Phenolic compounds from sappan lignum and their anti-neuroinflammatory activities.

Caesappanols A-F (1-6), six undescribed phenolic compounds, including two dibenzofurans (1, 2), three biphenols (3-5), and one homoisoflavan (6), along with ten known compounds (7-16), were isolated from Sappan Lignum, the heartwood of Caesalpinia sappan L. Compounds 1 and 2 represent the initial discovery of dibenzofuran skeletons within this herb. Structural elucidation of these compounds was achieved through comprehensive analysis of 1D NMR, 2D NMR, and mass spectrometry data.

(+)/(-)-Corydecumbenpines A and B, two pairs of dimeric phthalide-benzophenanthridine alkaloids with cytotoxicity from Corydalis decumbens.

Four pairs of previously undescribed enantiomers, including two pairs of dimeric phthalide-benzophenanthridine alkaloid and two pairs phthalides derivatives, corydecumbenpines A-D, were isolated from the rhizomes of Corydalis decumbens. Their planar structures were elucidated by extensive spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR. Optically pure compounds were obtained by chiral chromatography and their absolute configurations were determined by single-crystal X-ray crystallography and comparison of experimental and calculated ECD spectra.

Residing in areas with high residential greenspace is associated with increased COPD risk and decreased lung function of adults in eastern China.

Background: Evidence for a relation between residential greenspace and respiratory health is scarce and controversial.

Objectives: The purpose of this study was to explore the association between residential greenspace and its interaction with particulate matter (PM) and risk of chronic obstructive pulmonary disease (COPD) and lung function.

Methods: A total of 3,759 adults were recruited from Wenzhou in this study.

Key Structure Parameters for Designing High-Performance Substrates of Surface-Enhanced Infrared Absorption Spectroelectrochemistry.

Attenuated total reflectance surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) plays a crucial role in understanding the interfacial reaction mechanisms at the molecular level, achieving an enhancement factor (EF) of up to 10. However, when this technique is integrated with electrochemistry (EC-ATR-SEIRAS), the EF is significantly reduced by ten- to hundred-fold. Thus, understanding of the key parameters that contribute to the EF is of great importance in designing high-performance substrates and extending the application for EC-SEIRAS.

Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition worldwide, demanding further investigation into its pathogenesis. Circular RNAs (circRNAs) are emerging as pivotal regulators in MASLD processes, yet their pathological implications in MASLD remain poorly understood. This study focused on elucidating the role of circular RNA ribonucleotide reductase subunit M2 (circRRM2) in MASLD progression.

Cevanine-type steroidal alkaloids from the bulbs of Fritillaria cirrhosa D. Don.

Eight previously undescribed cevanine-type steroidal alkaloids, cirrhosinones I-N and cirrhosinols A-B, along with five known analogs, were isolated from the bulbs of Fritillaria cirrhosa D. Don. Their structures were elucidated on the basis of comprehensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and single-crystal X-ray diffraction analyses.

Triterpenoids from the hook-bearing stems of .

An unprescribed nortriterpenoid with an aromatic E ring, uncanortriterpenoid A (), together with fourteen known triterpenoids (-), were isolated from the hook-bearing stems of Miq. Based on extensive spectroscopic analyses, the NMR data of , and in CDOD were assigned for the first time, and the wrongly assigned of C-27 and C-29 of were revised. Among the known compounds, , and were isolated from this species for the first time, and represents the first lanostane triterpenoid bearing an extra methylidene at C-24 for the Rubiaceae family.

Ultrasensitive Plasmon-Enhanced Infrared Spectroelectrochemistry.

IR spectroelectrochemistry (EC-IR) is a cutting-edge operando method for exploring electrochemical reaction mechanisms. However, detection of interfacial molecules is challenged by the limited sensitivity of existing EC-IR platforms due to the lack of high-enhancement substrates. Here, we propose an innovative plasmon-enhanced infrared spectroelectrochemistry (EC-PEIRS) platform to overcome this sensitivity limitation.

Steroidal alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their anti-inflammatory activities.

