Rapid detection of SARS-CoV-2 spike protein using a magnetic-assisted electrochemical biosensor based on functionalized CoFeO magnetic nanomaterials.

The outbreak of novel coronavirus pneumonia (COVID-19) in 2019 has garnered widespread attention. The virus exhibits high contagiousness, and in certain cases, it can lead to recurrent infections. Therefore, it is imperative to develop portable, sensitive, and accurate sensors to promptly detect infected individuals, control the virus's transmission, and determine suitable treatment strategies.

Nanozyme-Catalyzed Metasurface Plasmon Sensor-Based Portable Ultrasensitive Optical Quantification Platform for Cancer Biomarker Screening.

Developing plasmonic biosensors that are low-cost, portable, and relatively simple to operate remains challenging. Herein, a novel metasurface plasmon-etch immunosensor is described, namely a nanozyme-linked immunosorbent surface plasmon resonance biosensor, for the ultrasensitive and specific detection of cancer biomarkers. Gold-silver composite nano cup array metasurface plasmon resonance chip and artificial nanozyme-labeled antibody are used in two-way sandwich analyte detection.

AuPt nanoalloy with dual functionalities for sensitive detection of HPV16 DNA.

Human papillomavirus type 16 (HPV16), one of the high-risk types, is responsible for 53% of cervical cancers. The development of an early diagnostic approach with high sensitivity, low-cost, point-of-care testing (POCT) for HPV16 is urgent. In our work, a novel dual-functional AuPt nanoalloy-based lateral flow nucleic acid biosensor (AuPt nanoalloy-based LFNAB) was established with excellent sensitivity for detecting HPV16 DNA for the first time.

Correction: Facile preparation of a polypyrrole modified Chinese yam peel-based adsorbent: characterization, performance, and application in removal of Congo red dye.

[This corrects the article DOI: 10.1039/D1RA08280A.].

Facile preparation of a polypyrrole modified Chinese yam peel-based adsorbent: characterization, performance, and application in removal of Congo red dye.

In this study, Chinese yam peel (CYP) was modified with polypyrrole an polymerization method to remove Congo red from aqueous media. The prepared CYP-polypyrrole (CYP-PPy) composite was characterized using FTIR, SEM, TEM, XRD, TG and BET analysis. The performance of CYP-PPy towards the adsorption of Congo red (CR) was explored in batch mode.

Gold nanorods-based lateral flow biosensors for sensitive detection of nucleic acids.

A gold nanorod (AuNR)-based lateral flow nucleic acid biosensor (LFNAB) is reported for visual detection of DNA with a short test time and high sensitivity. AuNRs with an approximate length of 60 nm were utilized as a colored tag to label the detection DNA probe (Det-DNA). The capture DNA probe (Cap-DNA) was immobilized on the test region of LFNAB.

Sensitive detection of microRNA-21 in cancer cells and human serum with Au@Si nanocomposite and lateral flow assay.

We report a highly sensitive approach for detecting microRNA-21 (miR-21) in cancer cells and human serum by using Au@Si nanocomposite labeled lateral flow assay. The Au@Si nanocomposite was prepared by coating numerous 3-5 nm gold nanoparticles (GNP) on a silica nanoparticle (SiNP) with a diameter of 150 nm and used as colored label on the lateral flow assay for signal amplification. TEM results show there are around 1000 GNPs coated on the SiNP surface.

Porous graphene oxide/chitosan beads with honeycomb-biomimetic microchannels as hydrophilic adsorbent for the selective capture of glycopeptides.

A porous hydrophilic affinity bead consisting of graphene oxide and chitosan (pGC) with the honeycomb-biomimetic microchannels has been synthesized and applied as hydrophilic adsorbent for selective capture of glycopeptides. The pGC beads have open-porous structure, honeycomb-like microchannels, large interior voids, and hydrophilic property. Based on the multivalent hydrophilic interactions between glycan moieties on glycopeptides and amino groups and hydroxyl groups on chitosan, the glycopeptides were enriched and separated by pGC beads.

A terbium(III)-functionalized zinc(II)-organic framework for fluorometric determination of phosphate.

A terbium(III)-functionalized zinc(II)-organic framework (Tb-MOF-Zn) is shown to be a viable fluorescent probe for phosphate. The organic ligands 4,4',4″-[((2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene))tris(oxy)]tribenzoic acid (HL) contains multiple carboxyl groups that can react with zinc(II) to yield tubular MOF-Zn. The MOF-Zn was further functionalized with Tb(III) to produce a lanthanide composite of type Tb-MOF-Zn which displays strong fluorescence with excitation/emission maxima at 285/544 nm.

Biosensors for early diagnosis of pancreatic cancer: a review.

Pancreatic cancer is characterized by extremely high mortality and poor prognosis and is projected to be the leading cause of cancer deaths by 2030. Due to the lack of early symptoms and appropriate methods to detect pancreatic carcinoma at an early stage as well as its aggressive progression, the disease is often quite advanced by the time a definite diagnosis is established. The 5-year relative survival rate for all stages is approximately 8%.

Gold-platinum nanoflowers as a label and as an enzyme mimic for use in highly sensitive lateral flow immunoassays: application to detection of rabbit IgG.

The authors describe the preparation of gold-platinum nanoflower (AuPt NFs) and show that they can be simultaneously used as a label and as an enzyme mimic in lateral flow immunoassays (LFIs). The AuPt NFs were prepared by growing Pt nanowires on the surface of gold nanoparticle. The assay involves the capture of target proteins (here: rabbit IgG as a model analyte) by the immobilized capture antibody, and by using AuPt NF-labeled secondary antibody.

Evaluation of heterocycle-modified pentathiophene-based molecular donor materials for solar cells.

Two novel solution-processable acceptor-donor-acceptor (A-D-A)-structured organic small molecules with diketopyrrolopyrrole (DPP) as terminal acceptor units and pentathiophene (PTA) or pyrrole-modified pentathiophene (NPTA) as the central donor unit, namely, DPP2(PTA) and DPP2(NPTA), were designed and synthesized. We examined the effects of changing the central bridging heteroatoms of the five-ring-fused thienoacene core identity from sulfur [DPP2(PTA)] to nitrogen [DPP2(NPTA)] in the small-molecule donor material. Replacement of the bridging atom with a different electronic structure has a visible effect on both the optical and electrical properties: DPP2(NPTA), which contains much more electron-rich pyrrole in the central thienoacene unit, possesses red-shifted absorption and a higher HOMO level relative to DPP2(PTA) with the less electron-rich thiophene in the same position.