Publications by authors named "Qingfeng Xia"

Traditional medical image sensors face multiple challenges. First, these sensors typically rely on large amounts of labeled data, which are time-consuming and costly to obtain. Second, when the data volume and image size are large, traditional sensors have limited computational power, making it difficult to effectively train and infer models.

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Fast and effective algorithms for deep learning on 3D shapes are keys to innovate mechanical and electronic engineering design workflow. In this paper, an efficient 3D shape to 2D images projection algorithm and a shallow 2.5D convolutional neural network architecture is proposed.

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Selective laser melting (SLM) process was optimized in this work using multi-objectives genetic algorithm. Process parameters involved in the printing process have an obvious impact on the quality of the printed parts. As the relationship between process parameters and the quality of different parts are complex, it is quite essential to study the effect of process parameter combination.

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The development of high-performance probes that can visualize and track the dynamic changes of lysosomes is very important for the in-depth study of lysosomes. Herein, we report that a dicyanoisophorone-based probe (named ) can be used for high-fidelity imaging of lysosomes and lysosomal dynamics. can be easily prepared and shows strong far-red to near-infrared emissions centered at 653 nm in water with a huge Stokes shift (224 nm), high quantum yield (Φ = 0.

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Lysosomes are important subcellular organelles with acidic pH. The change of lysosomal pH can affect the normal function and activity of cells. To conveniently detect and visualize lysosomal pH changes, we designed herein a novel fluorescent probe NIR-Rh-LysopH.

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Article Synopsis
  • CORM-3 is a water-soluble carbon monoxide-releasing molecule used for studying the physiological effects of CO in living systems and can act as a therapeutic drug.
  • Researchers developed a near-infrared fluorescent probe that effectively detects CORM-3 in living cells, utilizing a 4-nitrobenzyl group to trap the molecule and release a fluorescent marker, QCy-7.
  • This probe demonstrates good water solubility, rapid and selective response to CORM-3, low cytotoxicity, and the ability to perform bioimaging in live cells and mice, making it a valuable tool for tracking CORM-3.
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Because of the biological importance of CO, the development of effective probes for the detection of CO in living systems is of great significance. In particular, near-infrared (NIR) fluorescence probes with good water solubility and large Stokes shift are indispensable tools for CO detection in vivo. However, such tools are extremely scarce.

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Article Synopsis
  • Hypochlorous acid (HClO) is crucial in various physiological processes, and abnormal levels are linked to diseases like inflammation and cancer.
  • A new probe called DDAO-ClO was developed to detect HClO through a specific reaction that allows for rapid colorimetric and near-infrared fluorescence responses.
  • DDAO-ClO demonstrated high sensitivity and fast response times in vitro, and it successfully imaged HClO in living cells and animals, revealing increased HClO production in injured liver tissues.
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The known action of Cu, Zn superoxide dismutase (Cu(2)Zn(2)SOD) that converts O(2)(-) to O(2) and H(2)O(2) plays a crucial role in protecting cells from toxicity of oxidative stress. However, the overproduction of Cu(2)Zn(2)SOD does not result in increased protection but rather creates a variety of unfavorable effects, suggesting that too much Cu(2)Zn(2)SOD may be injurious to the cells. The present study examined the DNA cleavage activity mediated by a Cu(n)SOD that contains 1-4 copper ions, in order to obtain an insight into the aberrant copper-mediated oxidative chemistry in the enzyme.

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