Publications by authors named "Qingguo Li"

Purpose: To explore the risk factors of delirium in patients with stroke and develop a nomogram model to predict the occurrence of delirium.

Methods: Convenience sampling was used to select 502 patients with stroke admitted to a tertiary hospital with a neurology specialty in Tianjin from December 2023 to June 2024, who were categorized into the delirium group (n=141) and the non-delirium group (n=361) using the ICU Patient Ambiguity of Consciousness Assessment Scale. We explored the independent risk factors for the occurrence of delirium through univariate and multifactorial logistic regression analyses, established a risk prediction model, developed a nomogram, and validated the model both internally and externally.

View Article and Find Full Text PDF

Peritoneal metastasis (PM) is common in colorectal cancer (CRC), yet its underlying mechanisms are poorly understood. Here, we explored the transcriptional profile of CRC, PM and adjacent tissues revealing key players that facilitate PM. Single-cell analysis of 48 matched samples from 12 patients revealed that remodeling of malignant cells and the tumor microenvironment promotes CRC progression and metastasis.

View Article and Find Full Text PDF

Background: The prognostic value of tumor regression grade (TRG) after neoadjuvant chemoradiotherapy for rectal cancer is inconsistent in the literature. Both TRG and post-therapy lymph node (ypN) status could reflect the efficacy of neoadjuvant therapy. Here, we explored whether TRG combined with ypN status could be a prognostic factor for MRI-based lymph node-positive (cN+) rectal cancer following neoadjuvant chemoradiotherapy.

View Article and Find Full Text PDF

Invasive pulmonary aspergillosis poses a significant threat to immunocompromised patients, characterized by high mortality rates. Posaconazole (PSZ), a second-generation triazole antifungal, exhibits broad-spectrum activity but suffers from limited pulmonary concentrations and notable systemic side effects when administered orally or intravenously. This study focuses on optimizing PSZ nanocrystals-agglomerated particles for dry powder inhalers (DPIs) to enhance solubility, dissolution rates, and pulmonary deposition, ultimately improving therapeutic efficacy while minimizing systemic adverse effects.

View Article and Find Full Text PDF

Background And Aim: The risk of developing a second primary malignancy differs among colorectal cancer patients in different age groups. This study aimed to investigate the differences in prognosis and clinicopathological features of patients with early-onset colorectal cancer and late-onset colorectal cancer who developed second primary malignancies.

Methods: The study included 15 489 patients who underwent surgery for colorectal cancer at Fudan University Shanghai Cancer Center between January 2008 and December 2018.

View Article and Find Full Text PDF

Objective:  This study aimed to determine the impact of symptom-to-surgery time on mortality in acute type A aortic dissection (ATAAD) patients, with and without malperfusion.

Methods:  A retrospective analysis of 288 ATAAD patients was conducted. Patients were separated into the early (≤10 h) and late (>10 h) groups by symptom-to-surgery time.

View Article and Find Full Text PDF

Minimally invasive blood-contacting interventional devices are increasingly used to treat cardiovascular diseases. However, the risk of device-related thrombosis remains a significant concern, particularly the formation of cycling thrombi, which pose life-threatening risks. To better understand the interactions between these devices and blood, the initial stages of coagulation contact activation on extrinsic surfaces are investigated.

View Article and Find Full Text PDF

Colorectal cancer (CRC) is a prevalent malignant tumor worldwide, leading to significant morbidity and disease burden. Diagnostic indicators and treatment objectives for CRC are urgently needed. This study demonstrates that GPR37, a GPCR receptor, is highly expressed in CRC.

View Article and Find Full Text PDF
Article Synopsis
  • * Using two datasets, researchers found 23 differentially expressed genes and classified them into two disease subtypes, revealing that one subtype had a significantly worse prognosis than the other.
  • * The study established a prognostic risk score model with 10 key genes, which could be potential biomarkers for predicting patient outcomes in medulloblastoma.
View Article and Find Full Text PDF

Background: To evaluate the clinical value of serum CEA levels and their implications on the diagnostic value of the conventional TNM staging system in the oldest-old patients with colorectal cancer (CRC).

Methods: The recruited subjects were colorectal cancer patients aged 85 and older. The cutoff value for normal CEA level is 5 ng/mL.

View Article and Find Full Text PDF

Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective properties. However, the poor water solubility of OBB hinders its release and absorption thus resulting in low bioavailability. To overcome these drawbacks of OBB, amorphous spray-dried powders (ASDs) of OBB were formulated.

View Article and Find Full Text PDF

Aim: Admission systolic blood pressure is a significant predictor of in-hospital mortality in patients with acute type A aortic dissection (ATAAD). While previous studies have focussed on recording the highest blood pressure value from both arms, this study aimed to evaluate the associations between blood pressure in bilateral arms and in-hospital mortality.

Methods: Data were analysed from 262 patients with ATAAD treated at a single centre.

View Article and Find Full Text PDF

Background: While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood.

