Publications by authors named "Qinghe Li"

Bacterial infections remain an important cause of morbidity in poultry production. The molecular characteristics and dynamic changes in immune cell populations after bacterial infection have yet to be fully understood. Beijing-You chicken and Cobb broiler, two broiler breeds with different disease resistance, were infected with Salmonella typhimurium, and inflammation models were constructed.

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Ubiquitination of proteins is involved in numerous life activities. In poultry, several ubiquitin ligases tightly control the innate immune response, imbalance of which may result in autoimmune diseases and seriously impair poultry growth, development, and productivity. LNX1, an E3 ubiquitin ligase, catalyzes the ubiquitination and subsequent degradation of specific substrate proteins.

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As the adaptor protein that determines substrate specificity of the Cul3-SPOP-Rbx1 E3 ligase complex, SPOP is involved in numerous biological processes. However, its physiological connections with adipogenesis and thermogenesis remain poorly understood. In the current study, we report that the conditional knockout of Spop in mice results in substantial changes in protein expression, including the upregulation of a critical factor associated with thermogenesis, UCP1.

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During the process of dune vegetation restoration, understanding how grazing disturbance affects the relationship between plant species is a critical issue in ecological studies. However, there is insufficient evidence on the changes in the interaction between dominant shrubs and understory vegetation under grazing behavior. We aimed to study how grazing and dune stabilization affects the relationship between Caragana microphylla and understory vegetation.

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Article Synopsis
  • Desert shrubs are essential for combating desertification and enhancing plant growth, but their development is often hindered by drought conditions.
  • This research examined 19 desert shrub species from northern China to understand the hydraulic traits of their roots, stems, and leaves, focusing on how these organs work together under water stress.
  • Key findings revealed a trade-off between water uptake efficiency and stem embolism resistance, hydraulic differences between stems and leaves, and strong desiccation resistance in leaves, which helps maximize carbon gain during limited growing periods.
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  • Traditional neuroimaging studies often focus on group analyses, missing out on individual differences in brain connectivity, which is crucial for understanding major depressive disorder (MDD).
  • This study aims to combine individualized functional and structural connectivity with machine learning to differentiate between people with MDD and healthy controls.
  • A total of 182 MDD patients and 157 healthy controls were involved, using advanced imaging techniques and statistical tests to assess connectivity differences, leading to the development of a support vector machine model for classification.
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Previous studies have found alterations in the local regional homogeneity of brain activity in individuals diagnosed with major depressive disorder. However, many studies have failed to consider that even during resting states, brain activity is dynamic and time-varying. The lack of investigation into the dynamic regional homogeneity has hindered the discovery of biomarkers for depression.

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Shrubs are a key component of desert ecosystems, playing a crucial role in controlling desertification and promoting revegetation, yet their growth is often impeded by drought. Leaf hydraulic traits and economic traits are both involved in the process of water exchange for carbon dioxide. Exploring the characteristics, relationships, and anatomical basis of these two suites of traits is crucial to understanding the mechanism of desert shrubs adapting to the desert arid environment.

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Hippocampal plasticity is closely related to physiological brain functions such as learning and memory. However, the effect of toll-like receptor 4 (TLR4) activation on hippocampal plasticity after neonatal hypoxic-ischaemic brain damage (HIBD) remains unclear. In our study, seven-day-old rat pups were randomly categorised into three groups: control, hypoxic-ischemia (HI), and HI + TAK-242 (TAK-242).

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Aims: Prostate cancer patients face impaired body image and psychological distress during the diagnosis and treatment of the disease, which leads to changes in mood, cognition and behavior. Psychological resilience has been shown to buffer shocks and stresses from the disease. Therefore, this study investigates the relationship between family functioning and psychological resilience in prostate cancer patients and the mediating role of self-efficacy between family functioning and psychological resilience to provide a relevant theoretical basis for improving patients' psychological status by providing relevant theoretical basis.

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Article Synopsis
  • Major depressive disorder (MDD) shows significant alterations in white-matter functional connectivity (WM-IVFC) compared to healthy controls, highlighting a distinct neurobiological aspect of the disorder.
  • The study utilized functional MRI and gene expression analysis to identify WM-IVFC changes linked to various cognitive and behavioral functions, including sensorimotor processes and higher-order thinking.
  • The findings suggest that WM-IVFC not only helps distinguish MDD patients from healthy individuals but also effectively predicts the severity of depression and suicide risk, offering insights into MDD's clinical variability.
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Semen volume is an important economic trait of broilers and one of the important indices for continuous breeding. The objective of this study was to identify genes related to semen volume through transcriptome analysis of the testis tissue of white feather broilers. The testis samples with the highest semen volume (H group, n = 5) and lowest semen volume (L group, n = 5) were selected from 400-day-old roosters for transcriptome analysis by RNA sequencing.

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Salmonella has been one of the most important factors restricting the development of the poultry industry and also poses great threat to public health. To get insight into molecular alterations that occur during bacterial infection, we sequenced the cecal tonsil transcriptome in 2 chicken breeds (Beijing-You and Cobb) known to have differing resistance to Salmonella. The 28-day-old chickens were orally challenged by 1.