Fourteen previously undescribed steroidal alkaloids, including six jervine-type, wabujervine A-E and wabujerside A, seven cevanine-type, wabucevanine A-G, and one secolanidin-type, wabusesolanine A, along with thirteen known steroidal alkaloids, were isolated from the bulbs of Fritillaria unibracteata var. wabuensis. On the basis of comprehensive analysis of IR, HRESIMS, 1D and 2D NMR spectroscopic data, and single-crystal X-ray diffraction analyses, their structures were elucidated.

Discovery of steroidal alkaloid glycosides from the bulbs of Fritillaria unibracteata with anti-inflammatory activities using an in vivo zebrafish model.

Nine undescribed steroidal alkaloid glycosides, unibrasolanosides A-F, unibraverazosides A-B, and unibratomatoside A, were isolated from the bulbs of Fritillaria unibracteata P. K. Hsiao & K.

[Steroids from Uncaria rhynchophylla].

Thirteen steroids(1-13) were isolated from the non-alkaloid constituents of Uncaria rhynchophylla by column chromatography on silica gel, ODS, Sephadex LH-20, and preparative HPLC chromatography, and their structures were elucidated by analyses of the MS and NMR spectral data. All the compounds were isolated from the genus Uncaria for the first time, and 1 was a new compound. The ~1H-NMR and ~(13)C-NMR data of two compounds(12 and 13) in deuteron-chloroform were completely assigned.

[Quality standard of Lobeliae Chinensis Herba].

In light of related methods in Chinese Pharmacopoeia(2020 edition), this study established the quality standard for Lobeliae Chinensis Herba. The TLC identification method was established with silica gel GF_(254) thin layer plate, diosmin standard, linarin standard, and the reference material of Lobeliae Chinensis Herba. The loss on drying, total ash, acid-insoluble ash, and ethanol-soluble extracts of 18 batches of Lobeliae Chinensis Herba samples were determined according to the general principles in Chinese Pharmacopoeia.

Condensation derivatives of 4-isopropylbenzaldehyde with acetophenone from the red alga Laurencia tristicha.

Seven undescribed condensation derivatives of 4-isopropylbenzaldehyde with acetophenone, including one 1,3,5-trisubstituted pentane-1,5-dione, two 1,3,4,5,7-pentasubstituted heptane-1,7-diones and four 1,2,3,4,5-pentasubstituted cyclohexanols, together with two known flavonoids, were obtained from the red alga Laurencia tristicha. The relative configurations were elucidated by extensive spectroscopic data analysis of MS, 1D and 2D NMR, while the absolute configurations were determined by comparing the experimental and calculated electronic circular dichroism spectra. All the isolates were proven to be naturally occurring in the red alga by LC-MS analysis, and these 1,3,5-trisubstituted-pentane-1,5-dione, 1,3,4,5,7-pentasubstituted-heptane-1,7-diones and 1,2,3,4,5-pentasubstituted-cyclohexanols were reported from natural sources for the first time.

[Research on in vivo metabolites of Longxue Tongluo Capsules by liquid chromatography coupled with hybrid ion trap/time-of-flight mass spectrometry].

Longxue Tongluo Capsules(LTC) has good efficacy against blood stasis syndrome during the recovery period of ischemic stroke. Its main active ingredient is the phenolic extract of Chinese dragon's blood. In our previous study, the primary mass fragmentation pathways of phenolic derivatives from LTC were clarified.

Sesquiterpenoids from .

One new cis -coumaroyl copaborneol-type sesquiterpenoid (), together with its known trans isomer () and six other known -coumaroyl humulane-type sesquiterpenoids (), were isolated from the whole plants of . Their structures were determined by spectroscopic data. Compounds exhibited moderate antimycobacterial activity against HRv.

[Research advances of Zaoren Anshen prescription preparations].

Zaoren Anshen prescription preparations(ZRASs), which are prepared from three traditional Chinese herb medicines, namely fried Zizyphi Spinosae Semen, Salvia Miltiorrhizae Radix et Rhizoma and vinegar-processed Schisandrae Chinensis Fructus, are a series of proprietary Chinese medicines for the treatment of insomnia, amnesia and dizzy in clinic. In recent years, pharmacodynamic effect, chemical constituents and quality control of ZRASs had been extensively studied for the purpose of ensuring their safety, efficacy and stability, and a great progress had been made. However, there is no review of the research advance of ZRASs up to date.