Methods: We conducted cell proliferation assays on CRC cells with or without depletion of squalene epoxidase (SQLE), with or without 5-fluorouracil (5-FU) treatment. Additionally, a xenograft mouse model was utilized to explore the impact of SQLE on the chemosensitivity of CRC to 5-FU.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how type 2 diabetes mellitus (T2DM) affects the prognosis of colorectal cancer (CRC) by analyzing data from 312 patients treated between 2012 and 2018, dividing them into comorbidity and non-comorbidity groups based on T2DM presence.
  • Findings indicate that the 5-year overall survival rate is significantly lower for CRC patients with T2DM (82.23%) compared to those without it (90.32%), highlighting the increased risk of death associated with the comorbidity.
  • Additional analyses show that poor blood glucose control and other factors, such as BMI and cancer stage, significantly impact survival outcomes, and a predictive nomogram model was created to assess the
View Article and Find Full Text PDF

Objective: With an aging population and advancements in imaging, recurrence of thoracic aortic dissection is becoming more common.

Methods: All patients enrolled in the International Registry of Aortic Dissection from 1996 to 2023 with type A and type B acute aortic dissection were identified. Among them, initial dissection and recurrent dissection were discerned.

View Article and Find Full Text PDF

Supercritical anti-solvent fluidized bed (SAS-FB) coating technology has the advantages of reducing particle size, preventing high surface energy particle aggregation, improving the dissolution performance and bioavailability of insoluble drugs. The poor solubility of Biopharmaceutics Classification System (BCS) class IV drugs poses challenges in achieving optimal bioavailability. Numerous anti-cancer drugs including paclitaxel (PTX) belong to the BCS class IV, hindering their therapeutic efficacy.

View Article and Find Full Text PDF

Approximately 20% of colorectal cancer (CRC) patients are first diagnosed with metastatic colorectal cancer (mCRC) because they develop symptoms at an advanced stage. Despite advancements in treatment, patients with metastatic disease still experience inferior survival rates. Our objective is to investigate the association between long noncoding RNAs (lncRNAs) and prognosis and to explore their role in mCRC.

View Article and Find Full Text PDF

While previous studies have indicated the involvement of Isthmin 1 (ISM1), a secreted protein, in cancer development, the precise mechanisms have remained elusive. In this study, we unveiled that ISM1 is significantly overexpressed in both the blood and tissue samples of colorectal cancer (CRC) patients, correlating with their poor prognosis. Functional experiments demonstrated that enforced ISM1 expression significantly enhances CRC proliferation, migration, invasion and tumor growth.

View Article and Find Full Text PDF
Article Synopsis
  • * Key findings indicate significant differences in four specific MRI features between CSH and non-CSH cases, particularly emphasizing the importance of the cavernous sinus swelling and extrusion sign as a primary diagnostic tool.
  • * The research concludes that using a combination of specific imaging features can enhance the accuracy of diagnosing CSH, achieving high sensitivity (94.44%) and specificity (100%).
View Article and Find Full Text PDF
Article Synopsis
  • * The lncRNA KB-1460A1.5 functions as a tumor suppressor by promoting ferroptosis in glioma cells, enhancing their sensitivity to ferroptosis inducers like RSL3.
  • * The study indicates that KB-1460A1.5 reduces certain fatty acid levels and inhibits a specific signaling pathway, leading to decreased tumor growth in animal models, suggesting its potential as a therapeutic target.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates a modified, minimally invasive selective dorsal rhizotomy (SDR) procedure aimed at treating spastic paralysis in adult patients, which is associated with fewer spinal deformities.
  • In an analysis involving 8 adult patients, the surgery involved resecting specific spinal structures while monitoring motor and sensory roots for safety, leading to significant improvements in muscle spasm and joint movement.
  • Results showed that all patients experienced positive outcomes without any complications such as persistent pain or spinal deformities, indicating the effectiveness of the new surgical approach and monitoring method.
View Article and Find Full Text PDF

Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis, while the underlying mechanism remains elusive. Here, we report that the non-canonical stimulator of interferon genes (STING)-PKR-like ER kinase (PERK) pathway was significantly activated in both human and mice atherosclerotic arteries. Typically, STING activation leads to the activation of interferon regulatory factor 3 (IRF3) and nuclear factor-kappa B (NF-B)/p65, thereby facilitating signals and inflammation.

View Article and Find Full Text PDF

The supercritical antisolvent-fluidized bed coating process (SAS-FB) shows great potential as a technique to manufacture dry powder inhaler (DPI) that incorporate nanodrugs onto micronized matrix particles, capitalizing on the merits of both nanoparticle and pulmonary delivery. In this study, naringin (NAR), a pharmacologically active flavonoid with low solubility and in vivo degradation issues, was utilized as a model active pharmaceutical ingredient to construct nanomedicine-based DPI through SAS-FB. It is showed that processed NAR exhibited a near-spherical shape and an amorphous structure with an average size of around 130 nm.

View Article and Find Full Text PDF

Background: Low anterior resection syndrome (LARS) is a series of bowel dysfunction symptoms, including altered bowel frequency, irregular bowel rhythms, fecal incontinence, and constipation. LARS occurs in 80% of patients undergoing sphincter-preserving surgery, affecting patients' quality of life along with social avoidance. Different measurements and treatments have been raised to deal with LARS, but no systematic standard has been developed.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session59jva9oa5n68mrcbn2b53k8qfpd9blkk): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once