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The recent oscillation events in offshore wind farms (OWFs) connected via a modular multilevel-converter-based HVDC (MMC-HVDC) system are developing towards a wider frequency band, which causes complex a small-signal interaction phenomenon and difficulties in the stability analysis and control. In this paper, the wideband dynamic interaction mechanism is investigated based on the impedance analysis method and an improved control strategy using an optimization algorithm is proposed to improve the small-signal stability and reduce the oscillation risks. First, the detailed impedance models of the grid-connected system are established considering the distribution characteristics of the submarine cable, control delay and frequency coupling effect.

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Affected by the pressure and constraints of available resources, plant growth and development, as well as plant life history strategies, usually vary with environmental conditions. Plant buds play a crucial role in the life history of woody plants. is a common dominant woody species in desertified areas of northern China and its growth is critical to the desert ecosystem.

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negatively impacts the poultry industry and threatens animals' and humans' health. The gastrointestinal microbiota and its metabolites can modulate the host's physiology and immune system. Recent research demonstrated the role of commensal bacteria and short-chain fatty acids (SCFAs) in developing resistance to infection and colonization.

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Introduction: Investigating the genetic markers and genomic signatures related to chicken meat production by combing multi-omics methods could provide new insights into modern chicken breeding technology systems.

Object: Chicken is one of the most efficient and environmentally friendly livestock, especially the fast-growing white-feathered chicken (broiler), which is well known for high meat yield, but the underlying genetic basis is poorly understood.

Method: We generated whole-genome resequencing of three purebred broilers (n = 748) and six local breeds/lines (n = 114), and sequencing data of twelve chicken breeds (n = 199) were obtained from the NCBI database.

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To identify genes that respond to increased nitrogen and assess the involvement of the chlorophyll metabolic pathway and associated regulatory mechanisms in these responses, seedlings were subjected to four nitrogen concentrations (N0, N6, N36, and N60: 0, 6, 36, and 60 mmol·L nitrogen, respectively). The seedling leaf transcriptome was analyzed by high-throughput sequencing (Illumina HiSeq 4000), and 332,420 transcripts and 276,423 unigenes were identified. The numbers of differentially expressed genes (DEGs) were 4052 in N0 vs.

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Phagocytosis of macrophages constitutes a powerful barrier to innate immunity. Differences in the phagocytic function of macrophages among chicken breeds have rarely been reported, and the molecular mechanisms underlying phagocytosis remain poorly understood. This study compared functional difference of macrophages in Dagu chickens, originated in Zhuanghe, Liaoning Province, China, and Wenchang chickens, originated from Hainan Island in the South China Sea, and explored the potential molecular mechanisms by integrated analysis of mRNA expression profiles of macrophages and whole genome sequencing.

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Quantification of leukocyte profiles is among the simplest measures of animal immune function. However, the relationship between H/L ratio and innate immunity and the measure's utility as an index for heterophil function remains to be analyzed. Variants associated with H/L ratio were fine-mapped based on the resequencing of 249 chickens of different generations and an F2 segregating population generated by crossing selection and control lines.

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Background: Previous studies have found qualitative structural and functional brain changes in major depressive disorder (MDD) patients. However, most studies ignored the complementarity of multisequence MRI neuroimaging features and cannot determine accurate biomarkers.

Purpose: To evaluate machine-learning models combined with multisequence MRI neuroimaging features to diagnose patients with MDD.

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With the development and wider application of meta-heuristic optimization algorithms, researchers increasingly apply them to threshold optimization of multi-level image segmentation. This paper explores the performance and effects of Capuchin Search Algorithm (CAPSA) in threshold optimization. To solve problems of uneven distribution in the initial population of Capuchin Search Algorithm, low levels of global search performance and premature falling into local optima, this paper proposes an improved Capuchin Search Algorithm (ICAPSA) through a multi-strategy approach.

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Background: Characterization of the dynamics of functional brain network has gained increased attention in the study of depression. However, most studies have focused on single temporal dimension, while ignoring spatial dimensional information, hampering the discovery of validated biomarkers for depression.

Purpose: To integrate temporal and spatial functional MRI variability features of dynamic brain network in machine-learning techniques to distinguish patients with major depressive disorder (MDD) from healthy controls (HCs).

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serovar Typhimurium (ST) is a food-borne pathogen that can infect animals and humans. It is currently the most common bacterial pathogen that negatively affects the poultry industry. Although different chicken breeds have been observed to exhibit diverse resistance to ST infection, the underlying genetic mechanisms remain unclear and the genes involved in this differential disease resistance need to be identified.

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Runs of homozygosity (ROHs) has become an effective method for analysing inbreeding in livestock populations. Moreover, ROHs is well-suited to detect signatures of selection via ROH islands. This study aimed to investigate the occurrence and distribution of ROHs, compare the genomic inbreeding coefficients and identify the genomic regions with high ROH frequencies in different Beijing-You chicken (BY) populations, including a random conservation population (BY_R), a pedigree conservation population (BY_P), and a commercial population obtained from the market (BY_C).

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