Drug repositioning via Multi-view Representation Learning with Heterogeneous Graph Neural Network.

Exploring simple and efficient computational methods for drug repositioning has emerged as a popular and compelling topic in the realm of comprehensive drug development. The crux of this technology lies in identifying potential drug-disease associations, which can effectively mitigate the burdens caused by the exorbitant costs and lengthy periods of conventional drugs development. However, current computational drug repositioning methods face challenges in accurately predicting drug-disease associations.

Control of carbon dioxide exchange fluxes by rainfall and biological carbon pump in karst river-lake systems.

As an important component of inland water, the primary factors affecting the carbon cycle in karst river-lake systems require further investigation. In particular, the impacts of climatic factors and the biological carbon pump (BCP) on carbon dioxide (CO) exchange fluxes in karst rivers and lakes deserve considerable attention. Using quarterly sampling, field monitoring, and meteorological data collection, the spatiotemporal characteristics of CO exchange fluxes in Erhai Lake (a typical karst lake in Yunnan, SW China) and its inflow rivers were investigated and the primary influencing factors were analyzed.

Key Factors Affecting Mathematics Teachers' Well-Being and Stress Levels: An Extended Engagement Theory.

The mathematics teachers' profession often has many challenges. It also occupies important positions at the K-12 education level, in which mathematics knowledge is the basis of all scientific fields. This tends to cause high-stress levels and a negative effect on well-being.

In-situ growing of metal-organic frameworks on iron mesh as a recyclable remediation material for removing hexavalent chromium from groundwater.

The recovery and reuse of adsorbents is crucial for the effectiveness and sustainability of mitigation methods for groundwater pollution. Considering the difficulty in recovering powder materials and the low mechanical strength of membrane materials, we developed a sheet material with good recyclability and certain mechanical strength. In this study, an in situ synthesized MIL-100(Fe) film sample was produced by hydrothermal reaction using a commercially available iron mesh as the substrate.

Cooperative upconversion luminescence of Er in GdOS phosphor.

GdOS:Er crystals were prepared through high-temperature solid-state reaction method in vacuum, with the vacuum synthesis mechanism determined by thermal analysis. The crystal structure and upconversion luminescence properties were investigated respectively by XRD, TEM and spectrophotometer. Well crystallized GdOS:Er phosphors were prepared under 1000°C in vacuum with a certain excessive amount of sulfur content than stoichiometric.

Methane adsorption on porous nano-silica in the presence of water: An experimental and ab initio study.

This study investigated the effects of silanol groups and water content on methane adsorption on hydrophilic nano-silica H-380 through experiments and ab initio calculations. Fourier transform infrared (FTIR) spectroscopy was used to confirm the presence of silanol groups on the solid surface, and the pore size distribution between 0 and 40nm was determined using CO2 and N2 sorption experiments. Ab initio MP2 and complete basis set model (CBS-4) calculations were performed to optimize four different silica surfaces with and without silanol groups using different basis sets.

[Degradation mechanism of acid red B by cathodic oxidation].

Acid red B (ARB) solution with pH = 3 was electrolyzed in a two-chamber cell using Pt/C gas diffusion electrode (GDE) as cathode. The color and COD removal ratio in cathode chamber were 94.2% and 66.