Interhemispheric Asymmetry in the High-Latitude Neutral Density Variations During the 13-14 March 2022 Storm.

During the second recovery phase of the 13-14 March 2022 storm, intense high-latitude neutral mass density spikes are detected by satellites at ∼500 km in both hemispheres. These density spikes, accurately modeled by the Global Ionospheric Thermosphere Model (GITM), are identified as high-latitude neutral mass density anomalies (HDAs). The GITM simulation indicates that these HDAs, which extends over the polar region, are important features in high-latitude neutral density.

D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils.

Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of the components of the periodontium. It significantly impacts oral health and has been linked to systemic conditions like cardiovascular disease and diabetes. The critical role of neutrophils in the occurrence and development of chronic periodontitis has been paid increasing attention.

Pan-ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytes.

White matter (WM) abnormalities are an emerging feature of schizophrenia, yet the underlying pathophysiological mechanisms are largely unknown. Disruption of ErbB signaling, which is essential for peripheral myelination, has been genetically associated with schizophrenia and WM lesions in schizophrenic patients. However, the roles of ErbB signaling in oligodendrocytes remain elusive.

Fibrin aggravates periodontitis through inducing NETs formation from mitochondrial DNA.

Objectives: This study investigated the role of fibrin on neutrophil extracellular traps (NETs) formation from neutrophils and to elucidate the involvement of mitochondria in NETs formation during periodontitis.

Materials And Methods: Plasminogen-deficient (Plg) mice were employed to evaluate the effects of fibrin deposition on inflammation, bone resorption, and neutrophil infiltration in periodontal tissues. In addition, in vitro tests evaluated fibrin's impact on neutrophil-driven inflammation.

AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.

The roles and mechanisms of A-kinase anchoring protein 1 (AKAP1) in vascular smooth muscle cell (VSMC) phenotypic modulation and neointima formation are currently unknown. AKAP1 is a mitochondrial PKA-anchored protein and maintains mitochondrial homeostasis. This study aimed to investigate how AKAP1/PKA signaling plays a protective role in inhibiting VSMC phenotypic transformation and neointima formation by regulating mitochondrial fission.

Melatonin Inhibits Testosterone Synthesis in Rooster Leydig Cells by Targeting CXCL14 through miR-7481-3p.

Melatonin has been proved to be involved in testosterone synthesis, but whether melatonin participates in testosterone synthesis by regulating miRNA in Leydig cells is still unclear. The purpose of this study is to clarify the mechanism of melatonin on Leydig cells testosterone synthesis from the perspective of miRNA. Our results showed that melatonin could significantly inhibit testosterone synthesis in rooster Leydig cells.

RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.

Background And Aims: The pathological roles and mechanisms of Rho-specific guanine nucleotide dissociation inhibitor 3 (RhoGDI3) in vascular smooth muscle cell (VSMC) phenotypic modulation and neointima formation are currently unknown. This study aimed to investigate how RhoGDI3 regulates the Nod-like receptor protein 3 (NLRP3) inflammasome in platelet-derived growth factor-BB (PDGF-BB)-induced neointima formation.

Methods: For in vitro assays, human aortic VSMCs (HA-VSMCs) were transfected with pcDNA3.

Disruption of peritrophic matrix chitin metabolism and gut immune by chlorantraniliprole results in pathogenic bacterial infection in Bombyx mori.

Chlorantraniliprole (CAP) is widely used in pest control, and its environmental residues affect the disease resistance of non-target insect silkworms. Studies have demonstrated that changes in gut microbial communities of insects are associated with susceptibility to pathogens. In the present study, we examined the effects of CAP exposure on the immune system and gut microbial community structure of silkworms.

Effects of artificial diet breeding on intestinal microbial populations at the young stage of silkworm (Bombyx mori).

The silkworm (Bombyx mori) is an economically important insect and serves as a model organism for Lepidoptera. To investigate the effects of the intestinal microbial population on the growth and development of larvae fed an artificial diet (AD) during the young stages, we analyzed the characteristics of the intestinal microbial population using 16S rRNA gene sequencing technology. Our results revealed that the intestinal flora of the AD group tended to be simple by the 3rd-instar, which Lactobacillus accounting for 14.

Angiotensin II Inhibits Adipogenic Differentiation and Promotes Mature Adipocyte Browning through the Corepressor CtBP1.

The mechanisms of angiotensin II (Ang II) on regulating adipogenic differentiation and function remain unknown. In this study, we focus on revealing the role of C-terminal-binding protein 1 (CtBP1) on Ang II-mediated adipogenic differentiation and mature adipocyte browning. Amounts of 3T3-L1 and CtBP1-KO 3T3-L1 were treated with Ang II for 24 h and then induced adipogenic differentiation, or cells were first induced differentiation and then treated with Ang II.

