Glucose oxidase-driven self-accelerating drug release nanosystem based on metal-phenolic networks orchestrates tumor chemotherapy and ferroptosis-based therapy.

Nanocarriers responding to tumor microenvironment have been extensively exploited to improve the antitumor outcome of chemotherapeutic drugs. However, selectively and completely releasing drugs within the tumor remains a challenge, thereby limiting the therapeutic effect of drug delivery nanosystem. To tackle this challenge, a metal-phenolic networks (MPNs)-based nanosystem (F-MGD) showing the capability of self-accelerating drug release was originally fabricated in this study.

Characteristics and development of steepland gullies in the dry valleys of Southwest China.

In semi-arid and arid areas, gully erosion is one of the most destructive forms of erosion and causes serious land degradation and resource destruction. Steepland gullies are widely distributed in the dry valleys of southwest China, and their formation is one of the main causes of soil erosion and the destruction of sloping farmland in the region. Previous research on the development of steepland gullies is limited, and further study is needed.

BIRC5 facilitates cisplatin-chemoresistance in a mA-dependent manner in ovarian cancer.

Cisplatin-based chemotherapy is the standard treatment for metastatic ovarian cancer (OC). However, chemoresistance continues to pose significant clinical challenges. Recent research has highlighted the baculoviral inhibitor of the apoptosis protein repeat-containing 5 (BIRC5) as a member of the inhibitor of the apoptosis protein (IAP) family.

A Prognostic Signature for Colon Adenocarcinoma Patients Based on m6A-Related lncRNAs.

N6-methyladenosine (m6A) modification is a common epigenetic modification. It is reported that lncRNA can be regulated by m6A modification. Previous studies have shown that lncRNAs associated with m6A regulation (m6A-lncRNAs) serve as ideal prognostic biomarkers.

Hypoxia-induced miR-653 enhances colorectal cancer progression by targeting circSETD3/KLF6 axis.

The present work focused on exploring the role and underlying molecular mechanism of action of the non-coding RNA (miRNA/circRNA) in colorectal cancer (CRC). Here, we found that miR-653 was dramatically upregulated in CRC tissues and cells. CRC Patients with high miR-653 level possessed poor prognosis.

Influence of Topographic Factors on the Characteristics of Gully Systems in Mountainous Areas of Ningnan Dry-Hot Valley, SW China.

A gully system is an important indicator that reflects the development of regional topography and landforms, and topography is one of the most important factors affecting the development of gullies. However, at present, research on the impact of topography on the development of gully systems in the mountainous area of Ningnan dry-hot valley still needs to be strengthened. In order to study the characteristics of gullies and the influence of topography on the development of gully systems, based on both the visual interpretation of remote sensing images and field investigations, five topographic factors (elevation, slope gradient, aspect, relief, and dissection) were employed and three gully erosion indexes (gully length, density, and frequency) were calculated.

Molecular characterization of matrix metalloproteinase gene family across primates.

Deregulation of matrix metalloproteinases (MMPs) contributes considerably to cancers, psychiatric disorders, macular degeneration and bone diseases. The use of humans in the development of MMPs as prognostic biomarkers and therapeutic targets is complicated by many factors, while primate models can be useful alternatives for this purpose. Here, we performed genome-enabled identification of putative MMPs across primate species, and comprehensively investigated the genes.

LRG1 mediated by ATF3 promotes growth and angiogenesis of gastric cancer by regulating the SRC/STAT3/VEGFA pathway.

Background: Increasing evidence indicates that leucine-rich-alpha-2-glycoprotein 1 (LRG1) is associated with multiple malignancies, but whether it participates in gastric cancer (GC) angiogenesis remains unclear.

Methods: The expression levels of LRG1 were assessed in GC samples. Endothelial tube formation analysis, HUVEC migration assay, chorioallantoic membrane assay (CAM), and xenograft tumor model were used to investigate the effect of LRG1 on angiogenesis in gastric cancer.

A Multimodal Affinity Fusion Network for Predicting the Survival of Breast Cancer Patients.

Accurate survival prediction of breast cancer holds significant meaning for improving patient care. Approaches using multiple heterogeneous modalities such as gene expression, copy number alteration, and clinical data have showed significant advantages over those with only one modality for patient survival prediction. However, existing survival prediction methods tend to ignore the structured information between patients and multimodal data.

LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway.

Dysregulation of long noncoding RNA (lncRNA) is frequently involved in the progression and development of osteosarcoma. LncRNA RUSC1-AS1 is reported to be upregulated and acts as an oncogene in hepatocellular carcinoma, cervical cancer and breast cancer. However, its role in osteosarcoma has not been studied yet.

Identification of an autophagy-related gene signature for survival prediction in patients with cervical cancer.

Cervical cancer is one of the most common female malignancy that occurs worldwide and is reported to cause over 300,000 deaths in 2018. Autophagy controls the survival and death of cancerous cells by regulating the degradation process of cytoplasm and cellular organelle. In the present study, the differentially expressed autophagy-related genes (ARGs) between healthy and cancerous cervical tissues (squamous cell neoplasms) were obtained using data from GTEx and The Cancer Genome Atlas (TCGA) database.

Spatial differentiation of gully clusters based on the regional scale: an example from northeastern China.

