Bodipy-Based Metal-Organic Frameworks Transformed in Solid States from 1D Chains to 2D Layer Structures as Efficient Visible Light Heterogeneous Photocatalysts for Forging C-B and C-C Bonds.

Boron dipyrromethene (also known as bodipy), as a class of versatile and robust fluorophores and a structural analogue of porphyrins, has received a great deal of interests in the field of light-harvesting and energy-transfer processes. However, the fabrication of bodipy monomers into metal-organic frameworks (MOFs) and the exploitation of their potential still lags behind the porphyrin MOFs. In this work, two bodipy-based MOFs, BMOF with 1D chain structure and BMOF with 2D layer structure, were assembled by using dicarboxyl-functionalized bodipy ligands.

A visible light/heat responsive covalent organic framework for highly efficient and switchable proton conductivity.

In recent years, covalent organic frameworks (COFs) have attracted enormous interest as a new generation of proton-exchange membranes, chemical sensors and electronic devices. However, to design high proton conductivity COFs, especially those with stimulus responsive performance remains a great challenge. Here, the first example of a light/heat switchable COF (COF-HNU9) has been synthesized by grafting a donor-acceptor Stenhouse adduct (DASA) within the channels of a β-ketoenamine-based COF.

Tailoring Multiple Sites of Metal-Organic Frameworks for Highly Efficient and Reversible Ammonia Adsorption.

The structural diversity and designability of metal-organic frameworks (MOFs) make these porous materials a strong candidate for NH uptake. However, to achieve a high NH capture capacity and good recyclability of MOFs at the same time remains a great challenge. Here, a multiple-site ligand screening strategy of MOFs is proposed for highly efficient and reversible NH uptake for the first time.

Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy.

Background: Recent studies have validated and confirmed the great potential of nanoscale metal-organic framework (NMOF) in the biomedical field, especially in improving the efficiency of cancer diagnosis and therapy. However, most previous studies only utilized either the metal cluster or the organic ligand of the NMOF for cancer treatments and merely reported limited theranostic functions, which may not be optimized. As a highly designable and easily functionalized material, prospective rational design offers a powerful way to extract the maximum benefit from NMOF for cancer theranostic applications.

Design and assembly of a chiral composite metal-organic framework for efficient asymmertric sequential transformation of alkenes to amino alcohols.

In this work, we report the successful construction of two chiral porous metal-metallosalan frameworks (1 and 2) by using dipyridylfunctionalized chiral Al(salen) and Mn(salen) separately, and then a composite crystal MOF 3 was constructed with 1 inside, which was encapsulated by 2 outside. The resulting composite crystal appeared to be highly enantioselective for the alkene epoxidation/epoxide aminolysis reactions with a maximum ee of 97%.

Chiral binary metal-organic frameworks for asymmetric sequential reactions.

Two chiral porous MOFs with precise and appropriate spatial arrangements of different metallosalen active sites are synthesized and used as efficient heterogeneous catalysts for asymmetric sequential alkene epoxidation/epoxide ring-opening reactions with enantioselectivity of up to 99%.

Chiral Covalent Organic Frameworks with High Chemical Stability for Heterogeneous Asymmetric Catalysis.

Covalent organic frameworks (COFs) featuring chirality, stability, and function are of both fundamental and practical interest, but are yet challenging to achieve. Here we reported the metal-directed synthesis of two chiral COFs (CCOFs) by imine-condensations of enantiopure 1,2-diaminocyclohexane with C-symmetric trisalicylaldehydes having one or zero 3-tert-butyl group. Powder X-ray diffraction and modeling studies, together with pore size distribution analysis demonstrate that the Zn(salen)-based CCOFs possess a two-dimensional hexagonal grid network with AA stacking.

Multivariate Metal-Organic Frameworks as Multifunctional Heterogeneous Asymmetric Catalysts for Sequential Reactions.

The search for versatile heterogeneous catalysts with multiple active sites for broad asymmetric transformations has long been of great interest, but it remains a formidable synthetic challenge. Here we demonstrate that multivariate metal-organic frameworks (MTV-MOFs) can be used as an excellent platform to engineer heterogeneous catalysts featuring multiple and cooperative active sites. An isostructural series of 2-fold interpenetrated MTV-MOFs that contain up to three different chiral metallosalen catalysts was constructed and used as efficient and recyclable heterogeneous catalysts for a variety of asymmetric sequential alkene epoxidation/epoxide ring-opening reactions.

Chiral Cu(salen)-Based Metal-Organic Framework for Heterogeneously Catalyzed Aziridination and Amination of Olefins.

A homochiral 3D porous metal-organic framework was assembled from a chiral dicarboxylic acid-functionalized Cu(salen)-based catalyst and could serve as an efficient heterogeneous catalyst for aziridination and allylic amination of olefins. Besides easy separation and reuse of the catalyst, the chiral framework confinement could impart substrate size selectivity, enhance catalyst activity, and induce product enantioselectivity.

A Cr(salen)-based metal-organic framework as a versatile catalyst for efficient asymmetric transformations.

A porous Cr(salen)-MOF can serve as an efficient and effective heterogeneous catalyst for a series of important asymmetric transformations including the Nazarov cyclization, aminolysis reaction, and Diels-Alder and hetero Diels-Alder reactions, resulting in comparable or superior diastereo- or enantioselectivity with respect to the corresponding homogeneous systems.

Direct and post-synthesis incorporation of chiral metallosalen catalysts into metal-organic frameworks for asymmetric organic transformations.

Two chiral porous metal-organic frameworks (MOFs) were constructed from [VO(salen)]-derived dicarboxylate and dipyridine bridging ligands. After oxidation of V(IV) to V(V) , they were found to be highly effective, recyclable, and reusable heterogeneous catalysts for the asymmetric cyanosilylation of aldehydes with up to 95 % ee. Solvent-assisted linker exchange (SALE) treatment of the pillared-layer MOF with [Cr(salen)Cl]- or [Al(salen)Cl]-derived dipyridine ligands led to the formation of mixed-linker metallosalen-based frameworks and incorporation of [Cr(salen)] enabled its use as a heterogeneous catalyst in the asymmetric epoxide ring-opening reaction.

[Glycometabolism of patients with depression at first episode].

Objective: To investigate glycometabolism of patients with depression at first episode.

Methods: Oral glucose tolerance test (OGTT) was performed in 100 patients with depression at first episode and 50 healthy subjects; the levels of fast blood plasma insulin were also measured.

Result: There were no statistically significant differences in fast blood plasma insulin levels and postprandial blood glucose levels at 0 h, 1 h and 3 h (P>0.

Multiple topological isomerism of three-connected networks in silver-based metal-organoboron frameworks.

Three 3D Ag-based metal-organoboron frameworks with unprecedented multiple topological isomerism of 3-connected networks were assembled and could control the release of silver ions in biocidal concentration in solution giving excellent antibacterial activities and durability against gram-negative bacteria and gram-positive human pathogens.