Clinical application of mixed reality holographic imaging technology in scaling and root planing of severe periodontitis: a proof of concept.

Objectives: To demonstrate the potential application of mixed reality (MR) holographic imaging technology in subgingival scaling and root planing (SRP) for patient with advanced periodontitis.

Methods: This case series comprised the analysis of 1566 sites from 261 teeth of 10 patients with advanced periodontitis. Digital CBCT scans and intraoral scans of the patients were digitally acquired preoperatively and aligned to create a three-dimensional periodontal visualization model.

Hyperresponsiveness of human gingival fibroblasts from patients with aggressive periodontitis against bacterial lipopolysaccharide.

The present study aimed to investigate whether gingival fibroblasts (GFs) of patients with aggressive periodontitis (AgP) are more sensitive to lipopolysaccharide (LPS) stimulation than GFs of control subjects. AgP causes rapid periodontal destruction, including the production of cytokines [i.e.

Biomarkers in Metabolic Syndrome Patients with Chronic Periodontitis.

Objectives: To investigate whether the levels of serum C-reactive protein (CRP), salivary interleukin (IL)-6 and IL-lβ in metabolic syndrome (MS) patients can be potential monitors for inflammation in MS patients with severe periodontitis.

Methods: A total of 114 MS patients and 49 systemically healthy subjects were enrolled. CRP in serum and IL-1β and IL-6 in non-stimulated whole saliva were collected from these patients and subjects and analysed by enzyme-linked immunosorbent assay (ELISA).

Porphyromonas gingivalis Infection Accelerates Atherosclerosis Mediated by Oxidative Stress and Inflammatory Responses in ApoE-/- Mice.

Background: The periodontal pathogen Porphyromonas gingivalis (P. gingivalis) has been proven to accelerate the development of atherosclerosis in apolipoprotein E (ApoE)-deficient mice. In this study, we used an ApoE knockout (ApoE-/-) mouse model with chronic intravenous infection with P.

Salivary extracellular RNA biomarkers for insulin resistance detection in hispanics.

Aims: Insulin resistance (IR) detection is challenging and no test is currently used in clinical practice. We developed salivary biomarkers that could be used for IR detection.

Methods: We collected saliva from 186 healthy and 276 pre-diabetic participants, divided them into high and low IR groups based on a HOMA cutoff of 2.

Tanshinone IIA Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice Infected with Porphyromonas gingivalis.

Tanshinone IIA (TSA), a pharmacologically active component isolated from Danshen, may prevent cardiovascular diseases due to its anti-inflammatory, anti-oxidative, and anti-adipogenic effects. Porphyromonas gingivalis, a major periodontal pathogen, may contribute to the progression of atherosclerosis. Here, we studied the effects of TSA on atherosclerosis in ApoE mice with P.

Mitochondrial reactive oxygen species mediate the lipopolysaccharide-induced pro-inflammatory response in human gingival fibroblasts.

Although periodontal diseases are initiated by bacteria that colonize the tooth surface and gingival sulcus, the host response is believed to play an essential role in the breakdown of connective tissue and bone. Mitochondrial reactive oxygen species (mtROS) have been proposed to regulate the activation of the inflammatory response by the innate immune system. However, the role of mtROS in modulating the response of human gingival fibroblasts (HGFs) to immune stimulation by lipopolysaccharides (LPS) has yet to be fully elucidated.

[Effects of Er, Cr: YSGG laser on the root surface of periodontitis and healthy teeth].

Objective: To evaluate the effects of Er, Cr: YSGG laser on the root surface of periodontally involved teeth and healthy teeth, concerning the microstructure and the roughness.

Methods: Eight freshly extracted teeth due to severe periodontitis and eight freshly extracted teeth due to orthodontic reasons or being third molar were chosen in this study. The root surface of each tooth was divided into four areas, and received four treatment

Methods: no treatment (control group); root planing with Gracey scaler for 30 seconds; irradiation by the lower power Er, Cr: YSGG laser; irradiation by the higher power Er, Cr: YSGG laser.

[Chronic periodontitis with Takayasu arteritis: a case report].

This case report concerns a 23-year-old woman with chronic periodontitis who had been previously diagnosed with Takayasu arteritis (TA). Her erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were decreased before and 3 months after non-surgical periodontal therapy with no change in her prescribed medications (ESR from 31.00 mm/h to 23.

Green tea epigallocatechin-3-gallate alleviates Porphyromonas gingivalis-induced periodontitis in mice.

Porphyromonas gingivalis causes inflammation, and leads to the periodontitis in gingival tissue damage and bone resorption. Epigallocatechin-3-gallate (EGCG) is a major polyphenol extract from green tea with plenty of pharmacological functions. The aim of this study was to determine whether continuous oral intake of EGCG would alleviate P.

