Ginsenoside Rk3 Inhibits the Extramedullary Infiltration of Acute Monocytic Leukemia Cell via miR-3677-5p/CXCL12 Axis.

Background: Acute monocytic leukemia belongs to type M5 of acute myeloid leukemia (AML) classified by FAB, which appears a high incidence of extramedullary infiltration (EMI) and poor prognosis. In this study, we observed the inhibitory effect of ginsenoside Rk3 on the EMI of monocytic leukemia cells and initially explored its related mechanism of targeting the miR-3677-5p/CXCL12 axis.

Methods: The MTT assay and colony formation assay were used to detect the inhibitory effect of Rk3 on proliferation.

Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021.

Increasing evidence demonstrated that the ketogenic diet (KD) played a positive effect on cancer treatment. However, no systematic review and bibliometric analysis were conducted in this field. This study aimed to explore the current status, and reveal the potential trends and hotspots to provide a reference for future research.

Signal Recognition Based on APSO-RBF Neural Network to Assist Athlete's Competitive Ability Evaluation.

The advanced analysis and research methods of big data will provide theoretical support for the integration of athletes' talent training. The advanced technological methods of big data will also give full play to the advantages of tapping the potential of talents and actively improve the success rate of grassroots young athletes. This paper proposes an improved Adaptive Particle Swarm Optimization (APSO) algorithm for the optimization of radial basis function (RBF) neural network parameters.

Antitumor and immunomodulatory effects of a water-soluble polysaccharide from Lilii Bulbus in mice.

Lilii Bulbus is a popular folk medicine in the worldwide and has attracted great attention due to its bioactivity against respiratory system diseases (include lung cancers). This study was the first report providing in vivo evidences of antitumor potential of the bioactive polysaccharide from Lilii Bulbus. One major fraction (LBP-1) was obtained by purifying the crude polysaccharides extracted from Lilii Bulbus.