Publications by authors named "Qingcong Kong"
Article Synopsis
- MRI radiomics is being studied to classify breast cancer based on HER2 expression levels (HER2-zero, HER2-low, HER2-positive), but understanding how predictions are made is still limited.
- Researchers developed machine-learning models using multiparametric MRI data from 737 breast cancer patients to differentiate between HER2 expression levels, employing SHAP analysis for interpretability.
- Model performance showed promise, particularly with the combined model achieving an AUC of 0.762 for task 1, and SHAP analysis highlighted the significance of early-phase dynamic contrast-enhanced imaging features in the predictions.
Article Synopsis
- The study aimed to see if changes in multiparametric MRI can predict how well HER2-positive breast cancer patients respond to neoadjuvant chemotherapy (NAC) early on, and to develop quantitative models based on these MRI features.
- A total of 164 patients underwent MRI before and after two cycles of NAC, assessing various MRI characteristics to determine their impact on the likelihood of achieving a pathological complete response (pCR).
- The research identified key predictive factors, including changes in tumor size and MRI values, leading to two predictive models: one based on clinicopathological data and another combining these features, both showing strong predictive capabilities across different patient groups.*
Objectives: Triple-negative breast cancer (TNBC) is a heterogeneous disease, and different histological subtypes of TNBC have different clinicopathological features and prognoses. Therefore, this study aimed to establish a nomogram model to predict the histological heterogeneity of TNBC: including Metaplastic Carcinoma (MC) and Non-Metaplastic Carcinoma (NMC).
Methods: We evaluated 117 patients who had pathologically confirmed TNBC between November 2016 and December 2020 and collected preoperative multiparameter MRI and clinicopathological data.
Objective: To investigate the efficacy and safety of clinical, magnetic resonance imaging (MRI) changes in active ankylosing spondylitis (AS) patients with etanercept and celecoxib alone/combined treatment.
Methods: A randomized controlled trial was conducted in three medical centers in China. Adult AS patients with BASDAI ≥4 or ASDAS ≥2.
Background: The monitoring of immunotherapies is still based on changes in the tumor size in imaging, with a long evaluation period and low sensitivity.
Purpose: To investigate the effectiveness of diffusion kurtosis imaging (DKI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in assessing the therapeutic efficacy of anti-programmed death-1 (PD-1) therapy in a mouse triple negative breast cancer (TNBC) model.
Study Type: Prospective.
Objective: To study the diagnostic performance of chemical shift-encoded MRI (CSE-MRI) in the diagnosis of axial spondyloarthritis (axSpA).
Methods: CSE-MRI images were acquired for consecutive patients complaining of back pain as well as healthy volunteers. Proton density fat fraction (PDFF) values were measured independently by two readers.
Objective: To systematically investigate the effect of imaging features at different DCE-MRI phases to optimise a radiomics model based on DCE-MRI for the prediction of tumour-infiltrating lymphocyte (TIL) levels in breast cancer.
Materials And Methods: This study retrospectively collected 133 patients with pathologically proven breast cancer, including 73 patients with low TIL levels and 60 patients with high TIL levels. The volumes of breast cancer lesions were manually delineated on T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and each phase of DCE-MRI, followed by 6250 quantitative feature extractions.
Article Synopsis
- The study aims to assess how the apparent diffusion coefficient (ADC) histogram can differentiate between benign and malignant breast lesions, as well as distinguish between various subtypes of breast cancer and analyze its correlation with Ki-67 expression, a marker for tumor proliferation.
- A total of 189 patients were included, with significant differences in age, lesion size, and ADC histogram parameters found between benign and malignant lesions, highlighting the effectiveness of median and mean ADC values for classification.
- Results showed that specific ADC values could determine HER-2 and hormone receptor statuses, and certain histogram parameters like entropy and skewness had the potential to classify tumors based on Ki-67 expression levels.
Objective: The effect of lumbar traction on low back pain (LBP) patients is controversial. Our study aims to assess changes in the intervertebral disc water content after lumbar traction using T2 mapping and explore the correlation between changes in the T2 value and Oswestry Disability Index (ODI)/visual analogue scale (VAS) score.
Design: Lumbar spine magnetic resonance imaging was performed, and the ODI/VAS scores were recorded in all 48 patients.
Article Synopsis
- The study investigates the potential of apparent diffusion coefficient (ADC) metrics from MRI to evaluate tumor-infiltrating lymphocyte (TIL) levels in breast cancer patients, focusing on different molecular subtypes of the disease.
- The research included 114 breast cancer patients who underwent specialized MRI imaging to assess various ADC parameters, discovering significant differences in ADC values and other statistical measures between groups with low and high TIL levels.
- The results indicate a correlation between lower ADC values, particularly in the luminal subtype, and lower TIL levels, with Ki-67 expression also showing significance, suggesting ADC metrics could serve as useful indicators in breast cancer assessments.
Purpose: To investigate whether whole-tumor apparent diffusion coefficient (ADC) histogram analysis could be helpful to evaluate breast phyllode tumor (PT) grades.
