Association of Stress Defense System With Fine Particulate Matter Exposure: Mechanism Analysis and Application Prospects.

The association between the stress defense system and exposure to fine particulate matter (PM) is a hot topic in the field of environmental health. PM pollution is an increasingly serious issue, and its impact on health cannot be ignored. The stress defense system is an important biological mechanism for maintaining cell and internal environment homeostasis, playing a crucial role in PM-induced damage and diseases.

Expression of MMP-14 and its role in bone destruction in middle ear cholesteatoma: A prospective observational study.

Cholesteatoma is a noncancerous cystic lesion caused by an abnormal growth of keratinizing squamous epithelium which is invasive and capable of destroying structures. A prospective study on the expression of membrane type1-matrix metalloproteinases (MMP-14) and its related influencing factors in middle ear cholesteatoma was conducted to fully understand the pathogenesis of cholesteatoma in the molecular level. We examined the expression of MMP-14 by immunohistochemical staining 39 middle ear cholesteatoma specimens and 10 external auditory meatus epithelial cell specimens.

A zero-liquid-discharge scheme for vanadium extraction process by electrodialysis-based technology.

The sharp increase of demand for vanadium makes the treatment of the wastewater generated from its extraction process become an urgent problem. In this study, a hybrid process coupling the electrodialysis with the cooling crystallization is put forward for upgrading the conventional vanadium extraction process to zero discharge. Accordingly, the objective of this work lies in evaluating the feasibility of the proposed scheme on the basis of a systematic study on the influences of membrane types and operating parameters on the electrodialysis performance.

Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinoma.

Objective: Epstein-Barr virus (EBV) is a causative agent of nasopharyngeal carcinoma (NPC), and EBV gene expression is considered to be closely associated with the pathogenesis of NPC. Among EBV genes expressed in NPC, EBV-encoded non-polyadenylated RNAs, termed EBERs, are the most abundant transcripts of EBV in NPC. However, the role of EBERs still remains unclear.

[Malignant transformation of a human oral squamous cell carcinoma cell strain OSC-19 by EBV encoded small RNAs].

Objective: To observe the growth characteristics of the EBERs-transfected OSC (oral squamous carcinoma)-19 cells, through generated overexpression of EBERs in OSC-19 cells.

Method: EBERs fragment were amplified by PCR from EBV-positive NPC-KT cell DNA. Using molecular biologic technique, we constructed the EBERs-expressing plasmids, which contained, 4 or 10 tandem repeats of the EBERs.

Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the nuclear factor-kappa B signaling pathway in EBV-infected nasopharyngeal carcinoma cell line.

Background/objectives: Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic malignant tumor and is associated with Epstein-Barr virus (EBV) infection that exhibits type II latency. Angiogenesis is essential for tumor growth, invasion, and metastasis. Our previous studies have indicated that interleukin (IL)-8 was over-expressed in many NPC tissues and was found to be significantly correlated with angiogenesis by immunohistochemistry.