A new sesquiterpene coumarins from Kitagawa.

A new sesquiterpene coumarin, bungeanin A (), together with four known sesquiterpene coumarins, were isolated from the whole plants of Kitagawa. The structure of bungeanin A was elucidated by analysis of its spectroscopic data, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR spectroscopy.

HPLC analysis of 16 compounds from .

Objective: To establish a high-performance liquid chromatographic method (HPLC) for the simultaneous determination of 16 compounds from .

Methods: HPLC was used to analyze 16 quality indicators of . The HPLC conditions were as follows: Agilent Eclipse Plus C column (250 mm × 4.

Ginsenoside Rg1 Inhibits STAT3 Expression by miR-15b-5p to Attenuate Lung Injury in Mice with Type 2 Diabetes Mellitus-Associated Pulmonary Tuberculosis.

Type 2 diabetes mellitus (T2DM) has been regarded as a critical risk factor for pulmonary tuberculosis (PTB). Ginsenoside Rg1 has been identified as a potential therapeutic agent for T2DM by suppressing the inflammatory response. However, the effect of Rg1 on T2DM-associated PTB has not been reported.

A new abietane diterpene tuurgan a from .

Five abietane diterpenes compounds were separated from petroleum ether extraction sites of ethanol extract of , and Compound was identified as a new abietane diterpenes compound by NMR and mass spectrometry, named as Tuurgan A of ; and Compounds - separated from for the first time were identified as Ferruginol (), Taxodione (), Caryopterisoid Q (), and Huperphlegmarin B (). The anti-lung cancer activity of the Compounds - were determined, which results showed that they all had high A549 cytotoxicity.

Structural elucidation and α‑glucosidase inhibitory activity of a new xanthone glycoside from (L.) Fries es Nym.

A new xanthone glycoside, 1,8-dihydroxyl-2,5-dimethoxy-xanthone-6-O--D-glucoside (), along with two known xanthone glycosides and two flavonoid glycosides were isolated from the aerial parts of (L.) Fries es Nym. The structure of was elucidated by analysis of its spectroscopic data, including UV, IR, HR-ESI-MS and extensive 1 D and 2 D NMR techniques.

Two new glycosides from (L.) Soják.

Two new glycosides, namely panalaside A () and panalaside B () were isolated from from (L.) Soják. The structures of and were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1 D and 2 D NMR techniques.

Fracture Behavior of Mullite Reticulated Porous Ceramics for Porous Media Combustion.

Mullite reticulated porous ceramics (RPC) are one of the key components for porous media burner, the mechanical properties of mullite RPC decided the service life of the burner. However, the irregularities of cellular structure made it difficult to reveal the fracture behavior of mullite RPCs. In this study, the three-dimensional (3-D) structures of mullite RPCs were analyzed by X-ray computed tomography.

Two new compounds from supercritical fluid extract of L.

Two new compounds, namely integrin A () and integrin B (), were isolated from the supercritical fluid extract (SFE) of L. Their structures were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

Structure elucidation and NMR assignments of a new sesquiterpene of volatile oil from Willd.

A new sesquiterpene, artefrigin (), together with four known sesquiterpenes were isolated from the volatile oil of Willd. The structure of was elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

Structure elucidation and antimicrobial activities of five compounds from Artemisia integrifolia L.

A new compound, integracid (1), together with four known compounds were isolated from the dichloromethane (CH2Cl2) extract from Artemisia integrifolia L. The structures of compounds (1-5) were elucidated by spectroscopic methods, including ultraviolet, infrared (IR), high resolution-electrospray ionization-mass spectrometry (HR-ESI-MS) and extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) techniques, and by comparison with data reported in the references. Antibacterial activities of the compounds were evaluated against various bacteria.

Synthesis and antitumor activity of sacroflavonoside.

Sacroflavonoside, a new derivative of diphenylethene, was isolated from , which have been found to possess the inhibitory effect on the proliferation of gastric carcinoma cells (MKN-45) in our previous studies. With anisaldehyde (SM-A) as starting material, the sacroflavonoside was synthesized by nucleophilic addition, electrophilic substitution and dehydration cyclization. The structure of sacroflavonoside was established by 1 D (H NMR and C NMR) and 2 D-NMR (HSQC and HMBC) spectral analysis.

Structure elucidation and NMR assignments of a new alkaloid from (L.) Soják.

A new alkaloid, named as panalasin (), was isolated from the ethyl acetate extract from (L.) Soják. The structure of was elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

Two new compounds from Krasch.

