Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma.

Background: Increasing evidence has indicated that pyroptosis could regulate the tumor immune microenvironment (TIME) to affect the tumor development. As a highly immunogenic tumor, clear cell renal cell carcinoma (ccRCC) can benefit from immunotherapy, but related research on pyroptosis in the TIME of ccRCC is still deficient.

Methods: Available data derived from TCGA and GEO databases were analyzed to identify the different expression profiles of pyroptosis in ccRCC and normal tissues, and the correlation of pyroptosis regulators with TIME was evaluated in ccRCC.

A Novel Assessment Model Based on Molecular Subtypes of Hypoxia-Related LncRNAs for Prognosis of Bladder Cancer.

Hypoxia is a common feature in various tumors that regulates aggressiveness. Previous studies have demonstrated that some dysregulated long non-coding RNAs (lncRNAs) are correlated with tumor progression, including bladder cancer (BCa). However, the prognostic effect of hypoxia-related lncRNAs (HRLs) and their clinical relevance, as well as their regulatory effect on the tumor immune microenvironment, are largely unknown in BCa.

Study on the Synthesis of Castor Oil-Based Plasticizer and the Properties of Plasticized Nitrile Rubber.

A series of new environment-friendly plasticizers was synthesized from castor oil and used to plasticize nitrile rubber (NBR). The test results showed that tensile strength, elongation at break, and tear strength of NBR vulcanizates plasticized by castor oil-based plasticizers were found to be better than that of dioctyl phthalate (DOP). The aging test taken demonstrated that the castor oil-based plasticizers could improve the hot air and oil aging resistance of NBR vulcanizates.

Role of the Oxethyl Unit in the Structure of Vegetable Oil-Based Plasticizer for PVC: An Efficient Strategy to Enhance Compatibility and Plasticization.

Developing vegetable oil-derived primary plasticizers for poly(vinyl chloride) (PVC) is still a challenge because of their insufficient compatibility. As described in this work, we report the synthesis of plasticizers through the esterification of polyethylene glycol methyl ether and dimer acid, in which dimer acid is renewable material prepared via a two-step reaction (1) the hydrolysis of fatty acids from soybean oil at 70 °C and (2) subsequent Diels-Alder reaction at 250 °C. The resulting plasticizers, dimer acid-derived polyethylene glycol methyl ether esters (DA-2n, 2n = 2, 4, 6 or 8 referring to the number of oxethyl units per molecule), were blended with PVC.

Synthesis and properties of castor oil based plasticizers.

A series of environment-friendly plasticizers has been synthesized from castor oil through a mild esterification/epoxidation reaction. The modified epoxy acetylated castor oil (EACO) can plastify poly(vinyl chloride) (PVC) efficiently, even better than the commercial plasticizers dioctyl terephthalate (DOTP) and epoxidized soybean oil (ESO), in terms of in tensile strength, migration stability, solvent extraction stability and thermal stability. Specifically, the tensile strength and elongation at break of a PVC sample plastified by epoxy acetylated castor oil (EACO) were 18.