The effects of glyphosate exposure on gene transcription and immune function of the silkworm, Bombyx mori.

Glyphosate is a widely used herbicide and crop desiccant. However, whether its extensive use has any effect on the species diversity of nontarget organisms is still unclear. In this study, we used the silkworm, Bombyx mori, as the research subject, and performed RNA sequencing to analyze the transcriptional profile of silkworm midgut after exposure to glyphosate at 2975.

Parameter Sensitivity Analysis of Mounting Pedestals and Multi-Objective Optimization for a Multi-Support Rigid Body System.

In this paper, a parameter sensitivity analysis of mounting pedestals and a multi-objective optimization design for vibration reduction in a multi-support rigid body system, taking an aeroengine-lubricating oil tank supported by multiple mounting pedestals as an example, are conducted based on the third version of non-dominated sorting genetic algorithm (NSGA-Ⅲ) combined with Sobol's sensitivity analysis method (SSAM). An aeroengine-lubricating oil tank with three mounting pedestals is simplified as a three-support dynamic system, and its dynamics model is established. Several structural parameters of mounting pedestals are taken as the design variables, and the system vibration response and the reaction force of the front and rear mounting pedestals are considered as the objective functions.

Sublethal chlorantraniliprole exposure induces autophagy and apoptosis through disrupting calcium homeostasis in the silkworm Bombyx mori.

The intensive application of chlorantraniliprole (CAP) leaves residues in the environment, posing a potential threat to non-target organisms. In the present study, we investigated the adverse effects of sublethal CAP exposure on Bombyx mori. Sublethal CAP (0.

Melatonin inhibits testosterone synthesis in Roosters Leydig cells by regulating lipolysis of lipid droplets.

Leydig cells are important component of testis cells, which can synthesize testosterone with free cholesterol derived from lipid droplets (LDs). It is well known that melatonin could regulate synthesis of testosterone. However, it is still unclear whether melatonin participates in the synthesis of testosterone by regulating the lipolysis of LDs in Leydig cells.

Effect of Tachinid Parasitoid on the Larval Development and Pupation of the Host Silkworm .

The Tachinidae are natural enemies of many lepidopteran and coleopteran pests of crops, forests, and fruits. However, host-tachinid parasitoid interactions have been largely unexplored. In this study, we investigated the effects of tachinids on host biological traits, using , a generalist parasitoid, and the silkworm , its lepidopteran host, as models.

Untargeted LC-MS-based metabonomic analysis of the effect of photoperiod on the testes of broiler roosters.

Photoperiod is an important factor that stimulates the reproductive performance of broiler breeder roosters. However, the mechanism by which photoperiod affects the reproductive performance of broiler breeder roosters has not been fully studied. To study the effects of different photoperiods on the reproductive performance of broiler breeder roosters, 120 Arbor Acres broiler breeder roosters aged 20 weeks were randomly assigned to three groups (n = 40), and the three groups were treated with different photoperiod regimes: control (CTR; 12.

Imbalance of intestinal microbial homeostasis caused by acetamiprid is detrimental to resistance to pathogenic bacteria in Bombyx mori.

The neonicotinoid insecticide acetamiprid is widely applied for pest control in agriculture production, and its exposure often results in adverse effects on a non-target insect, Bombyx mori. However, only few studies have investigated the effects of exposure to sublethal doses of neonicotinoid insecticides on gut microbiota and susceptibility to pathogenic bacteria. In this study, we aimed to explore the possible mechanisms underlying the acetamiprid-induced compositional changes in gut microbiota of silkworm and reduced host resistance against detrimental microbes.

Melatonin inhibits the apoptosis of rooster Leydig cells by suppressing oxidative stress via AKT-Nrf2 pathway activation.

Oxidative stress has been described as a key driver of Leydig cell apoptosis. Melatonin has antioxidative and antiapoptotic effects, but the potential effects and mechanism of melatonin on oxidative stress and apoptosis in rooster Leydig cells remain unclear. Our results showed that melatonin biosynthetic enzymes and melatonin receptors were expressed in rooster Leydig cells and their expression were locally inhibited as rooster sexual maturation.

Optimization design of a novel X-type six-high rolling mill based on maximum roll system stiffness.

The present investigation devices a novel X-type six-high (X-6h) mill. In addition, parametric models of different roll layouts such as the four-high (4-h), I-type six-high (I-6h), and X-6h mills are established. Three-dimensional (3D) finite element (FE) contact analysis for a strip rolling process is conducted when the mills are subjected to a constant vertical load of 65 kN.

Correction: Maxwell-Stefan diffusion coefficient estimation for ternary systems: an ideal ternary alcohol system.

Correction for 'Maxwell-Stefan diffusion coefficient estimation for ternary systems: an ideal ternary alcohol system' by Tariq Allie-Ebrahim et al., Phys. Chem.