Fluorescent probes for sensing and visualizing methylglyoxal: progress, challenges, and perspectives.

Methylglyoxal (MGO) plays an important role not only in physiological processes but also in pathological conditions, including diabetes, hypertension, and Alzheimer's disease. Therefore, developing accurate quantitative tools for MGO is of great significance for studying pathogenesis. Among the various methods available, the fluorescent probe method has garnered considerable attention due to its noninvasive detection capability, exceptional optical properties, good biocompatibility, and high sensitivity.

Application of biochar and selenium together at low dose efficiently reduces mercury and methylmercury accumulation in rice grains.

Irrespective of cost and ecological risk, literatures have reported that both biochar and selenium (Se) alone at high application rate exhibited positive effects on decreasing rice mercury (Hg) uptake in high Hg contaminated paddy soil. In this study, we investigated whether biochar and Se together at low dose could efficiently reduce the rice grain Hg and MeHg accumulation in the slight Hg-contaminated soil. Compared with control (CK), the Hg concentration of grains in the BC3, Se0.

Aptasensors application for cow's milk allergens detection and early warning: Progress, challenge, and perspective.

Cow's milk allergy (CMA) is considered one of the most prevalent food allergies and a public health concern. Modern medical research shows that the effective way to prevent allergic reactions is to prevent allergic patients from consuming allergenic substances. Therefore, the development of rapid and accurate detection technology for milk allergens detection and early warning is critical to safeguarding those with a cow milk allergy.

Potential role of endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity-an update.

As a chemotherapy agent, doxorubicin is used to combat cancer. However, cardiotoxicity has limited its use. The existing strategies fail to eliminate doxorubicin-induced cardiotoxicity, and an in-depth exploration of its pathogenesis is in urgent need to address the issue.

Non-linear association of triglyceride-glucose index with cardiovascular and all-cause mortality in T2DM patients with diabetic kidney disease: NHANES 2001-2018 retrospective cohort study.

Background: The triglyceride glucose (TyG) index is a cutting-edge and highly effective marker of insulin resistance, a crucial factor in the development and exacerbation of diabetic kidney disease (DKD). To date, there has been limited research on how the triglyceride-glucose (TyG) index affects the outlook for patients suffering from DKD.

Methods: In this multicenter retrospective cohort study, the analysis recruited 2,203 DKD patients from the National Health and Nutrition Examination Survey (NHANES) dataset, which covers the US from 2001 to 2018.

Separating the effects of life course adiposity on diabetic nephropathy: a comprehensive multivariable Mendelian randomization study.

Aims: Previous Mendelian randomization (MR) of obesity and diabetic nephropathy (DN) risk used small sample sizes or focused on a single adiposity metric. We explored the independent causal connection between obesity-related factors and DN risk using the most extensive GWAS summary data available, considering the distribution of adiposity across childhood and adulthood.

Methods: To evaluate the overall effect of each obesity-related exposure on DN (Ncase = 3,676, Ncontrol = 283,456), a two-sample univariate MR (UVMR) analysis was performed.

MG53: A new protagonist in the precise treatment of cardiomyopathies.

Cardiomyopathies (CMs) are highly heterogeneous progressive heart diseases characterised by structural and functional abnormalities of the heart, whose intricate pathogenesis has resulted in a lack of effective treatment options. Mitsugumin 53 (MG53), also known as Tripartite motif protein 72 (TRIM72), is a tripartite motif family protein from the immuno-proteomic library expressed primarily in the heart and skeletal muscle. Recent studies have identified MG53 as a potential cardioprotective protein that may play a crucial role in CMs.

Novel insights into transfer RNA-derived small RNA (tsRNA) in cardio-metabolic diseases.

Cardio-metabolic diseases, including a cluster of metabolic disorders and their secondary affections on cardiovascular physiology, are gradually brought to the forefront by researchers due to their high prevalence and mortality, as well as an unidentified pathogenesis. tRNA-derived small RNAs (tsRNAs), cleaved by several specific enzymes and once considered as some "metabolic junks" in the past, have been proved to possess numerous functions in human bodies. More interestingly, such a potential also seems to influence the progression of cardio-metabolic diseases to some extent.

Development, Physicochemical Properties, and Antibacterial Activity of Propolis Microcapsules.

Propolis is a well-known natural antibacterial substance with various biological activities, such as anti-inflammatory and antioxidant activity. However, applications of propolis are limited due to its low water solubility. In this study, propolis microcapsules were developed with a core material of ethanol extract of propolis and shell materials of gum arabic and β-cyclodextrin using a spray-drying technique.

Antioxidant and antibacterial activity of honey against serovar Typhimurium.

serovar Typhimurium ( Typhimurium) is a common food-borne pathogen that commonly causes gastroenteritis in humans and animals. honey (ALH) harvested in China has significant antibacterial activity against , and . We hypothesize that ALH has antibacterial activity against Typhimurium.

Analysis of Evaluation Dimensions of Public Service Motivation of Chinese College Students-Qualitative Study Based on Grounded Theory.

Public service motivation (PSM) represents an individual's predisposition to respond to motives grounded primarily or uniquely in public institutions, and it is an individual characteristic that reflects the attributes of the public sector. The concept was first introduced by James Perry, who identified four-dimensions to measure PSM, namely, attraction to policy making, commitment to the public interest, compassion, and self-sacrifice. Public service motivation changes over time, and differences in culture and systems in different countries can lead to differences in the measurement dimensions of PSM.

Preliminary study on 24p3 / neutrophil gelatinase-associated lipocalin (NGAL) ferroptosis inhibition in renal tubular epithelial cells.

The 24p3/neutrophil gelatinase-associated lipocalin (NGAL) protein plays an important protective role in acute kidney injury (AKI), but the exact mechanism remains unclear. Therefore, we have made a preliminary exploration of its mechanism. The experimental group was formed by constructing and transfecting 24P3 overexpressed plasmid into renal tubular epithelial cells.

Simultaneous reduction in cadmium and arsenic accumulation in rice (Oryza sativa L.) by iron/iron-manganese modified sepiolite.

It is challenging to reduce the cadmium (Cd) and arsenic (As) contents of brown rice simultaneously due to their converse chemical behaviors in the paddy soil. Clay minerals, such as sepiolite (SEP), have significant advantages in remediating Cd-contaminated soil. Moreover, iron or manganese oxide loaded SEP can improve the As adsorption efficiency.