[Surgical treatment of ruptured anterior circulation aneurysms in elders].

Objective: To explore some related problems in surgical treatment of ruptured anterior circulation intracranial aneurysms in elders.

Methods: The clinical data of 38 elderly patients with ruptured anterior circulation intracranial aneurysms were analyzed retrospectively.Such related problems as indication, timing and complications of operation were discussed through their Modified Rankin scales at discharge and half a year later.

[Intraoperative decisions and surgical efficacies of trigeminal neuralgia responsible vessels].

Objective: To explore the types of primary trigeminal neuralgia (TN) responsible vessels and curative efficacies of microscopic vascular decompression (MVD).

Methods: A total of 162 primary TN patients underwent MVD from August 2004 to the present at our hospital.Their clinical data were collected and analyzed.

[Correlation of surgical timing and prognosis for ruptured intracranial aneurysms].

Objective: To explore the correlation between surgical timing and clinical prognosis for ruptured intracranial aneurysms.

Methods: A series of 187 patients with intracranial aneurysm treated surgically at our department were analyzed retrospectively. Among them, 101 patients received an average follow-up period of 9 months (range: 6 - 14).

[Clinical experiences of normal saline pressed injection via lumbar puncture in the treatment of apnea due to acute tonsillar hernia].

Objective: To summarize the clinical experiences of normal saline pressed injection via lumbar puncture in the treatment of acute tonsillar hernia induced apnea. This procedure was routinely carried out after external ventricular drainage and/or lesion removal via open craniotomy.

Methods: During the period of 1969 to 2005, a total of 43 patients failed to regain respiratory after external ventricular drainage using rapid small hole cranio-puncture apparatus or lesion removal via open craniotomy.

Optimization of transfection efficiency of small interfering RNA in purified human prolactinoma cells.

Background: Control of hypersecretion of certain hormones is one of the key targets in the treatment of pituitary adenomas. RNA interference has been shown to inhibit protein expression, and thus it may represent a promising method for the treatment of pituitary adenomas. In the present study, transfection efficiency of small interfering RNA (siRNA) was optimized in human prolactinoma cells.

[Study on prognostic factors of chronic severe hepatitis].

Objective: To analyze factors influencing prognosis and to develop a prognosis predicting model for patients with chronic severe hepatitis.

Methods: Clinical data from 408 patients suffering from chronic severe hepatitis were divided into improved group and deteriorated group. The main clinical and laboratory variables were analyzed as predictive factors of prognosis with logistic regression analysis.