Two AIE-Ligand-Based 2-D Luminescent Metal-Organic Frameworks as Fe Sensors.

The design and synthesis of high-performance sensors are very important but remain great challenges. In this work, a new aggregation-induced-emission (AIE) molecule 4,4'-(((9-fluoren-9-ylidene)methylene)bis(4,1-phenylene))dipyridine () was successfully synthesized and first developed as a functional ligand to construct two isomorphic metal-organic frameworks (MOFs) [M()(OBBA)] [M = Cd (), Co (); HOBBA = 4,4'-oxybisbenzoic acid]. They adopt [M(COO)] flywheel clusters, OBBA bridges, and terminal ligands as building units to form isomorphic 2-D networks with Lewis base active cites (uncoordinated pyridyl N).

Perspective on fluorescence cell imaging with ionophore-based ion-selective nano-optodes.

Inorganic ions are ubiquitous in all kinds of cells with highly dynamic spatial and temporal distribution. Taking advantage of different types of fluorescent probes, fluorescence microscopic imaging and quantitative analysis of ion concentrations in cells have rapidly advanced. A family of fluorescent nanoprobes based on ionophores has emerged in recent years with the potential to establish a unique platform for the analysis of common biological ions including Na, K, Ca, Cl, and so on.

Phase transfer of fatty acids into ultrasmall nanospheres for colorimetric detection of lipase and albumin.

Colorimetric detection of fatty acids during biological interactions is extremely difficult since they are optically silent. Here, fatty acids are found to function as ion-exchangers in ultrasmall polymeric nanospheres to facilitate the protonation of chromoionophores, causing a vivid color change between red and blue. With an excellent detection limit of 1.

Ruthenium bipyridine complexes as electrochemiluminescent transducers for ionophore-based ion-selective detection.

We report here a method to determine target ion concentrations (with Na as a model) based on ionophores and electrochemiluminescence (ECL). Ruthenium bipyridine complexes were released from thin polymeric films (plasticized poly(vinyl chloride) also containing a sodium ionophore) into the sample solution following an explicit ion-exchange process (between Na and the ruthenium complex). Two signal transducers, tris(2,2'-(pCF)bipyridine)ruthenium(II) (Ru(p-CF-bpy)) and tris(2,2'-bipyridyl)dichlororuthenium(II) (Ru(bpy)), were examined using the sensing film, with the latter providing a more sensitive detection range ( 1 to 100 μM) than that of the more hydrophobic one (0.

Rapid Equilibrated Colorimetric Detection of Protamine and Heparin: Recognition at the Nanoscale Liquid-Liquid Interface.

Demand for rapid quantitation of polyions such as heparin and protamine are ever growing. Previous paper-based and polymeric optical and electrochemical sensing devices required more than several hours for signal stabilization. Therefore, signals were acquired with fixed sample exposure time modes, which was time-consuming and technically demanding.

Downregulation of microRNA-145 promotes epithelial-mesenchymal transition via regulating Snail in osteosarcoma.

Metastasis is the principal cause of cancer death and occurs through multiple, complex processes. Epithelial to mesenchymal transition (EMT) is an important process during embryonic development and has also been hypothesized to exhibit a significant role in cancer cell invasion and metastasis. MicroRNAs (miRNAs) are a class of widespread noncoding RNAs.

[Early microsurgical treatment of upper obstetrical brachial plexus injury].

Objective: To search for the operation timing and methods for obstetrical brachial plexus injury (OBPI).

Methods: Thirty-two children with upper OBPI were treated by microsurgical procedure from October 1997 to April 2001. The average age of patients was 10 months, ranged from 3 months to 24 months; of them, 19 were below 6 months while 13 were over 6 months.