Publications by authors named "Qingan Fu"

Background: With the increasing prevalence of prediabetes and diabetes, exploring dietary factors associated with prediabetes and diabetes has become a global health research priority. This study aimed to assess the relationship between dietary decanoic acid (DDA) intake and the risk of diabetes and prediabetes.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 included 11,477 adult participants.

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Wogonin, an O-methylated flavonoid extracted from Scutellaria baicalensis, has demonstrated profound neuroprotective effects in a range of central nervous system (CNS) diseases. This review elucidates the pharmacological mechanisms underlying the protective effects of wogonin in CNS diseases, including ischemic stroke, hemorrhagic stroke, traumatic brain injury, epilepsy, anxiety, neurodegenerative diseases, and CNS infections. Wogonin modulates key signaling pathways, such as the MAPK, NF-κB, and ROS pathways, contributing to its anti-inflammatory, antioxidant, and antiapoptotic properties.

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Study Objectives: Lipoprotein (a) [Lp(a)] is a biomarker of atherosclerotic cardiovascular disease, but its role in mental disorders is controversial. Our study aimed to explore the causality between Lp(a) levels and mental disorders by combining retrospective and Mendelian randomization (MR) studies.

Methods: All genome-wide association study datasets used in the MR study were obtained from UK Biobank, FinnGen, and the Psychiatric Genomics Consortium.

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Article Synopsis
  • Mitochondrial DNA (mtDNA) is linked to autoimmune diseases (AD), and this study used Mendelian randomization to investigate its causal relationship with 13 specific ADs, including rheumatoid arthritis and lupus.
  • A two-sample analysis was conducted, comparing mtDNA data from the UK Biobank with AD data from the FinnGen Biobank, using various statistical methods to ensure accuracy.
  • Results showed significant associations between mtDNA copy number and several ADs, suggesting mtDNA could be important for future therapeutic strategies in treating these diseases.
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Background: Cardiovascular disease (CVD) remains a leading cause of mortality globally. Environmental pollutants, specifically volatile organic compounds (VOCs), have been identified as significant risk factors. This study aims to develop a machine learning (ML) model to predict CVD risk based on VOC exposure and demographic data using SHapley Additive exPlanations (SHAP) for interpretability.

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  • Lewy body dementia (LBD) is linked to the buildup of misfolded proteins and may be influenced by lipid metabolism disorders, prompting a study that explored the connection between various serum lipids and LBD using a statistical approach called Mendelian randomization.
  • The research revealed that higher levels of low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) are associated with increased risk for LBD, particularly in individuals with the APOE4 gene.
  • Conversely, certain phosphatidylcholine types exhibited protective effects against LBD, suggesting that lipid profiles can influence the disease's development and progression.
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  • Nonalcoholic fatty liver disease (NAFLD) is closely tied to type 2 diabetes, making it important to identify lipid factors that predict abnormal glucose levels in these patients.
  • A study of 1,066 NAFLD patients found that elevated triglycerides (TG) and specific nontraditional lipid measures like the atherogenic index of plasma (AIP) and residual cholesterol (RC) are strongly linked to an increased risk of type 2 diabetes and prediabetes.
  • The findings suggest that incorporating these nontraditional lipid parameters into clinical practice could improve early detection and prevention strategies for diabetes in patients with NAFLD, especially among younger, non-obese, and female individuals.
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Background: Triglyceride-glucose (TyG) index is linked to a poor prognosis for cardiovascular condition and is a valid indicator of insulin resistance. This study evaluated the potential predicting usefulness of the TyG index for all-cause mortality, both short- and long-term, for those concerning critical coronary artery disease (CAD).

Methods: In this study, information from 5452 critically-ill individuals with CAD in intensive care units were gathered from the Medical Information Marketplace in Intensive Care (MIMIC-IV) database.

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Background: Blood counts and biochemical markers are among the most common tests performed in hospitals and most readily accepted by patients, and are widely regarded as reliable biomarkers in the literature. The aim of this study was to assess the causal relationship between blood counts, biochemical indicators and pulmonary arterial hypertension (PAH).

Methods: A two-sample Mendelian randomization (MR) analysis was performed to assess the causal relationship between blood counts and biochemical indicators with PAH.

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Article Synopsis
  • - The study investigates the relationship between lipoprotein(a) [Lp(a)] levels and the risk of ischaemic stroke (IS) in patients with atrial fibrillation (AF), aiming to uncover potential risk factors for IS.
  • - A total of 2,258 participants were analyzed, revealing that IS patients had higher median Lp(a) levels compared to controls, with a significant positive correlation identified between elevated Lp(a) levels and increased IS risk.
  • - The findings suggest that high Lp(a) levels may serve as a relevant risk factor for the onset of IS in AF patients, with significant results persisting across various subgroups like age, sex, and other health conditions.
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Transcatheter aortic valve replacement (TAVR) has increasingly become a safe, feasible, and widely accepted alternative surgical treatment for patients with severe symptomatic aortic stenosis. However, the incidence of conduction abnormalities associated with TAVR, including left bundle branch block (LBBB) and high-degree atrioventricular block (HAVB), remains high and is often correlated with risk factors such as the severity of valvular calcification, preexisting conditions in patients, and procedural factors. The existing research results on the impact of post-TAVR conduction abnormalities and permanent pacemaker (PPM) requirements on prognosis, including all-cause mortality and rehospitalization, remain contradictory, with varied management strategies for post-TAVR conduction system diseases across different institutions.

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Gallstone disease (GSD) is thought to be associated with the risk of coronary heart disease (CHD) or acute myocardial infarction (AMI), which may be due to abnormal cholesterol metabolism. We used multiple Mendelian randomization (MR) methods based on publicly available genome-wide association study data to assess whether this association is genetically causal and to search for loci driving causality. Pooled data for GSD were obtained from FinnGen Biobank and Biobank Japan, while CHD and AMI were obtained as pooled data from the CARDIoGRAMplusC4D consortium.

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Familial hypercholesterolemia (FH) is a common hereditary cholesterol metabolic disease that usually leads to an increase in the level of low-density lipoprotein cholesterol in plasma and an increase in the risk of cardiovascular disease. The lack of disease screening and diagnosis often results in FH patients being unable to receive early intervention and treatment, which may mean early occurrence of cardiovascular disease. Thus, more requirements for FH identification and management have been proposed.

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Background And Aims: Familial hypercholesterolemia (FH) is becoming a global burden. However, it remains underdiagnosed and undertreated worldwide. This study aimed to observe the screening rate of FH patients and department distribution among hospitalized patients using different diagnostic criteria.

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(1) Background: Existing lipid-lowering therapies have difficulty in achieving lipid target levels in patients with familial hypercholesterolemia (FH), especially in the treatment of patients with homozygous familial hypercholesterolemia. (2) Method: All of the literature data containing "Familial hypercholesterolemia" and "Gene Therapy" in PubMed and Clinical Trials from 2018 to 2022 were selected. (3) Results: The rapid development of gene therapy technology in recent years is expected to change the treatment status of FH patients.

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Background: Lipoprotein (a) [Lp(a)] is a proven independent risk factor for coronary heart disease. It is also associated with type 2 diabetes mellitus (T2DM). However, the correlation between Lp(a) and T2DM has not been clearly elucidated.

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