[Association between chronic periodontitis and metabolic syndrome related mitochondria single nucleotide polymorphism].

Objective: To investigate the relationship between Mitochondrial DNA(mtDNA) SNP and the severity of periodontitis.

Methods: In the study, 227 subjects in a community of Beijing received questionnaire interview, periodontal examination and biochemical laboratory examination in 2005. The designed primer was used to amplify the specific mtDNA fragments with PCR, and sequence the PCR products.

[Periodontal status of patients with post-acute myocardial infarction].

Objective: To evaluate the periodontal status of post-acute myocardial infarction patients, to identify whether periodontitis is associated with post-acute myocardial infarction in Chinese community population.

Methods: Case and control subjects were enrolled from a community population, the diagnose of post-acute myocardial infarction and systemic health were based on blood, electrocardiogram and ultrasound examinations by physicians. Full mouth periodontal examinations were performed in 103 post-acute myocardial infarction patients and 52 healthy subjects.

[Correlation between periodontitis and metabolic syndrome of the middle-aged and aged population in Shijingshan community of Beijing].

Objective: To survey the metabolic status of the middle-aged and aged population with periodontitis in Shijingshan community of Beijing, and investigate the relationship between periodontitis and metabolic syndrome (MS).

Methods: The middle-aged and aged population in the community were investigated by questionnaires, periodontal clinical examinations and blood biochemical tests in 2005. A total of 903 subjects were enrolled, who were divided into two groups by severity of periodontitis.

[Effects of bio-glass in subgingival scaling and root planing].

Objective: To evaluate the effect of locally applied bio-glass on the teeth hypersentivity and periodontal recovery after subgingival scaling and root planing.

Methods: In this double blind study, 60 patients with chronic periodontitis were included and were randomly divided into four groups of 15 patients: bio-glass powder and bio-glass paste group (Po+Pa), bio-glass powder group (Po), bio-glass paste group (Pa) and control group. Powder was applied in pockets after subgingival scaling and root planning (SRP) and paste was used as toothpaste for 6 weeks.

[Effect of supportive periodontal therapy in maintaining the long-term effect of the initial therapy].

Objective: To evaluate the influence of supportive periodontal therapy to the long-term effect after initial therapy.

Methods: The investigation was conducted as a retrospective longitudinal study over a period of at least 2 years, a total of 39 patients recruited in the study and divided into non-maintenance group (n=22) and maintenance group (n=17). Non-maintenance group were monitored for an average of 5.

[Levels of tumor necrosis factor-alpha and interleukin-1beta in saliva of metabolic syndrome patients].

Objective: To investigate the association between periodontitis and the low-grade inflammation in metabolic syndrome (MS) patients.

Methods: Fifty-seven MS patients, 26 healthy controls were enrolled. Non-stimulated whole saliva was collected.

Relationship of metabolic syndrome to chronic periodontitis.

Background: Many studies have suggested that periodontal disease is related to metabolic disorders. Few studies have investigated metabolic syndrome (MS), as defined by the International Diabetes Federation in 2005, in the Chinese population. The aim of this study was to assess the association of periodontitis with MS.

[Analysis of dental plaque by using cellular neural network-based image segmentation].

Objective: To establish and evaluate a new method for measurement of dental plaque by using cellular neural network-based image segmentation.

Methods: A total of 195 subjects were selected from community population. After dental plaque staining, oral digital picture of anterior teeth area was taken by an Olympus digital camera (C-7070 Wide Zoom).

[Analysis of risk indicator for nifedipine-induced gingival hyperplasia].

Objective: To investigate the prevalence and risk indicator of nifedipine-induced gingival overgrowth in a community population in Beijing.

Methods: A cross-sectional survey was conducted in 616 community subjects with hypertension or coronary vascular disease in Beijing, China. Among them 205 individuals took nifedipine for at least half year and 411 individuals who had never received calcium channel blocker (CCB) were recruited as controls.

[Computerized image processing in esthetic rehabilitation of anterior teeth].

Objective: To investigate the application of computerized image processing in esthetic rehabilitation of anterior teeth.

Methods: Thirteen patients with esthetic problems in anterior teeth were included in this study. Oral digital images were obtained before and during treatment with a digital camera.

[Effect of verapamil on the proliferation of normal gingival fibroblast].

Objective: To evaluate the effect of verapamil on the proliferation of normal gingival fibroblast (NGF) in vitro.

Methods: NGF was isolated and cultured. The 5th passage of NGF was incubated with 0, 0.