Discovery of novel potential plant growth regulators from Corydalis mucronifera.

Three pairs of enantiomers mucroniferals A-C (1-3), with a novel skeleton of 1,4-epoxynaphthalene-2,3-dicarboxylic acid first reported from nature source, were isolated from Corydalis mucronifera. Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR, and their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of the experimental and calculated ECD data. Mucroniferals A-C showed broad-spectrum inhibitory activities on seedling growth of all plants tested (Lepidium apetalum, Raphanus sativus, Lactuca sativa, and Arabidopsis thaliana) with a dose-dependent relationship.

Three new -coumaroylated sesquiterpenoids from .

Four -coumaroylated sesquiterpenoids (), including three new ones (, , and ), were isolated from the whole plants of . Their structures were established on the basis of comprehensive spectroscopic analysis and comparison with data reported in the literature. Compounds were evaluated for their antimycobacterial activities, and and were active against HRv with the MIC values of 19.

The effectiveness of cupping therapy on chronic fatigue syndrome: A single-blind randomized controlled trial.

Background: and purpose: We investigated the effectiveness of cupping therapy with three different pressures in patients with chronic fatigue syndrome (CFS).

Materials And Methods: The participants were randomly assigned to three groups, as follows: cupping pressure of -0.02 mpa (n = 38), -0.

Anthropometry did not approach adequate predictive accuracies for detecting elevated fasting plasma glucose or hemoglobin A1c levels among Chinese children aged 7-9 years.

Aims/introduction: Elevated concentrations of fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c) are well-established independent risk factors for progression to diabetes, cardiovascular comorbidities and mortality. Most previous studies on the relationships of anthropometric measures with hyperglycemia were carried out among adults and adolescents, but few data are available for the performance predication of the predictors for diagnosing elevated FPG or HbA1c among young children.

Materials And Methods: Involving 5,556 students of aged 7-9 years, a school-based cross-sectional survey was carried out between March and June 2019 in Shenzhen, China.

Antioxidant terpenoids from the red alga .

One new laurane-type sesquiterpene, 10-hydroxyepiaplysinol (), along with two known related sesquiterpenes, epiaplysinol () and bisabol-9-en-7,11-diol (), and one carotenoid metabolite, loliolide (), were obtained from the red alga . Their structures were elucidated based on comprehensive spectroscopic data analysis. Of the known compounds, was isolated from the genus for the first time.

Estimation of salt intake assessed by 24-h urinary sodium level among adults speaking different dialects from the Chaoshan region of southern China.

Objective: Dietary salt intake may vary depending on different lifestyles. We aimed to estimate the different salt intakes and evaluate the knowledge and self-awareness about salt among people speaking the Teochew, Teochew-Hakka and Hakka dialects in the Chaoshan region of southern China.

Design: The study followed a cluster sampling of residents in Chaoshan region.

Anti-inflammatory quinoline alkaloids from the root bark of Dictamnus dasycarpus.

Six undescribed quinoline alkaloids, named dasycarines A-E, and 18 known ones were isolated from the root bark of Dictamnus dasycarpus. All the structures were elucidated on the basis of comprehensive analysis of UV, IR, NMR, and HRMS spectroscopic data, and the absolute configurations were assigned via comparison of the calculated and experimental ECD data. (+)-Dasycarine A (1a) and (-)-Dasycarine A (1b) are a pair of enantiomers of dimeric furoquinoline alkaloid, which are the first dimeric via [2 + 2] cycloaddition of furan.

Three new compounds from and their anti-inflammatory activities.

Three new compounds (-), named dasycarine G (), dasycarether (), and dasycarester (), along with seven known compounds (-) obtained from the genus for the first time, were isolated from the root bark of . Their structures were elucidated on the basis of spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, and CD). In the assay, compounds , , , , and exhibited NO inhibitory effects of LPS-induced BV-2 cells with IC values in the range of 10.