I-Promoted Synthesis of N-Heteroaromatic Benzothiazoles and 2,2'-Biquinolines via Deaminative Cyclization of Tertiary Amines.

A straightforward I-promoted Povarov multicomponent reaction strategy for the synthesis of N-heteroaromatic benzothiazoles and 2, 2'-biquinolines was described. This methodology involved a one-pot two-step procedure, tandem iodination/Kornblum oxidation, and [4+2] condensation. This protocol was characterized by broad scope of substrates (49 examples, 31-80 % yields), applicable for large-scale preparation, and downstream derivatization of the products.

Effect of Geometrical Parameters on the Mechanical Performance of Bamboo-Inspired Gradient Hollow-Strut Octet Lattice Structure Fabricated by Additive Manufacturing.

Hollow-strut metal lattice structures are currently attracting extensive attention due to their excellent mechanical performance. Inspired by the node structure of bamboo, this study aimed to investigate the mechanical performance of the gradient hollow-strut octet lattice structure fabricated by laser powder bed fusion (LPBF). The effect of geometrical parameters on the yield strength, Young's modulus and energy absorption of the designed octet unit cells were studied and optimized by FEA analysis.

The J evolution model and control technology of the main roadway surrounding rock under superimposed influence of double-coal seam mining.

Under double-seam mining, the main roadway surrounding rock is affected by the superposition of the advanced stress of the two-seam coal working faces. The stress superposition mode and degree are of great significance to the width calculation of the protective coal pillar and the determination of the critical control direction of the surrounding rock. This paper uses theoretical analysis, numerical simulation, and site engineering practice to carry out targeted research.

Enhanced High-Temperature Wear Performance of H13 Steel through TiC Incorporation by Laser Metal Deposition.

High-temperature wear failure has been a major challenge to die parts. This work provides a comprehensive study on the high-temperature wear performance of a TiC/H13 composite coating prepared by laser metal deposition (LMD). The microstructures of wrought H13 samples, LMD-processed H13 and TiC/H13 samples were systematically investigated.

Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells.

Extracellular matrix proteins play important roles in the development of pulmonary hypertension(pH). However, the role of Cartilage oligomeric matrix protein (COMP) in the development of hypoxia-induced pH is largely unknown. We tested the hypothesis that COMP deficiency induced by hypoxia leads to the phenotype switching of pulmonary arterial smooth muscle cells (PASMCs).

[The influence of rhAng-1 on endothelial junctions of BBB after focal cerebral ischemia/reperfusion in rats].

Objective: This study was performed to determine whether recombinant human angiopoietin-1 (rhAng-1) decreases the permeability of the blood-brain barrier (BBB) in focal cerebral ischemia and reperfusion rats, whether RhAng-1 opens the BBB by affecting tight junction associated proteins zonnula occludin-1 (ZO-1), occludin and adherens junction protein vascular endothelial (VE)-cadherin.

Methods: The rats were divided into eight groups randomly( n = 10): (1) sham-operated group; (2) ischemia group; (3)-(5) ischemia/reperfusion (middle cerebral artery occlusion and reperfusion (MCAO/R) 12 h, 48 h, and 7 days) and 0.9% saline groups; (6)-(8) ischemia/reperfusion (MCAO/R 12 h, 48 h, and 7 days) and rhAng-1 groups.