Gully erosion represents a serious environmental threat around the world, but their spatial distribution law are unclear at the regional scale. To quantitatively characterize the spatial distribution model of gullies and determine the regularity of regional differentiation, this paper used spatial analyst and statistics method to study the spatial distribution of gullies in 34 sample areas of northeastern China based on interpretations of high-resolution remote sensing images. The results showed that the kernel density could quantitatively describe the continuous spatial clustering of gullies.

A novel signature of two long non-coding RNAs in BRCA mutant ovarian cancer to predict prognosis and efficiency of chemotherapy.

Background: In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gynecologic cancer in women worldwide.

Methods: Univariate Cox proportional-hazards and multivariate Cox regression analyses were used to identifying prognostic factors from data obtained from The Cancer Genome Atlas (TCGA) database. The area under the curve of the receiver operating characteristic curve was assessed, and the sensitivity and specificity of the prediction model were determined.

Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data.

Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancer in female worldwide. PIK3CA has been proven to be a strong prognostic biomarker in UCEC. Nevertheless, current studies have not investigated what effects PIK3CA had on tumor associated neutrophils (TANss).

The mechanical properties, microstructures and mechanism of carbon nanotube-reinforced oil well cement-based nanocomposites.

High performance cement-based nanocomposites were successfully fabricated through the use of oil well cement filled with multiwalled carbon nanotubes (MWCNTs) as reinforcements. The dispersibilities of four dispersing agents for the MWCNTs were investigated and compared. The dispersed morphologies and structural characteristics of the MWCNTs were analyzed TEM, FTIR and Raman spectroscopy studies.

Effect of Bifunctional Montmorillonite on the Thermal and Tribological Properties of Polystyrene/Montmorillonite Nanocomposites.

In this work, the effect of doubly functionalized montmorillonite (MMT) on the structure, morphology, thermal, and tribological characteristics of the resulting polystyrene (PS) nanocomposites was investigated. The modification of the MMT was performed using a cationic surfactant and an anionic surfactant or a silane coupling agent to increase the compatibility with PS matrix. The polystyrene/organo-montmorillonite (PS/OMMT) nanocomposite particles were prepared by soap-free emulsion polymerization.

Anion amphiphilic random copolymers and their performance as stabilizers for O/W nanoemulsions.

A series of anionic amphiphilic random copolymers with sodium p-styrene sulfonate and dodecyl methacrylate side chains were synthesized free radical polymerization and their properties in the formation and stabilization of nano-emulsions were investigated. Using poly(sodium p-styrene sulfonate)--poly(dodecyl methacrylate) and Brij 30 as a stabilizer to prepare nanoemulsions, we obtained small droplet size and unimodal distribution nanoemulsions by a low-energy phase inversion composition (PIC) method. The p(SSS)--p(LMA)-Brij 30 co-stabilized nanoemulsions show extraordinary long-term stability and heat resistance, there were almost no variations of droplet size after storing for 35 days and no phase inversion occurred when heating the temperature up to 90 °C.

Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system.

AbstractThe original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead.

An Efficient Feature Selection Strategy Based on Multiple Support Vector Machine Technology with Gene Expression Data.

The application of gene expression data to the diagnosis and classification of cancer has become a hot issue in the field of cancer classification. Gene expression data usually contains a large number of tumor-free data and has the characteristics of high dimensions. In order to select determinant genes related to breast cancer from the initial gene expression data, we propose a new feature selection method, namely, support vector machine based on recursive feature elimination and parameter optimization (SVM-RFE-PO).

Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system.

Background: Ovarian cancer stem cells (OCSCs) contribute to the poor prognosis of ovarian cancer. Involvement of the androgen receptor (AR) in the malignant behaviors of other tumors has been reported. However, whether AR associates with Nanog (a stem cell marker) and participates in OCSC functions remain unclear.

[Efficacy and safety of lactulose on the treatment of puerperal constipation].

Objective: To observe the therapeutic effects and security of oral lactulose solution on treatment of puerperal constipation.

Methods: A total of 200 patients with puerperal constipation who received regular antenatal cares from early pregnancy in our department and delivered in our hospital from January 2013 to October 2013, were randomly divided into two groups. The patients in control group (n = 100) received defecation habits training, diet management and drinking adequate water etc.

Effects of massage treatment combined with topical cactus and aloe on puerperal milk stasis.

Aim: Puerperal milk stasis is one of the most common puerperal complication that directly affects breastfeeding. Massage treatment with topical cactus and aloe for puerperal milk stasis might be a superior treatment, and it does not affect breastfeeding.

Methods: The intervention group was treated with massages with cactus and aloe cold compresses, and the control group was treated with massage treatment or cactus and aloe cold compresses alone.

Cancer-associated fibroblasts enhance the migration ability of ovarian cancer cells by increasing EZH2 expression.

The tumor microenvironment is thought to affect malignant transformation and tumor progression. The histone methyltransferase, enhancer of zeste homologue 2 (EZH2), has recently been suggested to play a critical role in the tumorigenesis of several types of human cancer. The aim of this study was to investigate the effects of cancer-associated fibroblasts (CAFs) on the expression of EZH2 and the migration ability of ovarian cancer cells, in order to explore the link between the tumor microenvironment and epigenetic regulation.

Glyoxylate reductase/hydroxypyruvate reductase: a novel prognostic marker for hepatocellular carcinoma patients after curative resection.

Objective: Glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a key enzyme in the glyoxylate cycle. Its deficiency causes primary hyperoxaluria type 2. We first noticed that GRHPR was also lost in human hepatocellular carcinoma (HCC) and proliferative HCC cells.