Two new compounds, named ordosacid A () and ordosacid B (), along with four known compounds: 3,4-dihydroxybenzaldehyde (), -hydroxybenzoic acid (), -hydroxycinnamic acid () and -hydroxycinnamic acid (), were isolated from the ethyl acetate extract of Krasch. The structures of new compounds were elucidated on the basis of spectroscopic methods including UV, IR, ESI-MS, 1D NMR, 2D NMR, HR-ESI-MS and modified Mosher's method.

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.

L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339.

Isolation and structure elucidation of two new compounds from artemisia .

Two new compounds, namely arteordoyn A () and arteordoyn B (), together with four known compounds, were isolated from the petroleum ether extract of Krasch. The structures elucidation of and were carried out by 1D-NMR (H and C NMR), 2D-NMR (COSY, HSQC, HMBC and NOESY) and HR-ESI-MS spectral analysis.

Structure elucidation and NMR assignments of a new dihydrochalcone from Empetrum nigrum subsp. asiaticum (Nakai ex H.Ito) Kuvaev.

A new dihydrochalcone, namely 2',5'-dimethyl-3'-methoxy-4',6'-dihydroxyl-dihydrochalcone () together with five known compounds were isolated from the CHCl extract from L. var. K.

Randomized, Double-Blind, Placebo-Controlled Studies to Assess Safety and Prophylactic Efficacy of Naphthoquine-Azithromycin Combination for Malaria Prophylaxis in Southeast Asia.

New prophylactic drugs against malaria infections are urgently needed. We conducted randomized, double-blind, placebo-controlled, phase 2 trials of a new antimalarial drug combination, naphthoquine-azithromycin (NQAZ), to determine its safety and protective efficacy in a low-endemicity area of Southeast Asia. In the first trial, 127 healthy volunteers were randomized to receive two single doses of either 400 mg of NQAZ (200 mg of each drug), 800 mg of NQAZ (400 mg of each drug), or placebo on day 0 and day 30.

Structure elucidation and NMR assignments of a new triterpenoid from Ixeris chinensis.

A new triterpenoid, namely 3β-hydroxy-13β,28-epoxyolean-11-enyl trans-caffeate (1), was isolated from the EtOAc extract from Ixeris chinensis Nakai. The structures of 1 were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

Structure elucidation and NMR assignments of an alkaloid from Ixeris chinensis Nakai.

A new alkaloid, 2-amino-1,6-dihydro-pyridine-5-carbaldehyde (1), together with four known compounds, namely 4-hydroxybenzaldehyde (2), 4-hydroxyacetophenone (3), acetophenone-4-O-β-d-glucoside (4), 2-hydroxyl-6-methoxyacetophenone-4-O-β-d-glucoside (5), were isolated from the CHCl extract from Ixeris chinensis Nakai. The structures of 1 was elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

Two New Compounds from Artemisia sacrorum.

Two new compounds, named as sacric acid A (1) and sacric acid B (2), were isolated from the EtOAc extract of Artemisia sacrorum Ledeb. This is the first report on the structure elucidation of these compounds based on UV, IR, and extensive ID and 2D NMR spectroscopic, and ESI-MS techniques.

High-speed countercurrent chromatography isolation of flavans from Ixeris chinensis and their identification by NMR spectroscopy.

High-speed countercurrent chromatography, combined with macroporous resin chromatography were applied to the separation and purification of flavans from Ixeris chinensis. Four flavans, namely, 5-methoxy-7,4'-dihydroxyflavan-3-ol (1), 5,7-dimethoxy-4'-hydroxyflavan-3-ol (2), 5,7-dimethoxy-4'-hydroxyflavan (3), and 5,7-dimethoxy-8-methyl-4'-hydroxyflavan (4), were obtained from I. chinensis for the first time.

Anti-inflammatory effects, nuclear magnetic resonance identification, and high-performance liquid chromatography isolation of the total flavonoids from Artemisia frigida.

The aerial parts of Artemisia frigida Willd. are used to treat joint swelling, renal heat, abnormal menstruation, and sore carbuncle. The anti-inflammatory effects of A.

[Study on Chemical Constituents of Panzeria alaschanica].

Objective: To study the chemical constituents of the ethyl acetate extract from Panzeria alaschanica.

Methods: The chemical constituents of ethyl acetate extract from Panzeria alaschanica were isolated and purified by silica gel. Their structures were i- dentified by means of spectra.

Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum.

The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay.