Electronic band structure modulation for sonodynamic therapy.

Sonodynamic therapy (SDT) is a burgeoning and newfangled therapy modality with great application potential. Sonosensitizers are essential factors used to ensure the effectiveness of SDT. For the past few years, a lot of scientists have discovered many valid ways to refine and improve the performance of SDT.

Biomimetic Iron-Based Nanoparticles Remodel Immunosuppressive Tumor Microenvironment for Metabolic Immunotherapy.

Introduction: Immunotherapy has led to a paradigm shift in reinvigorating treatment of cancer. Nevertheless, tumor associated macrophages (TAMs) experience functional polarization on account of the generation of suppressive metabolites, contributing to impaired antitumor immune responses.

Methods: Hence, metabolic reprogramming of tumor microenvironment (TME) can synergistically improve the efficacy of anti-tumor immunotherapy.

Nanozymes in Alzheimer's disease diagnostics and therapy.

Alzheimer's disease (AD) is a progressive neurodegenerative condition that has become an important public health problem of global concern, and the early diagnosis and etiological treatment of AD are currently the focus of research. In the course of clinical treatment, approved clinical drugs mainly serve to slow down the disease process by relieving patients' clinical symptoms. However, these drugs do not target the cause of the disease, and the lack of specificity of these drugs has led to undesirable side effects in treatment.

Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy.

Background: The activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has attracted great attention for its ability to up-regulate innate immune response and thus enhance cancer immunotherapy. However, many STING agonists limit the further advancement of immunotherapy due to weak tumor responsiveness or low activation efficiency. The responsive and effective activation of cGAS-STING signaling in tumors is a highly challenging process.

Synthesis of a Macroporous Conjugated Polymer Framework: Iron Doping for Highly Stable, Highly Efficient Lithium-Sulfur Batteries.

Porous conjugated polymers offer enormous potential for energy storage because of the combined features of pores and extended π-conjugated structures. However, the drawbacks such as low pore volumes and insolubilities of micro- and mesoporous conjugated polymers restrict the loading of electroactive materials and thus energy storage performance. Herein, we report the synthesis of iron-doped macroporous conjugated polymers for hosting sulfur as the cathode of high-performance lithium-sulfur (Li-S) batteries.

Directed Self-Assembly of High χ Poly(styrene--(lactic acid--glycolic acid)) Block Copolymers on Chemical Patterns via Thermal Annealing.

We demonstrated the synthesis and directed self-assembly (DSA) of poly(styrene--(lactic acid--glycolic acid)) (PS--PLGA). Lamellae-forming PS--PLGAs with a range of molecular weights were synthesized by ring-opening polymerization (ROP) of LGA (d,l-3-methyl-1,4-dioxane-2,5-dione) from hydroxy-terminated polystyrene (PS-OH) with stannous octoate as the catalyst and characterized by H NMR spectroscopy, GPC, DSC, TGA, SAXS, and rheometry. The order-disorder transition temperatures () of four PS--PLGA block copolymers were determined by temperature sweep measurements and verified by variable-temperature SAXS, which were used to determine the temperature dependence of χ.