Publications by authors named "Qinggui Ren"
Article Synopsis
- A high sucrose diet during pregnancy can have significant long-term effects on vascular health in offspring, particularly impacting pulmonary artery function.
- Pregnant rats given a high sucrose solution showed altered vascular structure and increased vasoconstriction in their adult offspring's pulmonary arteries.
- The study indicates that changes in specific gene expressions related to melatonin receptors may play a more crucial role in vascular issues than previously thought, instead of the expected protein kinase C signaling pathways.
Article Synopsis
- The study investigates the impact of a high-sucrose diet (HS) during pregnancy on the vascular health of offspring, specifically looking at renal interlobar arteries (RIA) in rats.
- Pregnant rats were either given normal water or a 20% high-sucrose solution, resulting in noticeable vascular damage and increased vasoconstriction responses in the offspring's arteries.
- The findings suggest that maternal HS affects vascular function through mechanisms involving reactive oxygen species (ROS) and the Akt signaling pathway, linked to reduced expression of the retinoid X receptor gamma (RXRg), which interacts with PPARγ.
Scope: The fetal programming in response to over-nutrition during pregnancy is involved in pathogenesis of cardiovascular diseases later in life. The authors' previous work reported that prenatal high-sucrose (HS) diet impaired functions of large-conductance Ca -activated K channels (BK) in mesenteric arteries in the adolescent offspring rats. This study determines whether prenatal HS has a long-term impact on resistance vasculature in the aged offspring rats.
View Article and Find Full Text PDFThe clinical value and biological function of PTTG1 in colorectal cancer.
Biomed Pharmacother
May 2017
Pituitary tumor transforming gene-1 (PTTG1) has been suggested to serve as an oncogene in several types of human tumors, but little is known about the biological function of PTTG1 in colorectal cancer. PTTG1 mRNA and protein expressions in colorectal cancer tissues and cell lines were measured by qRT-PCR, western blot or immunohistochemistry. The association between PTTG1 protein expression and clinicopathological features was analyzed.
View Article and Find Full Text PDFBackground: Obesity is an independent risk factor of development and progression of chronic kidney disease (CKD). Data on the benefits of bariatric surgery in obese patients with impaired kidney function have been conflicting.
Objective: To explore whether there is improvement in glomerular filtration rate (GFR), proteinuria or albuminuria after bariatric surgery.
This case-control study compared the effectiveness and safety of transanal pull-through procedure (TPP) with delayed or immediate coloanal anastomosis (CAA) for anus-preserving curative resection of lower rectal cancer. Lower rectal cancer patients (n = 128) were hospitalized between January 2003 and December 2013 for elective anus-preserving curative resection through a TPP with delayed (n = 72) or immediate (n = 56) CAA. Main outcome measures including surgical safety, resection radicality, and defecation function were assessed.
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