Methods: We analyzed a cohort of 77 patients diagnosed with locally advanced squamous cell lung cancer (LASCLC) receiving concurrent chemoradiotherapy with VMAT. Patients were categorized based on the onset of grade II or higher radiation pneumonitis (RP 2+).

Revealing the construction of CuOCe interfacial sites via increased support utilization for enhanced CO electroreduction and Li-CO batteries.

Leveraging designed electronic oxide-metal interactions (EOMI), cerium-supported copper demonstrates remarkable competitiveness in the carbon dioxide reduction reaction (CORR). Nevertheless, the limited utilization efficiency of conventional cerium oxide (CeO) support hampers the EOMI effect. Furthermore, a comprehensive understanding of the influence of distinct crystalline surfaces of CeO on the loaded active copper (Cu) species remains elusive.

Resveratrol reverses Palmitic Acid-induced cow neutrophils apoptosis through shifting glucose metabolism into lipid metabolism via Cav-1/ CPT 1-mediated FAO enhancement.

Elevated plasma nonesterified fatty acids (NEFAs) affect neutrophils function and longevity during the periparturient period in dairy cows. Previous research has shown that resveratrol (RSV) may protect cell viability from NEFA-induced damage by regulating energy metabolism. However, it is unclear whether RSV has a protective effect on palmitic acid (PA)-treated neutrophils.

One-Pot synthesis of flavones catalyzed by an Au-mediated covalent organic framework.

Covalent organic frameworks (COFs) are excellent candidates for rationally designed metal-coordinated catalysts due to their porous structures and adjustable organic building blocks. In this work, a two-dimensional (2D) COF with novel fxt topology was synthesized. The newly devised COF had been fully characterized by a range of spectroscopic and microscopic techniques.

Synthesis of a Novel Spherical-Shell-Structure Polymerized Ionic Liquid Microsphere PILM/Au/Al(OH) Catalyst for Benzyl Alcohol Oxidation.

In order to selectively oxidize benzyl alcohol, a novel noble metal catalyst based on polymer ionic liquids with a core-shell structure was created. First, polymer ionic liquid microspheres (PILMs) were prepared by free radical polymerization. Second, the in situ adsorption of Au nanoparticles on the surface of PILMs was accomplished, thanks to the strong electrostatic interaction between N atoms and metal ions on the diazole ring of PILMs.

Cancer-associated fibroblasts facilitate DNA damage repair by promoting the glycolysis in non-small cell lung cancer.

Radiotherapy is an essential treatment modality for the management of non-small cell lung cancer (NSCLC) patients. Tumor radioresistance is the major factor limiting the efficacy of radiotherapy in NSCLC patients. Our study aimed to reveal whether cancer-associated fibroblasts (CAFs), one main component of the tumor microenvironment, regulated DNA damage response of NSCLC cells following irradiation and clarify the involved mechanisms.

Reaction Site Designation by Intramolecular Electric Field in Tröger's-Base-Derived Conjugated Microporous Polymer for Near-Unity Selectivity of CO Photoconversion.

To facilitate solar-driven overall CO and H O convsersion into fuels and O , a series of covalent microporous polymers derived from Tröger's base are synthesized featuring flexural backbone and unusual charge-transfer properties. The incorporation of rigid structural twist Tröger's base unit grants the polymers enhanced microporosity and CO adsorption/activation capacity. Density function theory calculations and photo-electrochemical analyses reveal that an electric dipole moment (from negative to positive) directed to the Tröger's base unit is formed across two obliquely opposed molecular fragments and induces an intramolecular electric field.

Pendant Length-Dependent Electrochemical Performances for Conjugated Organic Polymers as Solid-State Polymer Electrolytes in Lithium Metal Batteries.

The development of solid-state polymer electrolytes (SPEs) has been plagued by poor ionic conductivity, low ionic transference number, and limited electrochemical potential window. The exploitation of ionized SPEs is a feasible avenue to solve this problem. Herein, conjugated organic polymers (COPs) with excellent designability and rich pore structures have been selected as platforms for exploration.

Prediction of radiation-induced acute skin toxicity in breast cancer patients using data encapsulation screening and dose-gradient-based multi-region radiomics technique: A multicenter study.

Purpose: Radiation-induced dermatitis is one of the most common side effects for breast cancer patients treated with radiation therapy (RT). Acute complications can have a considerable impact on tumor control and quality of life for breast cancer patients. In this study, we aimed to develop a novel quantitative high-accuracy machine learning tool for prediction of radiation-induced dermatitis (grade ≥ 2) (RD 2+) before RT by using data encapsulation screening and multi-region dose-gradient-based radiomics techniques, based on the pre-treatment planning computed tomography (CT) images, clinical and dosimetric information of breast cancer patients.

Dexamethasone enhances glucose uptake by SGLT1 and GLUT1 and boosts ATP generation through the PPP-TCA cycle in bovine neutrophils.

Background: Clinical dexamethasone (DEX) treatment or stress in bovines results in extensive physiological changes with prominent hyperglycemia and neutrophils dysfunction.

