The acute pulmonary toxicity in mice induced by multiwall carbon nanotubes, benzene, and their combination.

Carbon nanotubes (CNTs) have been synthesized and produced on large scale for their wide application. They have high absorption ability to organic contaminants (such as benzene) and can form CNTs-benzene combination with benzene. In this article, the acute pulmonary toxicity, induced by multiwall carbon nanotubes (MWCNTs), benzene, and their combination, was studied by administrating the three test materials into mice lungs via intratracheal instillation.

Pulmonary responses to polyhydroxylated fullerenols, C(60)(OH)(x).

Although many scientists have been attracted by polyhydroxylated fullerenols for their radical-scavenging and antioxidant ability in vivo and in vitro and their potential use as a drug or for drug delivery, there is little information on their pulmonary toxicological properties. The aim of this study was to investigate the effect of polyhydroxylated derivatives of fullerene on Sprague-Dawley rats after intratracheal instillation. Polyhydroxylated fullerenols [C(60)(OH)(x), x = 22, 24] were administered intratracheally (1, 5 or 10 mg per rat).

[Selective adsorption of multi-walled carbon nanotubes with liquiritin and isoliquiritin].

Selective adsorption of active ingredients liquiritin and isoliquiritin from Glycyrrhiza uralensis Fisch with multi-walled carbon nanotubes (MWNTs) has been studied. Distribution coefficients of liquiritin between ethanol solvent and r-MWNTs or o-MWNTs in 293K is 37.5 and 43.

[Fluorescence properties of C60-glucocorticoids].

C60 and its derivatives have become a research hotspot because of their unique structures, physical and chemical properties. The fluorescence properties of C60 and its derivatives are an important research embranchment of the fullerene science field. In the present paper the fluorescence properties of C60-glucocorticoids were firstly investigated.

Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation.

The pathological lesions induced by multiwalled carbon nanotubes (MWCNTs) in bronchi and alveoli of mice were studied by intratracheal instillation and inhalation. In instillation groups, the dose was 0.05 mg MWCNTs/mouse.

Reactions of fullerenes with reactive methylene organophosphorus reagents: efficient synthesis of organophosphorus group substituted C60 and C70 derivatives.

Treatment of C70 with cycloalkylaminomethylenebisphosphonates in the presence of NaH gave corresponding C70 dimers 1 in good yield, while the methanofullerenes, C70>CH(PO3Et2) (3) and C70>C(PO3Et2)2 (4) or C60>CH(PO3Et2) (5) and C60>C(PO3Et2)2 (6), were obtained, respectively, by the reaction of C70 or C60 with tetraethyl methylenediphosphonate in the presence of NaH. Diethyl cyanomethylphosphonate reacted with C60 or C70 under similar conditions to afford C60>C(PO3Et2)CN (7) and C70>C(PO3Et2)CN (8). Furthermore, the presence of weak electronic interactions between two fullerene cages of fullerene dimers was demonstrated by cyclic voltammetry.