Materials And Methods: This institutional review board-approved retrospective study included 56 PTs (23 benign lesions, 22 borderline lesions, and 11 malignant lesions) from August 2011 to November 2017. MRI was performed using a 1.
Background: Given the high mortality rate and unclear pathogenesis for liver cancer, investigation of its molecular mechanisms is essential. We focused on the long non-coding RNA (lncRNA) MIR4435-2HG, which was recently reported to be oncogenic in lung cancer and the microRNA miRNA-487a, which has been reported to be oncogenic in hepatocellular carcinoma (HCC). Our aim was to determine if the former has a role in HCC, and to further validate the role of the latter.
View Article and Find Full Text PDFIncreasing evidence highlights the important role of XIST, a long non-coding RNA (lncRNA), in the regulation of multiple cancers. However, the underlying mechanism of XIST in human hepatocellular carcinoma (HCC) still remains to be explored. Herein, intended to investigate the functional role of XIST in HCC initiation and progression.
View Article and Find Full Text PDFPurpose To assess the diagnostic accuracy of magnetic resonance (MR) imaging for differentiating stage T1 or lower tumors from stage T2 or higher tumors and to analyze the influence of different imaging protocols in patients with bladder cancer. Materials and Methods A systematic literature search for original diagnostic studies was performed in PubMed, Medline, the Cochrane Library, and Web of Science. The methodologic quality of each study was evaluated by two independent reviewers who used the Quality Assessment of Diagnostic Accuracy Studies 2 tool.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess how effective whole-lesion histogram apparent diffusion coefficient (ADC) values are in understanding the heterogeneity of mucinous breast carcinoma (MBC) and identifying which ADC metrics could help distinguish MBC subtypes.
- A total of 52 MBC patients were analyzed, comparing pure MBC (PMBC) and mixed MBC (MMBC) case groups using diffusion-weighted imaging and various ADC parameters.
- Results showed that certain ADC values were significantly higher in the PMBC group compared to MMBC and that specific percentiles were especially effective in differentiating between PMBC subtypes, indicating that ADC histogram analysis could be a valuable tool in conjunction with traditional MRI.
Objectives: To summarize the characteristics of backfill in patients with axial spondyloarthritis (SpA) and patients with non-specific back pain (NSBP) and healthy controls, and to assess the value of backfill in diagnosing axial SpA.
Methods: Three readers blinded recorded backfill seen on T1SE MRI scans from 647 subjects: 297 patients with ankylosing spondylitis (AS), 126 patients with non-radiographic axial SpA (nr-axSpA), 147 patients with NSBP, and 77 healthy controls. The SPARCC SIJ Structural Score (SSS) method was used to assess backfill.
Objective: To explore the clinical characteristics and possible pathological mechanisms of vertigo due to enlarged vestibule with lateral semicircular canal dysplasia.
Methods: A retrospective review was conducted for 5 cases of peripheral vertigo due to enlarged vestibule with lateral semicircular canal dysplasia. Their characteristics of medical history, precipitating factors, course of vertigo, auditory tests, vestibular tests and imaging examine results were analyzed.
[Vertigo due to neurovascular cross-compression: diagnosis and treatment].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
August 2010
Objective: To explore the clinical characteristics, pathological mechanism, diagnose, differential diagnosis and the treatment of vascular compressive vestibular neuropathy.
Method: The authors retrospectively studied 2 cases of vascular compressive vestibular neuropathy about clinical characteristics, auditory tests, vestibular tests and imaging examine results, pharmacotherapy results and reviewed the related documents.
Result: There were some common clinical characteristics: (1) Vertigo and disequilibrium could be elicited by any physical activity and head movement and abated with complete bed rest; (2) Symptoms and signs can't be improved by vestibular suppressant medications; (3) When taken Dix-Hallpike test, true vertigo or a spinning sensation appeared during head movement, when head skilled at any position,the symptoms disappeared; (4) The suffering lateral often showed high frequency sensorineural hearing loss ,the ABR of the suffering lateral showed prolonged inter wave latency of I-III wave; (5) Vestibular tests showed central lesion; (6) Occupying lesion can be ruled out by CT and MRI, MRI showed neurovascular compression of vestibular nerve; (7) Taking carbamazepine plus baclofen or only Tegretol orally can alleviate symptoms.
Objective: To investigate the prognostic value of proton magnetic resonance spectroscopy (1H-MRS) in the study of warm ischemia reperfusion injury to the regeneration of hepatic cells of the livers following their orthotopic transplantation in rats.
Methods: A rat orthotopic liver transplantation (OLT) model with warm ischemia, the experimental group, was established and the same was done with a control group but without warm ischemia of the livers. They were studied at 6 time points (6 hours, 1, 3, 7, 14, and 30 days after OLT).
[The application of spiral CT in diagnosing the otitis media with cholesteatoma].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2007
Objective: To discuss the application of spiral CT imaging of temporal bone in diagnosing the chronic otitis media with cholesteatoma.
Method: The clinical data and spiral CT manifestation of 104 cases of chronic otitis media with cholesteatoma were retrospectively analyzed. All the diagnoses were confirmed by operation and pathology.