Objectives: To elucidate the effects of DEX treatment in vivo on cellular energy status and the underlying mechanism in circulating neutrophils.

Methods: We selected eight-month-old male bovines and injected DEX for 3 consecutive days (1 time/d).

Capilliposide from promotes terminal differentiations and reverses paclitaxel resistance in A2780T cells of human ovarian cancer by regulating Fos/Jun pathway.

Objective: To investigate the potential effect of capilliposide (LCC) on the chemo sensitivity and the stemness of human ovarian cancer cells.

Methods: Cell Counting Kit-8 (CCK8) was used to measure the IC values. The apoptosis of cells was measured through flow cytometry.

Accelerating Nickel-Based Molecular Construction via DFT Guidance for Advanced Photocatalytic Hydrogen Production.

Understanding the nickel-based molecular catalyst structure and functional relationship is crucial for catalytic hydrogen production in aqueous solutions. Density functional theory (DFT) provides mature theoretical knowledge for efficient catalyst design, significantly reducing catalyst synthesis time and energy consumption. In the present work, three molecular catalysts, Ni(qbz)(pys) (qbz = 2-quinoline benzimidazole) (), Ni(qbo)(pys) (qbo = 2-quinoline benzothiazole) (), and Ni(pbz)(pys) (pbz = 4-chloro-2,2-pyridylbenzimidazole) () (pys = 2-mercaptopyridine), were designed and synthesized and exhibit a high performance for H generation in aqueous solution with a lamp (λ ≥ 400 nm) under visible light irradiation.

A nanoflower-like polypyrrole-based cobalt-nickel sulfide hybrid heterostructures with electrons migration to boost overall water splitting.

The development of high-efficiency and cost-effective difunctional electrocatalysts for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) are highly attractive to fulfill the practical water electrolysis. Herein, a novel low-cost difunctional cobalt-nickel sulfide (CoS/NiS) flower-like heterostructures are purposely loaded on the surface of polypyrrole (PPy) nanosheets on nickel foam (NF) via feasible and efficient electrodeposition and hydrothermal tactics. The unique hierarchical architecture of the PPy nanosheets and strong electron interaction in the CoS/NiS nanohybrid effectively offer sufficient specific surface area and regulate electronic configuration for expediting the electrocatalytic process.

NEFAs Influence the Inflammatory and Insulin Signaling Pathways Through TLR4 in Primary Calf Hepatocytes .

Transition dairy cows are often in a state of negative energy balance because of decreased dry matter intake and increased energy requirements, initiating lipid mobilization and leading to high serum β-hydroxybutyrate (BHBA) and non-esterified fatty acid (NEFAs) levels, which can induce ketosis and fatty liver in dairy cows. Inflammation and insulin resistance are also common diseases in the perinatal period of dairy cows. What is the relationship between negative energy balance, insulin resistance and inflammation in dairy cows? To study the role of non-esterified fatty acids in the nuclear factor kappa beta (NF-κB) inflammatory and insulin signaling pathways through Toll-like receptor 4 (TLR4), we cultured primary calf hepatocytes and added different concentrations of NEFAs to assess the mRNA and protein levels of inflammatory and insulin signaling pathways.

Estrogen Regulates Glucose Metabolism in Cattle Neutrophils Through Autophagy.

Hypoglycemia resulting from a negative energy balance (NEB) in periparturient cattle is the major reason for a reduced glycogen content in polymorphonuclear neutrophils (PMNs). The lack of glycogen induces PMNs dysfunction and is responsible for the high incidence of perinatal diseases. The perinatal period is accompanied by dramatic changes in sex hormones levels of which estrogen (17β-estradiol, E2) has been shown to be closely associated with PMNs function.

AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1.

AZD3759 is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) on the basis of gefitinib and has been proven to enter the central nervous system. Although the promising antitumor effects of AZD3759 on non-small cell lung cancer (NSCLC) have been demonstrated in clinical trials, the regulatory effects of this inhibitor on the antitumor efficacy of radiation (RA) are unclear. The present study aimed to compare the effects of AZD3759 and osimertinib on RA efficacy in NSCLC and explore the potential mechanism of action of AZD3759.

AZD3759 inhibits glioma through the blockade of the epidermal growth factor receptor and Janus kinase pathways.

Glioma is an intracranial malignant tumor with high morbidity in China. Limited efficacy has been achieved in the treatment of glioma through the application of epidermal growth factor receptor (EGFR) inhibitors, which is reported to be related to the poor permeability of the brain-blood barrier (BBB) to EGFR inhibitors. AZD3759 and osimertinib are both BBB-penetrating EGFR inhibitors.

CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR-506-3p/NFIB axis.

Circular RNAs (circRNAs) play vital regulatory roles in the development of ovarian cancer (OC). However, the functions of circRNA Atlastin GTPase 2 (circATL2) in paclitaxel (PTX) resistance of OC are still unclear. As a result, circATL2 was upregulated in PTX-resistant OC tissues and cells.