Publications by authors named "Qingchi Zhang"
Transl Pediatr
April 2024
Article Synopsis
- Infantile fibrosarcoma (IFS) is the most common soft tissue sarcoma in infants under 1 year, characterized by rapid growth and a complicated tumor microenvironment, presenting challenges in treatment without specific diagnostic markers.
- The study utilized single-cell RNA sequencing on fresh IFS samples from four patients to analyze the tumor's cellular makeup, revealing 14 distinct cell populations and identifying novel potential markers for diagnosis and therapy.
- Findings highlighted the presence of cancer stem cell subtypes and significant communication between endothelial cells and macrophages in the tumor microenvironment, which may promote tumor growth and offer new avenues for therapeutic intervention.
